In This Section

Program

Please note that this meeting will take place as an in-person event in Philadelphia and will not live-stream content for virtual participation. The meeting content will be recorded and made available as an on-demand program after the conference. Please see the registration page for details.

All presentations are scheduled to be live, in-person presentations at the date and time specified below unless noted otherwise. Program in progress.

*-Short talk from proffered abstract

Monday, March 23

TUESDAY, MARCH 24

WEDNESDAY, MARCH 25

Monday, March 23

REGISTRATION

3-8 p.m. | Grand Ballroom Foyer

WELCOME AND OPENING Keynotes

5-6:15 p.m. | Grand Ballroom Salon HIJ

  • 5 p.m. | Welcome from Co-Chairs
    Michelle Monje, Stanford University, Stanford, California
  • 5:05 p.m. | Introduction of Keynote Speaker 1
    Michelle Monje
  • 5:10 p.m. | How to target malignant neural networks in brain cancer
    Frank Winkler, Heidelberg University, Heidelberg, Germany 
  • 5:40 p.m. | Introduction of Keynote Speaker 2
    Mario Suva, Massachusetts General Hospital, Boston, Massachussetts
  • 5:45 p.m. | The role of injury programs in gliomagenesis
    Simona Parrinello, University College London (UCL) Cancer Institute, London, United Kingdom
     

Panel Discussion: Novel Concepts in Brain Cancer

6:15-7:15 p.m. | Grand Ballroom Salon HIJ

Session Chair: Stephen Bagley, University of Pennsylvania, Philadelphia, Pennsylvania

  • Panelists
    Mario L. Suvà, Harvard Medical School, Broad Institute of MIT and Harvard, Boston, Massachusetts
    Michelle Monje, Stanford Hospital, Stanford, California
    Simona Parrinello, University College London (UCL) Cancer Institute
    Frank Winkler, Heidelberg University, Heidelberg, Germany

POSTER SESSION A AND OPENING RECEPTION

7:15-9:15 p.m. |  Grand Ballroom Salon G

Tuesday, March 24

CONTINENTAL BREAKFAST

7-8 a.m. | Grand Ballroom Salon KL

Plenary Session 1: The Neuroscience of Gliomas  

8:30 a.m. | Grand Ballroom Salon HIJ

Session Chair: Michelle Monje, Stanford Hospital, Stanford, California

  • 8:35 a.m. | Neuronal activity drives glioma growth
    Michelle Monje 
  • 8:55 a.m. | Synaptic signaling drives tumor-mediated immune remodeling in glioma
    Benjamin Deneen, Baylor College of Medicine, Houston, Texas
  • 9:15 a.m. | Breaking the conversation: Therapeutics to interrupt tumor–neuron interactions
    Shawn Hervey-Jumper, University of California San Francisco, San Francisco, California

Break 

10-10:15 a.m. 

Plenary Session 2: Advances in NeuroImmunoOncology 

10:15-11:40 a.m. | Grand Ballroom Salon HIJ

Session Chair: Tyler E. Miller, Case Western Reserve University School of Medicine, Cleveland, Ohio

  • 10:20 a.m. | Redefining and targeting immunosuppressive myeloid cells in brain tumors
    Tyler E. Miller
  • 10:40 a.m. | Pediatric low-grade gliomas repurpose Neuron-OPC dependencies to control tumor growth
    David Gutmann, Washington University School of Medicine in St. Louis, St. Louis Missouri
  • 11 a.m. | Targeting tumor-associated peptide – major histocompatibility complexes in glioblastoma
    Lukas Bunse, DKFZ German Cancer Research Center, Heidelberg, Germany

Lunch on own

11:40 a.m.-1 p.m.

Plenary Session 3: Cellular Therapies for Nervous System Tumors 

1-2:30 p.m. | Grand Ballroom Salon HIJ

Session Chair: Stephen J. Bagley, University of Pennsylvania, Philadelphia, Pennsylvania

  • 1:05 p.m. | Interplay between infused and endogenous immune system: Implications for next-generation CAR-T engineering for GBM
    Donald M. O’Rourke, University of Pennsylvania, Philadelphia, Pennsylvania
  • 1:25 p.m. | Targeting the TGFβ Axis to improve CAR T cell therapy for glioblastoma
    Christine Brown, City of Hope National Medical Center, Durante, California
  • 1:45 p.m. | Cell state-directed CAR-T cell therapies for glioma
    Christopher Mount, Massachusetts General Hospital, Boston, Massachusetts

Break

2:30-2:45 p.m.

Plenary Session 4: Brain Borders and CNS Trafficking

2:45–4:15 p.m. | Grand Ballroom Salon HIJ

Session Chair: Jonathan Kipnis, Washington University School of Medicine in St. Louis, St. Louis, Missouri

  • 2:50 p.m. | Ungating barriers to the trafficking of tumor biomarkers and therapeutics in infiltrating CNS tumors
    Graeme F. Woodworth, University of Maryland, Baltimore, Maryland
  • 3:10 p.m. | Brain borders as a key neuroimmune interface
    Jonathan Kipnis
  • 3:30 p.m. | Lipid nanoparticles for overcoming biological barriers to mRNA delivery to the brain
    Michael John Mitchell, University of Pennsylvania, Philadelphia, Pennsylvania

Break

2:30-2:45 p.m.

