In This Section

Program

Please note that this meeting will take place as an in-person event in Vancouver and will not live-stream content for virtual participation. The meeting content will be recorded and made available as an on-demand program after the conference. Please see the registration page for details.

All presentations are scheduled to be live, in-person presentations at the date and time specified below unless noted otherwise. Program in progress.

*-Short talk from proffered abstract

Monday, March 1

Tuesday, March 2

wednesday, March 3

Monday, March 1

REGISTRATION

4-8 p.m.

Welcome and Keynote Lectures 

3:30-6:30 p.m.

  • 3:30 p.m. | Keynote Speaker
    Igniting inflammation with cGAS
    Zhijian (James) Chen, UT Southwestern, Dallas, Texas
  • 4:15 p.m. | Keynote Speaker
    Christina Curtis, Stanford University, Stanford, California

Break

5-5:15 p.m.

Plenary Session 1: Genomic Mechanisms of Chromosomal Instability

5:15-7 p.m.

  • 5:15 p.m. | Marcin Imielinski, New York University, New York, New York
  • 5:45 p.m. | Sarah McLelland, Queen Mary’s University, London, United Kingdom
  • 6:15 p.m. | Sohrab Shah, Memorial Sloan Kettering Cancer Center, New York, New York

Short talks selected from proffered abstracts

Opening Reception and Poster Session A 

8-9 p.m.

Tuesday, March 2

Continental Breakfast

7-8 a.m.

Plenary Session 2: Mechanisms of DNA Damage and Replication Stress Responses

8-10 a.m.

  • 8 a.m. | Sharon Cantor, UMass Chan Medical School, Worcester, Massachusetts
  • 8:30 a.m. | Mitotic DNA damage tolerance and repair
    Daniel Durocher, Lunenfeld-Tanenbaum Research Institute, Toronto, Ontario
  • 9 a.m. | ATM safeguards DNA replication at endogenous base lesions: from molecular mechanism to therapeutic opportunity
    Ross Chapman, University of Oxford, Oxford, United Kingdom

Short talks selected from proffered abstracts

Break

10-10:30 a.m.

Plenary Session 3: Mechanisms of Mutagenesis

10:30 a.m.– 12:30 p.m.

  • 10:30 a.m. | Reuben Harris, UT Health Science Center at San Antonio, San Antonio, Texas
  • 11 a.m. | Andre Nussenzweig, National Institute of Health, Bethesda, Maryland
  • 11:30 a.m. | Ubiquitin signalling in replicative DNA damage processing
    Helle D. Ulrich, Institute of Molecular Biology (IMB), Mainz, Germany
  • 12 p.m. | APOBEC3A-mediated mutagenesis promotes metastatic cancer progression
    Abby Green, Washington University School of Medicine, St. Louis, Missouri

Lunch on Own / Free Time

12:30-2 p.m.

Plenary Session 4: ecDNA and Repeat Stability

2-4 p.m.

  • 2 p.m. | Agnel Sfeir, Memorial Sloan Kettering Cancer Center, New York, New York
  • 2:30 p.m. | Peter Ly, UT Southwestern, Dallas, Texas
  • 3 p.m. | Zhao Zhang, Duke University, Durham, North Carolina
  • 3:30 p.m. | Heterochromatin repair mechanisms
    Irene Chiolo, University of Southern California, Los Angeles, California

Break

4-4:15 p.m.

Plenary Session 5: Genome Instability and the Immune Response

3:30-5:30 p.m.

  • 4:15 p.m. | Roger Greenberg, University of Pennsylvania, Philadelphia, Pennsylvania
  • 4:45 p.m. | Aneuploidy: insights from the immune system
    Nicolas Manel, Institut Curie INSERM, Paris, France
  • 5:15 p.m.| Karlene Cimprich, Stanford University, Stanford, California

Short talks selected from proffered abstracts

Poster Session B

7:15-9 p.m.

Wednesday, March 3

Continental Breakfast

7-8 a.m.

Plenary Session 6:  Translational Application of Chromosomal Instability (Diagnostics or Drugs) Targeting Genomically Unstable Cancers

8-9:30 a.m.

  • 8 a.m. | Samuel Aparicio, BC Cancer, Vancouver, British Columbia, Canada
  • 8:30 a.m. | Dipanjan Chowdhury, Dana Farber Cancer Institute, Boston, Massachusetts
  • 9 a.m. | Extrachromosomal DNA (ecdna): Cancer’s Dynamic Circular Genome
    Paul Mischel, Stanford University, Stanford, California

Break

9:30-9:45 a.m.

Plenary Session 7: Chromosome Instability Consequences Syndromes

9:45-11:15 a.m.

  • 8:45 a.m. | Alan D’Andrea, Dana Farber Cancer Institute, Boston, Massachusetts
  • 10:15 a.m. | A link between innate immune signaling and genome instability
    John Petrini, Memorial Sloan Kettering Cancer Center, New York, New York
  • 10:45 a.m. | Using copy number alterations as biomarkers in oral cancers
    Agata Smogorzewska, Rockefeller University, New York, New York

Break

11:15-11:30 a.m.

Plenary Session 8: Keynote Session: Advances and Challenges in Drug Development

11:30 a.m.-1 p.m.

  • 11:30 a.m. | Biomarker-driven therapeutic advances in targeting DNA damage and replication Stress responses
    Timothy Yap, MD Anderson Cancer Center, Houston, Texas
  • 11:50 a.m. | Michael White, Ideaya Biosciences, South San Francisco, California
  • 12:10 p.m. | Liz Swisher, University of Washington

closing remarks

1 p.m.