Class of 2021
Scientific Areas of Expertise: Anti-Cancer Therapies; Genetic Models of Cancer; p53 Tumor Suppressor Pathway
For establishing that p53 contains a transactivation domain, in turn defining the protein as a transcription factor; for showing the potent effects of Mdm2 and Mdm4 in p53 inhibition; for dissecting p53-mediated cell cycle arrest and senescence activities as tumor suppressive mechanisms; for exploring its physiologic significance in potential anticancer therapies; and for showing gain-of-function properties of missense p53 mutants resulting in the functional inactivation of p63 and p73.