Michael B. Sporn, MD
Professor of Pharmacology and Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire
Dr. Sporn's principal research efforts over his entire career have been devoted to prevention of cancer. He has been a pioneer in the field of chemoprevention. His major contributions have included: the exposition and validation of the autocrine hypothesis of the genesis and progression of tumors; the discovery, purification, and elucidation of the biology of the transforming growth factor-beta family; and the provision of both a conceptual and experimental framework for understanding the antineoplastic actions of retinoids, rexinoids, and synthetic triterpenoids.
The fields profoundly influenced by Dr. Sporn's contributions include not only cancer biology, but also immunology, inflammation, oxidative stress, wound healing, and embryonic development. Current research in his laboratory is devoted to chemoprevention of lung, breast, and pancreatic cancer, using animal models of very aggressive disease. The goal of these studies is to develop new and safe drugs for prevention of clinical disease in people at especially high risk; chemoprevention using combinations of drugs is receiving special attention.
2012-present Project Director, National Foundation for Cancer Research2005 Brinker Award, Susan G. Komen Breast Cancer Foundation2004 National Cancer Institute Eminent Scholar2002 AACR-Cancer Research Foundation of America Award for Excellence in Cancer Prevention Research1998 Bristol-Myers Squibb Award for Distinguished Achievement in Cancer Research1998 Elected Fellow, American Association for the Advancement of Science1995-2005 Editor-in-Chief, Cytokine and Growth Factor Reviews1994 Medal of Honor, American Cancer Society1994 Mider Lecture Award, National Institutes of Health1993-1995 Board of Directors, AACR1991 AACR-Bruce F. Cain Memorial Award1982 Lila Gruber Award for Cancer Research, American Academy of Dermatology1978-1995 Chief, Laboratory of Chemoprevention, National Cancer Institute1973-1978 Chief, Lung Cancer Branch, National Cancer Institute1959 MD, University of Rochester