Genomic Profiling of Pediatric Cancer May Expand Treatment Options for Patients Experiencing a Relapse
Patients were matched to therapies targeting specific mutations found in their cancers PHILADELPHIA – Genomic sequencing of tumors from...
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T-cell Responses May Help Predict Protection Against SARS-CoV-2 Infection in Individuals With and Without Cancer
PHILADELPHIA – T-cell responses directed against the receptor-binding domain of the SARS-CoV-2 spike protein were associated with protection from...
Newly Characterized Mutation May Define Novel Pediatric AML Subtype
PHILADELPHIA – A new mutation was identified in 9 percent of relapsed cases of pediatric acute myeloid leukemia (AML)...
Rural Residents Tend to Hold Fatalistic Beliefs and Perceive More Cancer-related Information Overload Than Urban Residents
PHILADELPHIA – Compared to U.S. urban adults, rural adults were more likely to think fatalistically about cancer and feel...
Younger Individuals May Have the Highest Risk of Presenting with Distant-stage Colorectal Cancer
Risk may be greatest among young Black and Hispanic subgroups PHILADELPHIA – Individuals between 20 and 39 years old...
Combination Therapies May Improve Outcomes Due to Independent, Rather Than Synergistic or Additive, Drug Action
Findings have implications for future cancer clinical trial design involving immune checkpoint inhibitors PHILADELPHIA – Independent drug action, not...
Survival Rate of Adult Patients With Relapsed Acute Lymphoblastic Leukemia After Hematopoietic Cell Transplantation Has Steadily Increased Over the Past Two Decades
Study reports progressive improvement in the outcomes of patients carrying the Philadelphia chromosome PHILADELPHIA – For patients with acute...
The Inaugural WHO Classification of Childhood Tumors Will Provide a Unified, Updated Resource for the Diagnosis of Pediatric Cancers
Resource reflects transition from a mostly microscopy-driven to a molecularly driven classification system PHILADELPHIA – The first classification of...
Sequencing of Bone Marrow DNA May Predict Leukemia Relapse After CAR-T Therapy With Sufficient Time to Intervene
Next-generation sequencing for minimal residual disease was highly sensitive and more accurate than flow cytometry and monitoring of B-cell...
Fasting-mimicking Diet Is Safe, May Modulate Metabolism and Boost Antitumor Immunity in Cancer Patients
PHILADELPHIA – A diet involving short-term, severe calorie restriction was safe, feasible, and resulted in a decrease of blood...