CREB1 Identified as Potential Therapeutic Target for the Treatment of Pancreatic Cancer
PHILADELPHIA – Preclinical experiments using cell lines, genetic mouse models, and human pancreatic tumor tissue identified the transcription factor...
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Early-onset Colorectal Cancers from Patients of Different Races May Exhibit Distinct Genetic Features
PHILADELPHIA – Racial differences in genetic mutations were observed among early-onset colorectal cancers (CRC), according to data presented during...
Bispecific Fusion Protein Tebentafusp Significantly Improves Overall Survival in Patients With Metastatic Uveal Melanoma
PHILADELPHIA – Compared with available standard therapies, including immune checkpoint inhibitors, treatment with the bispecific fusion protein tebentafusp nearly...
Ovarian Cancer Patients Face Increased Risk of Mental Illness
Higher rates of anxiety and depression were associated with higher mortality risk PHILADELPHIA – Women diagnosed with ovarian cancer...
Bispecific CAR T-cell Therapy Shows Early Promise for Relapsed or Refractory B-cell Lymphoma
PHILADELPHIA – Bispecific anti-CD19/CD20 chimeric antigen receptor (CAR) T-cell therapy was well tolerated and showed signs of clinical efficacy...
Oncolytic Herpesvirus Shows Early Promise in Pediatric Patients with High-grade Glioma
PHILADELPHIA – Treatment with a modified herpesvirus in combination with radiation therapy was well tolerated and showed signs of...
Neoadjuvant Nivolumab plus Chemotherapy Increased Pathological Complete Response Rate in CheckMate-816 Lung Cancer Trial
PHILADELPHIA – Adding nivolumab (Opdivo) to chemotherapy as neoadjuvant treatment for patients with resectable non-small cell lung cancer (NSCLC)...
Rare Pathogenic Germline Variants Were Observed in Sporadic Pediatric Neuroblastoma Cases and Were Inherited
PHILADELPHIA – Pediatric patients with sporadic neuroblastoma harbored rare pathogenic variants in cancer predisposition genes that were inherited and...
Cancer Aneuploidy May Predict Responses to Immunotherapy in Patients with Non-small Cell Lung Cancer
PHILADELPHIA – Lower levels of cancer aneuploidy were associated with more favorable outcomes after immune checkpoint inhibition in patients...
AACR Announces Fellows of the AACR Academy Class of 2021
PHILADELPHIA – The American Association for Cancer Research (AACR) today announced its newly elected class of Fellows of the...