The Lung Microbiome May Affect Lung Cancer Pathogenesis and Prognosis
PHILADELPHIA – Enrichment of the lungs with oral commensal microbes was associated with advanced stage disease, worse prognosis, and...
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Genetic Alterations May Contribute to Greater Prostate Cancer Incidence and Mortality Among African American Men
PHILADELPHIA – Prostate cancer tumors from African American men had higher frequencies of certain genetic alterations that may be...
Response to Adjuvant Bevacizumab Among Patients With Resected Melanoma May Vary By Age
sFRP2, but not VEGF, may promote angiogenesis in older patients with melanoma PHILADELPHIA – Younger patients with resected melanoma...
Women With Cervical Cancer May Have Increased Risk of Injury During Diagnostic Workup
PHILADELPHIA – Among women participating in cervical cancer screening in Sweden, those with a diagnosis of invasive cervical cancer...
Circulating Tumor DNA May Predict Clinical Outcomes with First-line, but not Second-line, Immunotherapy for Melanoma
PHILADELPHIA – Baseline levels of circulating tumor DNA (ctDNA) predicted responses to first-line, but not second-line, immune checkpoint inhibition...
Combined Inhibition of HDAC and mTOR May Improve Outcomes in Patients with Relapsed/Refractory Hodgkin Lymphoma
PHILADELPHIA – The histone deacetylase (HDAC) inhibitor vorinostat (Zolinza) in combination with the mTOR inhibitor sirolimus (Rapamune) or everolimus...
Urine-based Liquid Biopsy Test Outperforms Urine Cytology in Detecting Bladder Cancer
PHILADELPHIA – Analysis of DNA copy number variants (CNVs) in the cells exfoliated in urine showed better sensitivity and...
Counties with Persistent Poverty Rates Experience Higher Rates of Cancer Deaths
PHILADELPHIA – Residents of counties that experience persistent poverty face a disproportionately high risk of cancer mortality, according to...
Proton Pump Inhibitors May Affect Responses to Atezolizumab in Patients with Urothelial Cancer
PHILADELPHIA – Proton pump inhibitor (PPI) use was associated with worse outcomes in patients with urothelial cancer treated with...
Radiation Treatment for Childhood or Young Adult Primary Cancer Linked to Worse Breast Cancer-specific Survival In Premenopausal Women
PHILADELPHIA – Among premenopausal women with breast cancer, those who were previously treated with radiation for a primary childhood,...