In This Section

Program

Please note that this meeting will take place as an in-person event in Montreal, Quebec, Canada and will not live-stream content for virtual participation. The meeting content will be recorded and made available as an on-demand program after the conference. Please see the registration page for details

All presentations are scheduled to be live, in-person presentations at the date and time specified below unless noted otherwise. Program in progress.

*- Short talk selected from proffered abstracts

WEDNESDAY, DECEMBER 10 

THURSDAY, DECEMBER 11 

FRIDAY, DECEMBER 12 

SATURDAY, DECEMBER 13 

Wednesday, December 10

REGISTRATION

4-8 p.m. | Grand Salon Opera Foyer

WELCOME AND OPENING Keynote

6-7:30 p.m. | Grand Salon Opera AB

  • 6 p.m. | Welcome 
    Andrea Cercek, Memorial Sloan Kettering Cancer Center, New York, New York
  • 6:10 p.m. | Unequal and early: Mapping global disparities in cancers before age 50
    Tomi Akinyemiju, Duke University School of Medicine, Durham, North Carolina
  • 6:45 p.m. | The plastic paradox: Implications for cancer and chronic disease, and what we can do about it
    Leonardo Trasande, NYU Grossman School of Medicine, New York, New York

Poster Session A/Reception       

7:30-9 p.m. | Grand Salon Opera C

Thursday, December 11

CONTINENTAL BREAKFAST

7-8:00 a.m. | Grand Salon Foyer

Meet-the-Expert / Mentoring Roundtables Session

7-8 a.m. | Grand Salon Foyer

Conducting Translational Research: How to Get Started Andrew ChanHow to Get a Paper Published Zsofia Stadler
Choosing a Career Path: Academia vs Industry | Entrepreneurship Marat FudimHow to Write a Grant Ulrike (Riki) Peters
Balancing Clinical and Research responsibilities Zsofia Stadler, Karuna Ganesh, Andrew ChanStarting your Lab Karuna Ganesh


Plenary Session 1: Epidemiology of Early-Onset Cancer 

8-9:45 a.m. | Grand Salon Opera AB

Session Chairs: Timothy R. Rebbeck, Dana-Farber Cancer Institute, Boston, Massachusetts  

  • 8:05 a.m. | Trends in cancer mortality before the age of 50 with a focus on colorectal cancer
    Carlo LaVecchia, Università degli Studi di Milano, Milan, Italy 
  • 8:25 a.m. | Peeling the onion: Epidemiologic clues to the etiology of rising early-onset colorectal cancer
    Rebecca Siegel, American Cancer Society, Atlanta, Georgia
  • 8:45 a.m. | Environmental exposures and the rise of early onset cancers
    Mary Beth Terry, Columbia University Irving Medical Center, New York, New York
  • 9:05 a.m. | Risk prediction modeling for colorectal adenomas in persons under age 50: A risk-stratified approach to early onset colorectal cancer prevention* 
    Shria Kumar, University of Miami Miller School of Medicine, Miami, Florida
  • 9:15 a.m. | Co-occurring social determinants of endometrial cancer disparities in All of Us
    Oyomoare Osazuwa-Peters, Duke University School of Medicine, Durham, North Carolina 

Break 

10-10:15 a.m.

Plenary Session 2: Leading Hypotheses—Learning from Commonalities Across Diseases 

10:15 a.m.-12:00 p.m. | Grand Salon Opera AB

Session Chairs: Andrea Cercek, Memorial Sloan Kettering Cancer Center, New York, New York

  • 10:20 a.m. | Searching for a link in etiology across early-onset cancers
    Andrea Cercek
  • 10:40 a.m. | Drawing parallels to heart failure diagnosis and research
    Marat Fudim, Duke University, Durham, North Carolina
  • 11 a.m. | Early-life sugar restrictions and long-term health
    Tadeja Gracner, University of Southern California, Los Angeles, California
  • 11:20 a.m. | Methylation scores link the exposome to eoCRC 
    Silvana Maas, VHIO Vall D’Hebron Institute of Oncology, Barcelona, Spain 
  • 11:30 a.m. | Mutational signature profiling identifies a distinct subgroup of early-onset colorectal cancer associated with younger age at diagnosis, recent birth year and specific genomic features*
    Daniel Buchanan, University of Melbourne, Parkville, VIC, Australia

Lunch on Own/Free Time 

12:15-2 p.m. 

