MONDAY, March 14, 2021

Welcome and Keynote Lectures
5:30-7 p.m.
Session Chair: Andriy Marusyk, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida

Welcome from Cochairs
Robert J. Gillies, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida

Title to be announced
Robert A. Gatenby, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida

Title to be announced
Charles Swanton, The Francis Crick Institute and UCL Cancer Institute, London, United Kingdom

Opening Reception
7-9 p.m.                    

TUESDAY, March 15, 2021

Breakfast
7-8 a.m.

Plenary Session 1: Longitudinal Dissection of Resistance Evolution
8-10:15 a.m.
Session Chair: Marco Gerlinger, The Institute of Cancer Research, London, United Kingdom

Darwinian and non-Darwinian evolution of cancer drug resistance
Marco Gerlinger

Title to be announced
Trever G. Bivona, University of California San Francisco, San Francisco, California

Additional speaker to be announced

Short talks from proffered abstracts

Break
10:15-10:45 a.m.      

Panel Discussion: Genetic, epigenetic and functional heterogeneity in cancer: which one(s) can we call evolution?
10:45-11:45 a.m.  
Moderator: Robert J. Gillies, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida

Robert A. Gatenby, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida

Charles Swanton, The Francis Crick Institute and UCL Cancer Institute, London, United Kingdom

Additional Panelists to be Announced

Lunch on own
11:45 a.m.-2 p.m.    

Plenary Session 2: Clonal Evolution, Part I
2-4 p.m.

Title to be announced
Iñigo Martincorena, Wellcome Sanger Institute, Hinxton, United Kingdom

Outcompeting cancer
Louis M. Vermeulen, Academic Medical Center, Amsterdam, The Netherlands

Additional speakers to be announced

Break
4-4:15 p.m.

Plenary Session 3: Generation of Genomic and Epigenomic Diversity
4:15-6:15 p.m.
Session Chair: Rong Li, Johns Hopkins University, Baltimore, Maryland

Models of mutagenesis and carcinogenesis by human APOBEC3 enzymes 
Reuben S. Harris, University of Minnesota, Minneapolis, Minnesota

Title to be announced
Andrew P. Feinberg, Johns Hopkins University, Baltimore, Maryland

Title to be announced
Susan M. Rosenberg, Baylor College of Medicine, Houston, Texas

Short talks from proffered abstracts

POSTER SESSION A / RECEPTION
6:30-8:30 p.m.           

WEDNESDAY, March 16, 2021

Breakfast
7-8 a.m.            

Plenary Session 4: Microenvironmental Selection
8-10 a.m.

Aging, tissue ecology, and the evolution of cancer within us 
James V. DeGregori, University of Colorado, Aurora, Colorado

Mapping malignant differentiation topographies with single cell multi-omics
Daniel A. Landau, Weill Cornell Medicine, New York, New York

Additional speaker to be announced

Short talks from proffered abstracts

Break
10-10:30 a.m.

Plenary Session 5: Mechanisms and Dynamics of Resistance Emergence, Part I
10:30 a.m.-12:30 p.m.
Session Chair: Andriy Marusyk, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida

Resistance to targeted therapies as a gradual, multifactorial adaptation to inhibitor-specific selective pressures
Andriy Marusyk

Additional speakers to be announced

Short talks from proffered abstracts

AACR Cancer Evolution Working Group Session (Lunch Provided)
12:30-2 p.m.

Plenary Session 5: Mechanisms and Dynamics of Resistance Emergence, Part II
2-5 p.m.
Session Chair: Ivana Bozic, University of Washington, Seattle, WAshington

Speakers to be announced

Short talk from proffered abstracts

Break
3:15.-3:30 p.m.                    

Plenary Session 5: Mechanisms and Dynamics of Resistance Emergence, Part II (continued)
3:30-5 p.m.

Single-cell analysis of drug resistance, cellular memory, and plasticity in cancer
Sydney Sheffer, University of Pennsylvania, Philadelphia, Pennsylvania

Evolutionary dynamics of resistance to cancer therapy
Ivana Bozic, University of Washington, Seattle, Washington

Short talks from proffered abstracts

Poster Session B / Reception
5-7 p.m.

EVENING OFF / Dinner on Own
7 p.m.

THURSDAY, March 17, 2021

Breakfast
7-8 a.m.

Plenary Session 6: Evolutionary Guided (Adaptive) Therapy to Prevent Emergence of Resistance
8-9:45 a.m.
Session Chair: Robert J. Gillies, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida

Title to be announced
Rong Li, Johns Hopkins University, Baltimore, Maryland

Title to be announced
Alberto Bardelli, Candiolo Cancer Institute IRCCS, University of Turin, Italy

Selection for a glycolytic phenotype
Robert J. Gillies

Short talk from proffered abstracts

Break
9:45-10:15 a.m.     

Plenary Session 7: Clonal Evolution, Part II
10:15 a.m.-12:15 p.m.  
Session Chair: Christina Curtis, Stanford University,  Stanford, California

Decoding responses to chemotherapy in triple-negative breast cancer with single cell genomics
Nicholas E. Navin, The University of Texas MD Anderson Cancer Center, Houston, Texas

Quantifying clonal evolution through treatment and metastasis
Christina Curtis

Additional speaker to be announced

Short talks from proffered abstracts

Closing Remarks
12:15 p.m.        

James V. DeGregori, University of Colorado, Aurora, Colorado