In This Section

Program

Please note that this meeting will take place as an in-person event in Toronto and will not live-stream content for virtual participation. The meeting content will be recorded and made available as an on-demand program after the conference.

All presentations are scheduled to be live, in-person presentations at the date and time specified below unless noted otherwise. Program in progress.

Thursday, July 15

FRIDAY, July 16

SATURDAY, July 17

SUNDAY, July 18

Thursday, July 15

Educational Session: What is “dormancy”?

6-7 p.m.

  • 6 p.m. | Quiescence and senescence as graded states of cell-cycle withdrawal
    Sabrina Spencer, University of Colorado, Boulder, Colorado
  • 6:30 p.m. | Christoph A. Klein, University of Regensburg, Regensburg, Germany

Keynote lecture 1

7-8 p.m.

  • 7:05 p.m | Joan Massagué, Memorial Sloan Kettering Cancer Center, New York, New York
Friday, July 16

Breakfast networking roundtables

7-9 a.m.

Keynote lecture 2

8-9 a.m.

  • 8:05 a.m. | Targeting dormant disseminated tumor cells to prevent lethal breast cancer recurrence
    Lewis Chodosh, University of Pennsylvania, Philadelphia, Pennsylvania

Plenary Session 1: Translating the concept of dormancy to the clinic

9-11 a.m.

  • 9 a.m. | Dorothy Sipkins, Duke University, Durham, North Carolina
  • 9:30 a.m. | Exploiting a novel window of opportunity to prevent brain metastases
    Manuel Valiente, Spanish National Oncological Research Center (CNIO), Madrid, Spain
  • 10 a.m. | Causal molecular drivers of breast cancer dormancy in bone
    Christine Chaffer, Garvan Institute of Medical Research, Sydney, Australia

Short talks selected from proffered abstracts

Lunch on own

12:30-2:30 p.m.

Plenary Session 2: Integrating persister cell biology into the dormancy paradigm

2:30-4:30 p.m.

  • 2:30 p.m. | Chris Marine, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium
  • 3 p.m. | Cathrin Brisken, Lausanne, Switzerland
  • 3:30 p.m. | James Alvarez, Fred Hutchinson Cancer Center, Seattle, Washington

Short talks selected from proffered abstracts

Break

4:30-4:50 p.m.

Plenary Session 3: Dormancy and Genetic Evolution

4:50-6:20 p.m.

  • 4:40 p.m. | Molecular recording for dissecting metastatic evolution
    Kamen Simeonov, Fred Hutchinson Cancer Center, Seattle, Washington
  • 5:20 p.m. | Evolutionarily distinct disseminated cancer cells cooperate to initiate metastasis
    Soledad Sosa, Albert Einstein School of Medicine, Bronx, New York

Short talks selected from proffered abstracts

poster session a

6:20-8:20 p.m.

Saturday, July 17

Breakfast Networking Roundtables

7-8 a.m.

Keynote Lecture 3

8-9 a.m.

  • 8:05 a.m. | Host physiology shapes the fate of the disseminated cancer cell
    Mikala Egeblad, Johns Hopkins University, Baltimore, Maryland

Plenary Session 4: Niche regulation of disseminated cancer cells

9-11 a.m.

  • 9 a.m. | Julio A. Aguirre-Ghiso, Albert Einstein College of Medicine, New York, New York
  • 9:30 a.m. | Tissue-specific immune regulation of metastatic cancer dormancy
    Ana Luisa Correia, Champalimaud Center for the Unknown, Lisbon, Portugal
  • 10 a.m. | Vascular control of metastasis
    Hellmut Augustin, German Cancer Research Center (DKFZ), Heidelberg, Germany

Short talks selected from proffered abstracts

Lunch on own

12:30-2:30 p.m.

Plenary Session 5: Immune interactions shape dormant populations

2:30-4 p.m.

  • 2:30 p.m. | Judith Agudo, Dana Farber Cancer Institute, Boston, Massachusetts
  • 3 p.m. | Making the invisible visible – unmasking early metastatic events
    Melanie Werner-Klein, University of Regensburg, Regensburg, Germany

Short talks selected from proffered abstracts

Poster Session B

4:15-6:15 p.m.

Sunday, July 18

Breakfast Networking Roundtables

7-8 a.m.

Keynote Lecture 4

8-9 a.m.

  • 8:05 a.m | John Dick, University of Toronto, Toronto, Ontario, Canada

Plenary Session 6: Metabolic regulation of disseminated cancer cell fate

9-10:30 a.m.

  • 9 a.m. | Adaptive mechanisms of breast cancer brain colonization
    Srinivas Malladi, Srinivas Malladi, UT Southwestern Medical Center, Dallas, Texas
  • 9:30 a.m. | EMT/plasticity-associated ferroptosis sensitivity and therapeutic options in cancer metastasis
    Thomas Brabletz, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Erlangen, Germany

Short talks selected from proffered abstracts

Break

10:30-10:50 a.m.

Plenary Session 7: Minimal residual disease detection, prediction of reactivation and interception

10:50 a.m.-12:20 p.m.

  • 10:50 a.m. | Genomic alterations in MRD cells of solid cancers
    Nikolas Stoecklein, Heinrich-Heine University Dusseldorf, Düsseldorf, Germany
  • 11:10 a.m. | Elucidating mechanisms of breast cancer tumor dormancy using human models
    Alana Welm, Huntsman Cancer Institute, Salt Lake City, Utah

Short talks selected from proffered abstracts

Closing remarks

12:20-12:30 p.m.