Proffered Talks

4:30-6 p.m. | Grand Ballroom Salon HIJ

Session Chair: Stephen J. Bagley, University of Pennsylvania, Philadelphia, Pennsylvania

  • 4:30 p.m. | Closed-loop sonothermogenetic control of CAR T cells for precision imunotherapy of brain tumors
    Costas Arvanitis, Georgia Institute of Technology, Atlanta, Georgia
  • 4:40 p.m. | Microglia-derived extracellular vesicles in the crosstalk between glioblastoma and the periphery
    Irene Bertolini, The Wistar Institute, Philadelphia, Pennsylvania
  • 4:50 p.m. | GPNMB CAR-T cells target both glioblastoma and its immunosuppressive tumor microenvironment
    Sheila K. Singh, McMaster University, Hamilton, Ontario, Canada
  • 5 p.m. | Mechanisms of cognitive impairment in children treated for brain tumors
    Noor Al Dahhan, The Hospital for Sick Children, Toronto, ON, Canada
  • 5:10 p.m. | Telomere length heterogeneity shapes structural and amplification landscapes in IDH-mutant astrocytoma
    Maryam Jehangir, Translational Genomics Research Institute (TGen), Phoenix, Arizona
  • 5:20 p.m. | Interactome-seq: A novel technology for mapping neuron-cancer synapses at single-cell resolution
    Boxuan Zhao, University of Illinois Urbana Champaign, Urbana, Illinois
  • 5:30 p.m. | Investigating the effect of dopamine signaling on glioblastoma development
    Yaxu-Sofia Wang, The Hospital for Sick Children, Toronto, Ontario, Canada
  • 5:40 p.m. | Microglia restrain malignant transformation during glioblastoma initiation
    Keon Woo Kim, Korea Advanced Institute of Science and Technology, Daejon, Korea
  • 5:50 p.m. | Estrogen induces a pro-tumoral phenotype shift in microglia that contributes to E2-unresponsive breast cancer brain metastasis
    Karen L.F. Alvarez-Eraso, University of Colorado AMC, Aurora, Colorado

POSTER SESSION B AND OPENING RECEPTION

6-8 p.m. | Grand Ballroom Salon KL

Wednesday, March 25

CONTINENTAL BREAKFAST

7-8 a.m. | Grand Ballroom Salon KL

Plenary Session 5: Next Generation Diagnostics and Biomarkers 

8-9:30 a.m. | Grand Ballroom Salon HIJ

Session Chair: Craig Horbinski, The Mayo Clinic, Jackson, Florida

  • 8:05 a.m. | The present and future of methylation profiling in CNS tumors
    Craig Horbinski
  • 8:25 a.m. | Developing multi-analyte liquid biopsy approaches for neuro-oncology
    Chetan Bettegowda, Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 8:45 a.m. | Amino acid PET in patients with brain tumors
    Norbert Galldiks, University of Cologne, Cologne, Germany 

Break 

9:30-9:45 a.m. 

Plenary Session 6: Updates in Brain Metastases and Leptomeningeal Disease 

9:45-11:15 a.m. | Grand Ballroom Salon HIJ

Session Chair: Adrienne Boire, Memorial Sloan Kettering Cancer Center, New York, New York

  • 9:50 a.m. | Leptomeningeal metastasis interrupts metabolic homeostasis: Cognitive implications
    Adrienne Boire, Memorial Sloan Kettering Cancer Center, New York, New York
  • 10:10 a.m. | Neuronal dependencies of small cell lung cancer
    Humsa Venkatesh, Harvard Medical School/Brigham and Women’s Hospital, Boston, Massachusetts
  • 10:30 a.m. | Rewiring the CNS niche: GABA metabolic plasticity and blood–CSF barrier dynamics in brain metastasis
    Josh Neman, Keck School of Medicine, Los Angeles, California

Presentation of Appreciation Awards to the Conference Cochairs

11:25-11:30 a.m. | Grand Ballroom Salon HIJ

Presented by: Adrienne Boire, Memorial Sloan Kettering Cancer Center, New York City, New York

Break

11:30-11:45 a.m.

Plenary Session 7: Solving Tumor Heterogeneity: Spatial and 3D Genomics 

11:45 a.m.-1 p.m. | Grand Ballroom Salon HIJ

Session Chair: Mario Suva, Massachusetts General Hospital, Boston, Massachusetts

  • 11:50 a.m. | Single-cell and spatial genomic analysis of gliomas
    Mario Suva
  • 12:10 p.m. | Immortality and evolution, partners in the cancer crime
    Joseph F. Costello, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California
  • 12:30 p.m. | Shaping tumor cell plasticity and therapy resistance in glioblastoma
    Antonio Iavarone, University of Miami, Miami, Florida

Closing Remarks & Departure

1:15 p.m. | Grand Ballroom Salon HIJ

  • Mario Suva, Massachusetts General Hospital, Boston, Massachusetts