Please note that this meeting will take place as an in-person event in San Diego and will not live-stream content for virtual participation. The meeting content will be recorded and made available as an on-demand program after the conference. Please see the Registration page for details. 

CME credit is available for in-person attendance for the designated sessions. On-demand presentations are not eligible for CME.

All presentations are scheduled to be live, in-person presentations at the date and time specified below unless noted otherwise.  Program in progress.

[U]- On-Demand Recording Unavailable

Thursday, November 17

Welcome and Keynote Lecture
Plenary Session 1: DNA Repair

Friday, November 18

Plenary Session 2: Inflammation and Aging
Plenary Session 3: Effect of Racial Injustice and Stress on Cancer
Plenary Session 4: Somatic Mutations and the Aging Process
Keynote Lecture

Saturday, November 19

Plenary Session 5: Aging in the Tumor Microenvironment
Plenary Session 6: Epigenetics and Aging
Plenary Session 7: Senescence and Aging

Sunday, November 20

Plenary Session 8: Cancer, Aging, and Metabolism
Closing Keynote

Thursday, november 17

Welcome and Keynote Lectures
5:30-6:45 p.m.

Welcome & Introduction
Joanna L. Groden, University of Illinois, Chicago, Illinois

Opening Keynote
DNA damage repair: Impact on aging and cancer and applications of nutritional interventions
J.H.J (Jan) Hoeijmakers, Erasmus Medical Center, Rotterdam, The Netherlands

Plenary Session 1: DNA Repair
Session Chair: Joanna L. Groden, University of Illinois, Chicago, Illinois
6:45-7:45 P.M.

Inherited DNA repair defects and premature aging 
Alan D. D’Andrea, Dana-Farber Cancer Institute, Boston, Massachusetts 

Neuronal genome stability and plasticity
Andre Nussenzweig, National Cancer Institute, Bethesda, Maryland

Opening Reception
7:45-9 p.m.

friday, November 18

Continental Breakfast
7-8 A.M.

Plenary Session 2: Inflammation and Aging
Session Chair: Ami S. Bhatt, Stanford University, Stanford, California
8-10 A.M.

Defining immunological age in the context of breast cancer progression and therapeutic response 
Sandra S. McAllister, Harvard Medical School, Boston, Massachusetts

Dissecting the role of aging and inflammation on clonal hematopoiesis*
Marco De Dominici, University of Colorado Anschutz Medical Campus, Aurora, Colorado

From hematopoiesis to immunity:  Delineating the impact of aging on B-cell acute lymphoblastic leukemia progression
Curtis J. Henry, Emory University School of Medicine, Atlanta, Georgia

Cytokines surge in the blood years prior to a cancer diagnosis in elderly individuals*
Guangbo Chen, Stanford University, Stanford, California

Measuring the microbiome: Improving the predictive power of microbiome analysis in cancer outcomes
Ami S. Bhatt, Stanford University, Stanford, California

Break
10-10:30 A.M.

Plenary Session 3: Effect of Racial Injustice and Stresss on Cancer
Session Chair: Robert A. Winn, VCU Massey Cancer Center, Richmond, Virginia
10:30 A.M.–12 P.M.

The impact of place on cancer: Socioeconomic status, access and discrimination 
Electra D. Paskett, The Ohio State University, Columbus, Ohio 

Role of race in accelerating progression of colorectal cancer 
John M. Carethers, University of Michigan, Ann Arbor, Michigan 

Structure matters: A call to action
Robert A. Winn, VCU Massey Cancer Center, Richmond, Virginia

Lunch on Own
12-2 P.M.

Plenary Session 4: Somatic Mutations and the Aging process
Session Chair: Joanna L. Groden, University of Illinois, Chicago, Illinois 
2–3:45 p.m.

The DNA damageome and cancer 
Susan Rosenberg, Baylor College of Medicine, Houston, Texas 

Apoptotic DNase DFFB mediates stress-induced mutagenesis*
Matthew J. Hangauer, UC San Diego, La Jolla, California

Older adult-specific microbes correlate with treatment response and markers of T-cell senescence in NSCLC* 
Daniel Spakowicz, The Ohio State University, Columbus, Ohio 

Breast cancer suppressor BRCA2 and separation of function alleles in the mouse [U]
Maria Jasin, Memorial Sloan Kettering Cancer Center, New York, New York

TP53 somatic evolution in healthy fallopian tube across the full spectrum of human lifespan*
Rosana Risques, University of Washington, Seattle, Washington

break
3:45-4 P.M.

Keynote Lecture
Session Chair: Steven E. Artandi, Stanford Cancer Institute, Stanford, California
4-5 P.M.

