AACR Expresses Sincere Appreciation to NIH Director Francis Collins
PHILADELPHIA — The American Association for Cancer Research (AACR) today expressed its gratitude to Francis S. Collins, MD, PhD,...
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Inhibition of the Aurora Kinase A Protein May Help Overcome Lung Cancer Resistance to KRAS Inhibition
PHILADELPHIA – In preclinical models, combining an investigational Aurora Kinase A (AURKA) inhibitor with a KRAS inhibitor or a...
Adding ErbB Tyrosine Kinase Inhibitor to KRAS Inhibitor May Help Circumvent Lung Cancer Resistance to Prior Therapies
PHILADELPHIA – Combination of the KRAS inhibitor sotorasib (Lumakras) with afatinib, a pan-ErbB tyrosine kinaseinhibitor, was feasible in treating...
DNA Alkylation Drug May Improve Outcomes for Adolescents and Young Adults With Central Nervous System Tumors
PHILADELPHIA – In a phase II clinical trial, the drug 4-demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) improved survival for some adolescent and young...
A Peptide-drug Conjugate that Targets the Acidic Environment of Cancer Cells May Improve the Efficacy of Immunotherapy
PHILADELPHIA – A peptide-drug conjugate that targets the acidic environment of cancer cells enhanced the efficacy of immune checkpoint...
Darolutamide Showed Similar Benefits for Black/African American Patients as Observed in the Overall Population of the ARAMIS Trial
PHILADELPHIA – Black/African American patients with prostate cancer who were treated with the androgen receptor inhibitor darolutamide (Nubeqa) had...
Some Pancreatic Cancer Clinical Trial Eligibility Criteria May Be More Likely to Disqualify Black Patients
Modifying criteria could help researchers enroll more Black patients in trials PHILADELPHIA – A simulated pancreatic cancer clinical trial...
Chronic Stress May Impact Treatment Completion and Survival Outcomes in Patients with Breast Cancer
PHILADELPHIA – Elevated allostatic load was associated with a lower likelihood of completing chemotherapy and a lower overall survival...
Nasopharyngeal Cancer Incidence Varies Widely Among Different Ethnic Subgroups of Asian Americans
Data could help identify factors that contribute to higher risk PHILADELPHIA – Chinese Americans and Laotian Americans were over...
Cervical Cancer Screening Tailored for Transgender Men and Nonbinary People Encouraged Participation
PHILADELPHIA – A pilot program that provided transgender men and nonbinary people with cervical cancer screening tailored to their...