A distinguished translational scientist, Dr. Witte has made significant contributions to understanding human leukemias, immune disorders, and epithelial cancer stem cells, research of which has resulted in improved clinical therapies. Most notably, he pinpointed the molecular consequences of the Philadelphia (Ph) chromosome abnormality present in chronic myelogenous leukemia (CML) and related types of leukemia. Alongside this discovery, he defined the tyrosine kinase activity of the ABL gene, while one of his graduate students at the time, James Konopka, discovered the presence of abnormal BCR-ABL gene fusions in human leukemias. These collective findings played a crucial role in the subsequent development of kinase-targeted therapies, including imatinib, which remains the frontline treatment for Ph+ CML.
In addition to his research involving ABL, Dr. Witte also co-discovered Bruton ‘s tyrosine kinase (BTK). This particular kinase is essential for B-cell maturation and when mutated, results in the onset of the immunodeficiency disease, X-linked agammagloblulinemia. Recent studies involving this protein have resulted in the FDA approval of ibrutinib, a selective BTK inhibitor, approved for the treatment of chronic lymphocytic leukemia and mantle cell lymphoma.
Dr. Witte’s more recent work has concentrated on the prostate gland and on defining the epithelial stem cell populations that contribute to prostate cancer. Through the use of molecular imaging and tissue recombination modeling techniques in mice, Dr. Witte continues to define the characteristics of these cancer cell populations and has since begun to analyze how these cells contribute to bone metastases in patients with advanced stages of prostate cancer. Dr. Witte continues this research, in part, through his position as co-leader of the Stand Up to Cancer Dream Team, “Targeting Adaptive Pathways in Metastatic Treatment-Resistant Prostate Cancer.”
2016-present University Professor, University of California, Los Angeles
2016 Association of American Medical Colleges Award for Distinguished Research in Biomedical Sciences
2016 Stanford Medical School Kornberg-Berg Lifetime Achievement Award in Biosciences
2015 AACR G.H.A. Clowes Memorial Award
2014 The Rowley Prize awarded by the Intl Chronic Myeloid Leukemia Foundation 2011-2017 President ‘s Cancer Panel (U.S. Presidential Appointment)
2011 Nakahara Memorial Lecture Prize
2010-2013 Board of Directors, AACR
2009 Cotlove Lectureship, Academy of Clinical Laboratory Physicians and Scientists
2003 Elected Member, Institute of Medicine
2003 de Villiers International Achievement Award, Leukemia and Lymphoma Society
2000 Warren Alpert Prize
1999 50th Anniversary Commemorative Award, Leukemia Society of America
1997 Elected Member, National Academy of Sciences, Washington, D.C.
1996 Elected Fellow, American Academy of Arts and Sciences
1993 Dameshek Prize, American Society of Hematology
1991 AACR-Richard and Hinda Rosenthal Award
1990 Milken Family Foundation Award for Basic Cancer Research
1985 March of Dimes Basil O’Conner Scholar Award
1976 MD, Stanford University School of Medicine