Executive Vice President;
Global Head
Oncology Disease Area
Novartis Biomedical Research
Cambridge, MA
For invaluable contributions to the chemical biology of kinase signaling, including elucidating the complex dynamic effects of small-molecule inhibitors on the RAS->RAF->MEK pathway and their implications for cancer therapy. Dr. Malek is renowned for discoveries in RAF inhibitor-induced paradoxical activation, the kinase-independent role of BRAF in MAPK signaling, and the mechanisms of resistance to next-generation RAF inhibitors. Her innovative work has not only deepened the mechanistic understanding of oncogenic kinase networks but has also directly influenced the design of novel therapeutic strategies that continue to shape the future of targeted cancer treatment.
The AACR Award for Outstanding Achievement in Chemistry in Cancer Research was established in 2007 to recognize outstanding, novel, and significant chemistry research, which has led to important contributions in basic cancer research; translational cancer research; cancer diagnosis; the prevention of cancer; or the treatment of patients with cancer. To learn more please visit the press release.
View Past Recipients.