Mutations in normal cells 
Michael R. Stratton, Wellcome Sanger Institute, Cambridge, England 

Poster Session A/Reception
5-6:30 P.M.

Saturday, november 19

continental breakfast
7-8 A.M.

Plenary Session 5: Aging in the Tumor Microenvironment
Session Chair: Sheila A. Stewart, Washington University in St. Louis, St. Louis, Missouri
8-10:15 A.M.

Age-related changes in the tumor microenvironment drive tumor progression 
Sheila A. Stewart, Washington University in St. Louis, St. Louis, Missouri 

Integrating noise into a signal: Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underly breast cancer susceptibility* 
Mark A. LaBarge, Beckman Research Institute at City of Hope, Duarte, California 

Age-related changes in pancreatic fibroblasts enhance pancreatic cancer growth and invasion 
Daniel J. Zabransky, Johns Hopkins University, Baltimore, Maryland 

Physical and metabolic aspects of therapy induced senescence and polyploidy in an evolving tumor microenvironment* 
Michelle R. Dawson, Brown University, Providence, Rhode Island 

Identification and characterization of the cancer permissive environment in companion dogs* 
Jaime F. Modiano, University of Minnesota, Minneapolis, Minnesota 

The role of aging in reactivation from metastatic melanoma dormancy
Mitchell Fane, Johns Hopkins School of Public Health, Baltimore, Maryland

Break
10:15-10:45 A.M.

Plenary Session 6: Epigenetics and Aging
Session chair: Michelle C. Barton, OHSU Knight Cancer Institute, Portland, Oregon
10:45 A.M.-12:45 P.M.

The tick tock of epigenetic clocks in patients with cancer
Christin E. Burd, The Ohio State University, Columbus, Ohio

Revisiting the bad luck hypothesis: Cancer risk and aging are linked to replication-driven changes to the epigenome*
Morgan E. Levine, Yale School of Medicine, New Haven, Connecticut

Epigenetic mechanisms of tissue aging
Payel Sen, National Institute on Aging, Baltimore, Maryland

Aging-induced reprogramming of the cell of origin defines lung cancer evolution* 
Xueqian Zhuang, Memorial Sloan Kettering Cancer Center, New York, New York 

An oncogenic histone reader promotes metaplastic TNBC
Michelle C. Barton, OHSU Knight Cancer Institute, Portland, Oregon

Lunch on Own
12:45-2:45 P.M.

Plenary Session 7: Senescence and aging
Session Chair: Steven E. Artandi, Stanford Cancer Institute, Stanford, California
2:45-4:15 P.M.

Immune-mediated targeting of senescent cells
Corina Amor, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

TXNRD1 drives innate immune response in senescent cells to promote tumor immune surveillance and age-associated inflammation* 
Xue Hao, The Wistar Institute, Philadelphia, Pennsylvania 

Pre-malignant plasma cells exhibit a senescence-like phenotype and accumulation of transposable elements* 
Gabriel Alvares Borges, Mayo Clinic, Rochester, Minnesota 

Title to be announced
Steven E. Artandi, Stanford Cancer Institute, Stanford, California

Poster Session b/Reception
4:15-6 P.M.

Sunday, November 20

Breakfast
7-8 A.M.

Plenary Session 8: Cancer, Aging, and Metabolism
Session Chair: Eileen P. White, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
8-10 A.M.

Increased mitochondrial DNA mutation burden with age limits lung cancer [U]
Eileen P. White, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey

BH3 profiling of senescent cancer cells to identify mechanisms of resistance to ABT-263* 
Fleur Jochems, The Netherlands Cancer Institute, Amsterdam, The Netherlands 

Studies of aging, morphology, and cancer in the domestic dog
Elaine A. Ostrander, NIH National Human Genome Research Institute, Bethesda, Maryland

Sugar intake and premature aging in adult of childhood cancer in the St. Jude Lifetime (SJLIFE) cohort* 
Tuo Lan, Washington University School of Medicine, St. Louis, Missouri 

Age-induced metabolic reprogramming: A bridge between the aging process and tumorigenesis 
Ana P. Da Silva Gomes, H. Lee Moffitt Cancer Center, Tampa, Florida 

Break
10-10:30 A.M.

Closing keynote
Session Chair: Steven E. Artandi, Stanford Cancer Institute, Stanford, California 
10:30-11:30 A.M.

Age against the machine: How the aging microenvironment drives tumor progression 
Ashani T. Weeraratna, Johns Hopkins University, Baltimore, Maryland 

Closing Remarks
11:30 A.M.

Steven E. Artandi, Stanford Cancer Institute, Stanford, California