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FINDING CURES TOGETHER<sup>SM</sup>

The Function of Tumor Microenvironment in Cancer Progression

​January 7-10, 2016
Hard Rock Hotel
San Diego, California

Conference Co-Chairpersons
Raghu Kalluri, The University of Texas MD Anderson Cancer Center, Houston, Texas
Robert A. Weinberg, MIT Whitehead Institute for Biomedical Research, Cambridge, Massachusetts
Douglas Hanahan, Swiss Institute for Experimental Cancer Research (ISREC), Lausanne, Switzerland
Morag Park, Goodman Cancer Research Centre, McGill University, Montréal, Quebec, Canada

Tumors are composite of many different cellular and non-cellular constituents that surround the malignant cancer cells harboring activating mutations in oncogenes or loss of tumor suppressors that drive tumor growth. The functional contribution of TME constituents such as leukocytes, fibroblasts, endothelial cells (both blood and lymphatic), and other stromal components is evolving. It has been appreciated for some time that TME plays a significant role in disease progression, but the precise function of each constituent remains unknown. A variety of infiltrating immune cells, cancer-associated fibroblasts, and angiogenic endothelial cells play expanding and critical functions in sustaining cell proliferation, evading growth suppressors, promoting survival, activating invasion and metastasis, and reprogramming energy metabolism. Some constituents of the TME are also involved in restraining tumor growth and metastasis. This AACR Special Conference will focus on discussing the emerging concepts in stromal cell and ECM heterogeneity, stromal cell metabolism, early events in carcinogenesis involving contributions from tumor cells and their microenvironment, stress responses to oxygen and nutrient gradients, translational impact of targeting the microenvironment, tumor immunity and immunotherapy. We will also discuss therapeutic opportunities revealed by these innovative and interdisciplinary discoveries.

Continuing Medical Education Activity AMA PRA Category 1 CreditsTM available


Supporter:

​Bristol-Myers Squibb


Professional Education Grants:

​Celgene​Gilead
​Lilly ​Novartis


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