In This Section

Jeffrey M. Rosen, PhD, Honored With 2022 William L. McGuire Memorial Lecture Award

SAN ANTONIO – Jeffrey M. Rosen, PhD, will receive the William L. McGuire Memorial Lecture Award at the 2022 San Antonio Breast Cancer Symposium (SABCS), to be held December 6-10, 2022.

The William L. McGuire Memorial Lecture Award was established in 1992 to commemorate McGuire’s significant contributions to breast oncology. McGuire, along with Charles A. Coltman, MD, founded SABCS in 1977.

Rosen is a distinguished service professor of molecular and cellular biology and the coleader of the breast cancer program at the Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine.  A pioneer in the fields of mammary gland biology and endocrinology, Rosen is being recognized for his extraordinary contributions to preclinical and translational breast cancer research, and for his commitment to transdisciplinary collaboration and mentoring of early-career scientists.

Throughout his 53-year career in cancer research, Rosen has made numerous groundbreaking contributions, including understanding hormonal regulation of mammary gland development, tumorigenesis, and milk production; developing widely used animal models to study normal development and tumorigenesis of the breast; elucidating the mechanisms underlying self-renewal and differentiation of mammary stem cells and cancer stem cells; clarifying the roles of epithelial-to-mesenchymal transition in breast cancer metastasis and therapeutic resistance; and characterizing the tumor immune microenvironment associated with different subtypes of breast tumors.

Rosen joined the faculty at Baylor College of Medicine in 1973 and was a founding member of the Department of Cell Biology, the first department of its kind in the United States. While on sabbatical in the laboratory of George Stark, PhD, Rosen was involved in the early studies that elucidated the mechanisms of interferon action, which helped lead to the discovery of the JAK/STAT pathway. In addition to his scientific research, Rosen has mentored more than 100 graduate students, postdoctoral fellows, and junior faculty members.

“I am humbled to receive the McGuire Award,” said Rosen. “I first met Bill McGuire over 50 years ago at a Hormone Action Gordon Research Conference, and I was fortunate to have many scientific interactions with him during his lifetime. Bill provided both the inspiration and encouragement for my career in breast cancer research. I hope that the development and utilization of breast cancer preclinical models will be important in personalizing and modifying treatment options, particularly in terms of combining therapies and employing immunotherapy in the treatment of metastatic breast cancer.”

Rosen has been recognized with various honors and awards, including election as a Fellow of the American Academy of Arts and Sciences in 2015. He received the American Association for Cancer Research Distinguished Lectureship in Breast Cancer Research in 2017, the Susan G. Komen Brinker Basic Science Award in 2010, the Michael E. DeBakey, MD, Excellence in Research Award in 2004, and the Barbara & Corbin J. Robertson Jr. Presidential Award for Excellence in Education in 2002, among many others.

“Dr. Rosen’s contributions to breast cancer discovery and translational research have been an example to many of us in this field. He is an outstanding recipient of the McGuire Award,” said Carlos L. Arteaga, MD, FAACR, director of the Simmons Comprehensive Cancer Center and associate dean of Oncology at UT Southwestern Medical Center. Arteaga is the codirector of SABCS and chair of the McGuire Award selection committee.

Rosen will present a lecture titled “Leveraging Preclinical Models for Translational Breast Cancer Research” during the Symposium.

Download a photo of Dr. Rosen