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New AACR Project GENIE Paper Alert: Genomic Landscapes and Hallmarks of Mutant RAS in Human Cancers

Over the past four years, a multi-disciplinary team brought together by AACR Project GENIE from Johns Hopkins Kimmel Cancer Center, The Johns Hopkins University School of Medicine, Memorial Sloan Kettering Cancer Center, Dana Farber Cancer Institute, Vanderbilt University School of Medicine, and Amgen Inc. has been studying the distribution and co-mutations of KRAS, NRAS, and HRAS mutant cancers.

The work is now published in Cancer Research (September 8, 2022) and represents the largest study of RAS genomic architecture to date, leveraging NGS data from >600,000 mutations and >66,000 tumors across 51 cancer types. 

Moreover, the KRAS Study Team made the cover of Cancer Research!

Read the full text.

Overall, the study assessed the genomic landscape of RAS mutant tumors in a pan-cancer manner and with a RAS mutant allele-specific resolution, considering gene-gene interactions individually as well within gene families and pathways and accounting for host and tumor confounders. The findings provide insights into the genomic architecture of RAS mutant cancers and may serve as a blueprint for mapping therapeutic vulnerabilities for mutant RAS. 

Given the vast array of findings, the team has put together an app titled RAS-hallmarks for interactive data visualization.

Congratulations to the members of the KRAS Study team!

Project Leadership 

  • Valsamo (Elsa) Anagnostou (JHU) 
  • Christine Lovly (VICC) 
  • Mark Awad (DFCI) 
  • Greg Riely (MSKCC)   

  Project Statistics and Data Analysis: 

  • Robert Scharpf (JHU) 
  • Chenguang Wang (JHU) 
  • Jacob Fiksel (JHU)   
  • Christopher Cherry (JHU) 
  • James White (JHU) 
  • Blair Landon (JHU) 
  • Marta Majcherska-Agrawal (JHU) 
  • Paola Ghanem (JHU) 

Computational Support: 

  • Alexander Baras (JHU) 
  • Jordan Anaya (JHU) 

GENIE Site Project Managers 

  • Biagio Ricciuti (DFCI) 
  • Michele Lenoue-Newton (VICC) 
  • Hira Rizvi (MSKCC, former) 

Sage Bionetworks 

  • Xindi Guo 
  • Thomas Yu  
  • Haley Hunter-Zinck (former) 
  • Kristen Dang (former) 

Amgen, Inc. 

  • Hil Hsu 
  • Shivani Aggarwal (former) 
  • Huakang Tu (former) 
  • Leon Raskin (former) 
  • Andrew Park 
  • David Anders 
  • Victoria Chia 
  • Xuena Wang 

Overall Project Support 

  • Kathryn Arbour (MSKCC) 
  • Marilyn Holt (VICC) 
  • Julia Rudolph (MSKCC) 
  • Deepti Venkatraman (DFCI) 
  • Joao Alessi (DFCI) 
  • Jacklynn Egger (MSKCC) 

GENIE Coordinating Center 

  • Jocelyn Lee