DNA Repair: Tumor Development and Therapeutic Response

In association with the AACR Radiation Science and Medicine Working Group

November 2-5, 2016
Hyatt Regency Montreal
Montreal, Quebec, Canada

Conference Co-chairpersons
Robert G. Bristow, University Health Network Princess Margaret Hospital, Toronto, ON, Canada
Maria Jasin, Memorial Sloan Kettering Cancer Center, New York, New York
Theodore S. Lawrence, University of Michigan, Ann Arbor, Michigan

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  • Watch this message from conference co-chairpersons Robert G. Bristow and Theodore S. Lawrence:


An effective DNA damage response is needed as a “guardian of the genome” to maintain its stability and prevent unchecked cellular growth or tumor development. Based on large consortia-based sequencing efforts, deficiencies in DNA repair are often seen in different cancers across multiple pathways. This has implications not only for tumor development, but also tumor response to treatment, as defects may also be exploited to make tumors hypersensitive to radiation therapy, chemotherapy, or molecular targeted agents.   

This AACR Special Conference will discuss the inherent DNA repair deficiencies in cancer and opportunities for novel therapies that target: defects in DNA damage checkpoint signaling, defects in homologous recombination and replication stress, mutations in DNA repair genes, and DNA repair defects secondary to the tumor microenvironment. Eight plenary sessions will be presented, and short proffered talks from early-career scientists will be integrated into each session.

“DNA Repair: Tumor Development and Therapeutic Response” is designed to be of interest to cancer scientists and physicians whose expertise spans from basic to clinical research. This conference will take a critical look at the basic research underpinnings that inform clinical therapeutics and will discuss how observations from clinical practice can be back-translated into basic mechanistic research.

Continuing Medical Education Activity AMA PRA Category 1 CreditsTM available