BRAF Inhibitor Shows Promising Results in Pediatric Patients with Low-Grade Glioma
PHILADELPHIA — Dabrafenib (Tafinlar), a BRAF inhibitor approved to treat certain types of adult melanoma, showed activity in pediatric...
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Anti-CTLA-4 Antibody Tremelimumab Shows Efficacy in Patients With Metastatic Bladder Cancer
PHILADELPHIA — Treatment with the investigational anti-CTLA-4 agent tremelimumab showed clinical responses in patients with pretreated metastatic bladder cancer,...
Commercial Prognostic Tests for Prostate Cancer May Not Be Accurate in African American Men
PHILADELPHIA — Commercial gene expression tests that guide treatment decisions for prostate cancer may not accurately predict risk of...
Oncotype DX Breast Recurrence Score Reveals Sex-related Differences in Mortality Prediction in Patients With Early-stage ER-positive Breast Cancer
PHILADELPHIA — The associations of breast cancer recurrence scores (RS) with mortality measured using Oncotype DX, a commercial diagnostic...
Long-term Survival Rate for Subset of Patients With Advanced Melanoma Following BRAF- and MEK-targeted Treatment Combination Higher Than Historical Rate
PHILADELPHIA — Almost 40 percent of patients with metastatic melanoma harboring BRAF V600E mutations who were treated with a...
Antibody-Drug Conjugate Shows Early Promise in Patients with Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
PHILADELPHIA – ADCT-402, an investigational antibody-drug conjugate, showed signs of clinical activity in patients with relapsed/refractory B-cell non-Hodgkin lymphoma,...
Monoclonal Antibody Treatment Combined with Induction Chemotherapy Yielded Promising Outcomes in High-Risk Neuroblastoma
PHILADELPHIA – Combining an investigational anti-GD2 monoclonal antibody with induction chemotherapy yielded promising two-year event-free survival in pediatric patients...
Cancer Incidence and Most Common Types Vary Among American Indians and Alaska Natives
Rates show significant variation by geographic regions for these groups than for whites PHILADELPHIA: The nation’s American Indian and...
Patients With Metastatic Colorectal Cancer Harboring Certain BRAF Mutations May Respond to Anti-EGFR Therapy
PHILADELPHIA – Patients with metastatic colorectal cancer harboring a subset of non-V600 mutations in the BRAF gene, known as...
A Liquid Biopsy Test Can Identify Patients Who May Respond to Immune Checkpoint Blockade
Test employs error correction to increase accuracy PHILADELPHIA – A new liquid biopsy test could detect microsatellite instability (MSI)...