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Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant

Grant Amount $7,000,000 USD
Grant Term3 Years
Start of Grant Term07/01/2017
Letter of Intent Deadline12/01/2016 12:00 PM (EST)
Letter of Intent Notification DateJanuary 9, 2017
Application Deadline12/01/2016 12:00 PM (EST)
Decision Date3/31/2017 12:00:00 AM
Description

The Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant represents a new, focused effort to implement advances in colorectal cancer research as rapidly as possible through the creation of a collaborative, translational, cancer research "Dream Team." The most talented and promising researchers across institutions will be assembled into a Dream Team, forming an optimal configuration of expertise needed to solve key problems in colorectal cancer and positively impact patients in the near future. This Dream Team will span multiple disciplines and utilize the new tools of modern biology to attack research questions in a coordinated way. Mechanisms to foster collaborations within and among the Dream Teams will be employed - an approach that promotes the sharing of information and a goal-oriented focus on measurable milestones of progress. SU2C believes that this unique Dream Team model will advance scientific research in the interests of both today's cancer patients and those who may develop cancer in the future.

The grant will provide up to $7 million in funding over a 3-year grant term, depending upon project requirements, and will be contingent on the SU2C Scientific Advisory Committee (SAC) finding that the funds are justified and that milestones and objectives have been appropriately selected and are being satisfactorily pursued and achieved.

Research Project Criteria

This grant is for a translational cancer research project that addresses critical problems in colorectal cancer treatment and patient care. The project must include therapeutic interventions for colorectal cancer and deliver near-term patient benefit through investigation by a multidisciplinary, multi-institutional, synergistic Dream Team of expert investigators. The project must be designed to accelerate the application of therapeutic agents to the clinic (i.e., lead to patient involvement within 2-3 years from the beginning of the grant). Proposals for Dream Team research projects must present plans indicating how the work will be translated into the clinic. The ideas should be based on perceived opportunities for success as well as high-priority areas with a critical need for rapid progress beyond current medical care.

Eligibility Criteria

To maximize creativity, innovation, and collaboration, the Dream Team must include laboratory and clinical researchers, senior and/or young investigators, and senior scientists who have not worked together in the past.

Each Team will consist of a Dream Team Leader, a Dream Team Co-leader, no more than four additional Dream Team Principals, and at least two Advocates.

The Dream Team Leader, Co-leader and Principals, collectively referred to as Key Personnel, must have acquired a doctoral or medical degree, and must be independent investigators affiliated with an academic, medical, or research institution. There are no citizenship or residency status restrictions.

The Dream Team Leader and Co-leader are expected to each dedicate at least 20 percent (or 40 percent combined) of their time and effort to the Dream Team research project. Dream Team Principals must each dedicate at least 10 percent of their time and effort to the Dream Team research project.

No Dream Team will have more than one Key Personnel (Dream Team Leader, Co-leader, or Principal) from any given institution at the time of their initial appointment on the Team. No more than two Key Personnel may be from affiliated institutions. It is expected that additional Investigators from the Dream Team Leader's, Co-leader's or Principals' institutions may be involved in the Dream Team research project in some other capacity, and there is no limit to the number of Investigators from each of these institutions that may contribute to the Dream Team project.

Employees or subcontractors of for-profit industry are not eligible to serve as a Dream Team Leader, Co-leader, or Principal, however their participation as Collaborators is encouraged, where appropriate, to foster the development of novel diagnostic and treatment strategies. No grant funds may be directed to Collaborators working within a U.S. government institution/agency or a for-profit industry. Confidentiality and intellectual property issues must be negotiated with Collaborators prior to their participation in a Dream Team research project.

Young Investigators, including junior faculty, postdoctoral fellows, clinical research fellows, or any other researchers working under the direction of a scientific mentor, are not eligible to serve as a Dream Team Leader, Co-leader, or Principal, however their participation in the Dream Team research projects is encouraged.

There are no citizenship or residency status restrictions. Neither members of the SU2C SAC nor members of their individual laboratories are eligible for funding as part of the Stand Up To Cancer Colorectal Cancer Dream Team Translational Research Grant. Key Personnel should not be funded on more than one SU2C-sponsored Dream Team grant. Except for the Dream Team Leader and Co-leader, scientists may be funded concurrently on SU2C and SU2C Canada grants. No more than 50 percent of the Principals (including Leader and Co-leader) from a previous Dream Team may apply as a group on a new Dream Team proposal.

Citizenship Requirements

There are no citizenship or residency status restrictions.

AACR Membership Requirements

None

Application Instructions

The AACR requires applicants to submit an electronic application via proposalCENTRAL by 12:00 pm (noon), Eastern Time on Tuesday, December 1, 2016, using the proposalCENTRAL website at https://proposalcentral.altum.com.

The Program Guidelines and Application Instructions are available in PDF format.

The Call For Ideas document is available available here.