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AACR-Johnson & Johnson Lung Cancer Innovation Science Grants | Grant Status - Open

Grant Amount$ 1,500,000 USD

Grant Term

3 Year(s)

Start of Grant Term

7/1/2018

Application Deadline

5/2/2018 1:00:00 PM

Application Deadline Time Zone

Eastern Standard Time

Decision Date

6/2018

Additional Information

April 2, 2019 – Grant recipients must attend the Grants Reception and Dinner (April 2) to formally accept their grant. Grant funds may be used to support the grantees’ registration and attendance at this Annual Meeting.

Annual Site Visits may also be conducted. The Progress Review Committee, consisting of AACR staff and external reviewers, will visit the team at the Lead PI institution or co-PI institutions as needed. Beginning in year two of the grant, recipients will also be invited to present their work at an annual symposium. The Project Teams as well as AACR and Johnson & Johnson will be invited to attend. 

Program Guidelines and Application Instructions are available in PDF format.

Description

Because of the late onset of clinical symptoms and inadequate screening programs, nearly two-thirds of all lung cancers are diagnosed at an advanced stage and, as a result, five-year survival rates are still below 18%. Interventions at the earliest stages of the disease process while there are no clinical manifestations, or when the tumor is small and localized, improves survival outcomes; therefore, simple yet accurate diagnostic tools that can improve the detection of early lung cancers are urgently needed.

The AACR-Johnson & Johnson Lung Cancer Innovation Science Grants represent a joint effort to address this need by promoting and supporting pioneering cancer research. Proposals should focus on understanding the behaviors that lead to chronic exposures to respiratory carcinogens and how these behaviors can be modified; how chronic exposures produce cellular/genomic damage and how these can be ameliorated; deciphering the types of inflammation that underlie the carcinogenic process; understanding the alterations in innate and adaptive immunity that create an immune-permissive microenvironment; and changes in the pulmonary microbiome that may contribute to carcinogenesis. Proposals that characterize premalignant lesions or that substantially improve the detection of lung cancer at more curable stages will also be prioritized.

This project must be implemented by a multi-institutional team, composed of Principal Investigators from at least two, but no more than three, different institutions. The Grant will provide $1.5 million in funding for direct and indirect expenses related to each research project over a three year timeframe.

In addition to the grant, the AACR will provide strategic project management support to help optimize project implementation and progress during the grant term.

Research Project Criteria

​Proposals will be accepted for new ideas and innovative approaches that have direct application and relevance to lung cancer early detection. Proposed research projects can be in any discipline including basic, translational, or clinical cancer research. Proposals should focus on understanding the behaviors that lead to chronic exposures to respiratory carcinogens and how these behaviors can be modified; how chronic exposures produce cellular/genomic damage and how these can be ameliorated; deciphering the types of inflammation that underlie the carcinogenic process; understanding the alterations in innate and adaptive immunity that create an immune-permissive microenvironment; and changes in the pulmonary microbiome that may contribute to carcinogenesis. Proposals that characterize premalignant lesions or that substantially improve the detection of lung cancer at more curable stages will also be prioritized.

Eligibility Criteria

​​At least two, but no more than three, co-applicants serving as co-Principal Investigators (co-PIs) from distinct institutions are required. The team will be directed by the Lead Principal Investigator (Lead PI) who is responsible for the application, disbursement of funds to the various research projects, the conduct of the projects, and progress reporting.

Principal Investigators (PIs) must have a doctoral degree (including PhD, MD, DO, DC, ND, DDS, DVM, ScD, DNS, PharmD, or equivalent doctoral degree) in the biomedical sciences or in a field applicable to health science research and not currently be a candidate for a further doctoral or professional degree.

In addition to the co-PIs, the Project Team should also include at least one young investigator (e.g., postdoctoral or clinical research fellow; junior faculty member). While not a co-PI, this young investigator should play a key role in the project.

Applications will be accepted from independent investigators at all levels who are affiliated with an academic, medical, or research institution anywhere in the world.

Citizenship Requirements

There are no citizenship or geographic requirements; however, by submitting an application for this grant, an applicant applying from an institution located in a country in which they are not a citizen or a permanent resident assures that the visa status will provide sufficient time to complete the project and grant term at the institution from which they applied.

AACR Membership Requirements

​​AACR membership is required. Nonmembers interested in this grant opportunity must submit a satisfactory application for AACR Active Membership by Wednesday, May 2, 2018. The application will be applied to 2018 membership dues. Applications may be submitted using the Official Application for Membership online or downloaded as a PDF and submitted to the AACR office with the required documents.

Application Instructions

​AACR requires applicants to submit an electronic application by 1:00pm, U.S. Eastern Time on Wednesday, May 2, 2018, using the proposalCENTRAL website at https://proposalcentral.altum.com.