Single-cell RNA Sequencing Provides Comprehensive Map of Acute Myeloid Leukemia Cell States
Study establishes a reference for normal hematopoietic cell differentiation and identifies novel acute myeloid leukemia cell states with potential...
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American Association for Cancer Research Inaugurates New Leadership During AACR Annual Meeting 2025
Lillian L. Siu, MD, FAACR, begins term as AACR President CHICAGO – The members of the American Association for...
Oral HER2-targeted Therapy Zongertinib Demonstrates Clinical Benefit in Advanced HER2-mutated Lung Cancer
CHICAGO – Zongertinib, a human epidermal growth factor receptor 2 (HER2)-targeted tyrosine kinase inhibitor, elicited durable responses in patients...
A Liquid Biopsy-based Assay Could Detect Recurrence Prior to Imaging in Patients With Resectable Colorectal Cancer
CHICAGO – An ultrasensitive circulating tumor DNA (ctDNA)-based liquid biopsy assay detected signs of recurrence prior to imaging and...
AI-driven Analysis of Digital Pathology Images May Improve Pediatric Sarcoma Subtyping
CHICAGO – An artificial intelligence (AI)-based model accurately classified pediatric sarcomas using digital pathology images alone, according to results...
A Topical BRAF-inhibiting Gel May Mitigate Acneiform Rash in Patients Receiving EGFR-targeted Therapy for Colorectal Cancer
CHICAGO – Patients with colorectal cancer who had acneiform rash and applied LUT014 gel, an investigational topical BRAF inhibitor,...
AI-driven Biomarker Model May Improve Detection of Cancer Cachexia
CHICAGO – A multimodal, artificial intelligence (AI)-driven model that analyzes routinely collected imaging and clinical information led to more...
Pretrained Machine Learning Models May Help Accurately Diagnose Nonmelanoma Skin Cancer in Resource-limited Settings
CHICAGO – Artificial intelligence models, pretrained on vast datasets, significantly outperformed a standard baseline model in identifying nonmelanoma skin...
Off-the-shelf CAR Natural Killer Cell Therapy with Logic Gates Elicits Complete Remissions in Relapsed or Refractory Blood Cancers
CHICAGO – Several patients with acute myeloid leukemia (AML), who were treated with SENTI-202, a first-in-class chimeric antigen receptor...
Adjuvant PD-1 Blockade for Mismatch Repair-deficient Solid Cancers Directed by ctDNA Status Delivers Clinical Benefit
CHICAGO – Pembrolizumab (Keytruda), an anti-PD-1 antibody, cleared minimal residual disease and protected against recurrence in patients with DNA...