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Opening the Barriers in Glioblastoma with Tumor Treating Fields

Opening the Barriers in Glioblastoma with Tumor Treating Fields

Treatment options for brain cancers, including aggressive glioblastoma, are limited despite the availability of several chemotherapeutic drugs due to the inability of these drugs to cross the blood-brain barrier (BBB). AACR-Novocure grantee Dr. Carsten Hagemann and his team showed that the use of low-intensity alternating electric fields known as Tumor Treating Fields (TTFields), an FDA-approved treatment modality, can facilitate drugs crossing the BBB. Using multiple models, they elucidated the mechanisms driving this action.

A Novel Target to Mitigate Chemobrain

A Novel Target to Mitigate Chemobrain

Chemotherapy-induced cognitive impairment (CICI), also known as chemobrain, can affect up to 75% of patients during treatment. Recipient of the 2019 The Bosarge Family Foundation-Waun Ki Hong Scholar Award for Regenerative Cancer Medicine Alfredo Oliveros, PhD, and his colleagues showed that inhibiting adenosine A2A receptor signaling can prevent cisplatin-induced cognitive impairment.