Plenary Session 3: Global Disparities in Early-Onset Cancer 

2-3:45 p.m. | Grand Salon Opera AB

Session Chair: Tomi Akinyemiju, Duke University School of Medicine, Durham, North Carolina

  • 2:05 p.m. | From place to person: an overview of global disparities in early-onset cancer
    Caitlin Murphy, University of Texas Houston School of Public Health, Houston, Texas
  • 2:25 p.m. | Racial/ethnic disparities across the early onset colorectal cancer continuum (in the US)
    Folasade P. May, University of California Los Angeles, Los Angeles, California 
  • 2:45 pm | Sociodemographic and clinical determinants associated with early-onset breast cancer
    Tara Friebel-Klingner, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ 
  • 3:05 p.m. | Uncovering the etiology of early-onset gastric cancer in Latinos through germline and tumor genomic profiling*
    Luis Carvajal-Carmona, UC Davis, Davis, California
  • 3:15 p.m. | Temporal trends in the incidence of obesity-associated cancers in Puerto Rico, 2000–2022: Disproportionate increases among younger adults*
    Carola T. Sánchez Díaz, University of Puerto Rico Comprehensive Cancer Center, San Juan, Puerto Rico

Poster Session b/Reception    

4:30-6 p.m. | Grand Salon Opera C

Evening off/Dinner on own 

6 p.m.

Friday, December 12

Continental Breakfast 

7-8 a.m. 

Meet-the-Expert / Mentoring Roundtables Session

7-8 a.m. | Grand Salon Foyer

Conducting Translational Research: How to Get Started Yin Cao, Elizabeth JaffeeGetting Tenure
Elizabeth Jaffee
EU/UK Collaborations
Carlo La Vecchia		Starting your Lab
Marcus Goncalves
How to Write a Grant Ruth Etzioni, Elaine Fuchs, Ashani WeeraratnaHow to Get a Paper Published Rebbeca Siegel

Plenary Session 4: Mechanisms of Early-Onset Carcinogenesis—Obesity and Metabolic Syndrome 

8-9:45 a.m. | Grand Salon Opera AB

Session Chair: Yin Cao, Washington University, St. Louis, Missouri

  • 8:05 a.m. | Born out of balance: Metabolism, mechanism, and the making of a new cancer generation
    Yin Cao
  • 8:25 a.m. | Modeling the impact of western diet components in early-onset colorectal cancer
    Marcus DaSilva Goncalves, NYU Langone Health, New York, New York
  • 8:45 a.m. | Integrative cancer population sciences to decipher the etiology of early-onset cancers
    Tomotaka Ugai, Harvard Medical School, Boston, Massachusetts
  • 9:05 a.m. | Incidence of early onset colorectal, kidney, uterine and pancreatic cancer by county-level obesity prevalence in the U.S., 2010-2022*
    Meredith Shiels, National Cancer Institute, Rockville, Maryland
  • 9:15 a.m. | Tumor-adjacent visceral adipose tissue displays an altered transcriptomic landscape in early-onset colorectal cancer patients: Results from the ColoCare Study*
    Victoria Bandera, University of Utah Huntsman Cancer Institute, Salt Lake City, Utah

Break

10-10:15 a.m.

Plenary Session 5: Mechanisms of Early-Onset Carcinogenesis—Exogenous Factors 

10:15 a.m.-12:30 p.m. | Grand Salon Opera AB

Session Chair: Riki (Ulrike) Peters, Fred Hutchinson Cancer Center, Seattle, Washington

  • 10:20 a.m. | Unveiling trends: Genetic, environmental, and molecular insights into early-onset colorectal cancer
    Riki (Ulrike) Peters
  • 10:40 a.m. | From the exposome to molecular profiling of early-onset colorectal cancers 
    Alberto Bardelli, IFOM, Italy
  • 11:00 a.m. | Early-life risk factors and colorectal cancer: Implications for explaining the rise in early-onset cancers
    Mingyang Song, Harvard School of Public Health, Brookline, Massachusetts
  • 11:20 a.m. | Contributions of the exposome to the rise in early onset cancers 
    Samir M. Hanash, MD Anderson Cancer Center, Houston, Texas
  • 11:40 a.m. | Early-life penicillin blooms colibactin-positive Escherichia coli and drives DNA damage and tumorigenesis*
    Max Van Belkum, Vanderbilt University School of Medicine, Nashville, Tennessee
  • 11:50 a.m. | Bugs in space: Spatial analysis of the immune-microbial axis in rectal cancer reveals a unique interface in young onset rectal cancers*
    Ryan B. Morgan, UT MD Anderson Cancer Center, Houston, Texas

Lunch on Own/Free Time 

12:30-2:30 p.m. 

