Indigenous American Ancestry May Be Associated with HER2-positive Breast Cancer
PHILADELPHIA – An increased proportion of Indigenous American (IA) ancestry was associated with a greater incidence of HER2-positive breast...
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Breast Density, Microcalcifications, and Masses May be Heritable Traits
Some mammographic features are associated with increased breast cancer risk PHILADELPHIA – An analysis of a large Swedish cohort...
HER2-targeted Therapy Trastuzumab Deruxtecan Shows Early Promise in Patients with Non-breast and Non-gastric Cancers
PHILADELPHIA – A HER2-targeted antibody-drug conjugate, fam-trastuzumab deruxtecan-nxki (Enhertu), showed signs of clinical activity in multiple non-breast/non-gastric cancer types,...
Artificial Intelligence May Help Predict Responses to Systemic Therapies in Patients With Non-small Cell Lung Cancer
PHILADELPHIA – Using standard-of-care computed tomography (CT) scans in patients with advanced non-small cell lung cancer (NSCLC), researchers utilized...
Young Women with Breast Cancer May Face Financial Hardship After Diagnosis
Cancer experience affects work performance, career decisions, and personal debt PHILADELPHIA – Young women with breast cancer experienced substantial...
Low-nicotine Cigarette Use May Not Lead to Compensatory Smoking
PHILADELPHIA – The use of cigarettes with low nicotine content did not result in compensatory smoking, according to results...
Single Copy Loss of a Gene Cluster May Contribute to Initiation and Progression of Multiple Myeloma in Preclinical Study
PHILADELPHIA – The loss of one copy of the miR15a/miR16-1 gene cluster promoted initiation and progression of multiple myeloma...
Infection With Dengue Virus May Increase the Risk of Leukemia
PHILADELPHIA – Compared with individuals without a history of dengue virus infection, those previously infected with the virus had...
Peripheral Blood From Patients with Metastatic Solid Tumors Is A Source of p53-reactive T cells
PHILADELPHIA — T cells targeting p53 hotspot mutations can be harvested from peripheral blood of patients with metastatic solid epithelial cancers, according to...
Targeted Therapy Combination Shows Promising Antitumor Activity in Aggressive Meningiomas
PHILADELPHIA — The targeted therapy combination of the mTOR inhibitor everolimus (Afinitor) and the somatostatin agonist octreotide (Sandostatin) yielded...