Presentation of Awards to the Conference Cochairs

2:30-2:35 p.m. | Grand Salon Opera AB

Presented by: Elaine Fuchs, Rockefeller University, New York, New York

Plenary Session 6: Mechanisms of Early-Onset Carcinogenesis—Endogenous Mechanisms 

2:35-4:45 p.m. | Grand Salon Opera AB

Session Chair: Joachim Weischenfeldt, Rigshospitalet Copenhagen, Copenhagen, Denmark 

  • 2:40 p.m. | Mutational processes driving early-onset prostate cancer
    Joachim Weischenfeldt 
  • 3 p.m. | A complex TiME: How the aging tumor immune microenvironment governs tumor progression
    Ashani Weeraratna, Johns Hopkins University, Baltimore, Maryland
  • 3:20 p.m. | The role of pks⁺ E. coli in early-onset colorectal cancer
    Karuna Ganesh, Memorial Sloan Kettering Cancer Center, New York, New York
  • 3:40 p.m. | Cancer: A tango of miscommunication between oncogenic stem cells and their microenvironment
    Elaine Fuchs, Rockefeller University, New York, New York
  • 4 p.m. | Early-onset colorectal cancer is characterized by transcriptional changes indicating increased epithelial-mesenchymal transition and metastatic potential*
    Ana Anderson, Brigham and Women’s Hospital, Boston, Massachusetts
  • 4:10 p.m. | Transcriptomic and pathway analyses patterns in early-onset and late-onset microsatellite stable colorectal cancer: Results from the ORIEN Network* 
    Sheetal  Hardikar, University of Utah Huntsman Cancer Institute, Salt Lake City, UT  

Poster Session c/Reception   

5-6:30 p.m. | Grand Salon Opera C

Evening off/Dinner on own 

7 p.m. 

Saturday, December 13

Continental Breakfast 

7-8 a.m. 

Special Session: The NCI Early-Onset Cancer Initiative: Driving Discovery, Collaboration, and Patient Engagement

7:15-8:15 a.m. 

Organizer: LeeAnn Bailey (NCI)

Plenary Session 7: Early Detection and Screening 

8:30-10:15 a.m. | Grand Salon Opera AB

Session Chair: Luis Diaz, Memorial Sloan Kettering Cancer Center, New York, New York

  • 8:35 a.m. | Prevention of cancer in young adults
    Andrew T. Chan, Massachusetts General Hospital, Boston, Massachusetts
  • 8:55 a.m. | Multi-cancer early detection testing: Hope or hype? 
    Elizabeth O’Donnell, Dana-Farber Cancer Institute, Boston, Massachusetts
  • 9:15 a.m. | Early onset cancer incidence: A model for the role of diagnostic advances*
    Ruth Etzioni, Fred Hutchinson Cancer Center, Seattle, Washington
  • 9:35 a.m. | Distinct oral bacterial signatures in rectal cancer tumors associated with age of onset and treatment response*
    Nadim Ajami, UT MD Anderson Cancer Center, Houston, Texas
  • 9:45 a.m. | FIT for red flag signs and symptoms of early onset colorectal cancer: Low value or viable diagnostic tool*
    Daniel Sabater Minarim, UC San Diego Health, La Jolla, California

Break 

10:15-10:45 a.m.  

Plenary Session 8: Opportunities for Interception 

10:45 a.m.-12:15 p.m. | Grand Salon Opera AB

Session Chair: Elizabeth Jaffee, Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland

  • 10:50 a.m. | Oncogene-targeted vaccines for cancer interception 
    Elizabeth Jaffee
  • 11:10 a.m. | Luis Diaz, Memorial Sloan Kettering Cancer Center, New York, New York
  • 11:30 a.m. | Identification of inherited cancer syndromes: Re-defining early-onset cancers
    Zsofia K. Stadler, Memorial Sloan Kettering Cancer Center, New York, New York
  • 11:50 a.m. | Supplement and medication use in early-onset colorectal cancer: An analysis of the Ohio colorectal cancer prevention initiative*
    Holli Loomans-Kropp, The Ohio State University Wexner Medical Center, Columbus, Ohio
  • 12 p.m. | Multidimensional assessment of toxicities and survivorship among people with early-onset colorectal cancer – Results from the ColoCare Study*
    Jane Figueiredo, Cedars-Sinai Medical Center, Los Angeles, California

Panel Discussion: Future Directions 

12:30-1:30 p.m. | Grand Salon Opera AB

Panelists:
Elizabeth M. Jaffee, Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland
Timothy R. Rebbeck, Dana-Farber Cancer Institute, Boston, Massachusetts
Luiz Diaz, Memorial Sloan Kettering Cancer Center, New York, NY   

Closing Remarks 

1:30-1:45 p.m.

Departure 

1:45 p.m.