In This Section

Program

Please note that this meeting will take place as an in-person event in Albuquerque and will not live-stream content for virtual participation. The meeting content will be recorded and made available as an on-demand program after the conference.

All presentations are scheduled to be live, in-person presentations at the date and time specified below unless noted otherwise. Program in progress.

*-Short talk from proffered abstract

[R] – Remote Presentation

Thursday, December 4

Friday, December 5

Saturday, December 6

Thursday, December 4

REGISTRATION

3-7 p.m. | Pavillion Foyer

WELCOME AND OPENING Keynote

4-4:45 p.m. | Pavilion Ballroom 4-6

  • 4 p.m. | Keynote Lecture
    Cancer cachexia
    Eileen P. White, Rutgers University, New Brunswick, New Jersey

BREAK

4:45-5 p.m.

Plenary Session 1: Early Events and Clonal Origins

5-6:45 p.m. | Pavilion Ballroom 4-6

Session Chair: James V. DeGregori, University of Colorado, Anschutz Medical Campus, Colorado

  • 5 p.m. | The evolution of adaptive landscapes for somatic mutations to maximize animal fitness
    James V. DeGregori
  • 5:30 p.m. | Environmental oncogenomics: Investigating the impact of air pollution on lung cancer development
    Emilia Lim, University of British Columbia, British Columbia, Canada
  • 6 p.m. | Signals and mechanisms of lung cancer promotion by air pollutants
    William Hill, The Francis Crick Institute, London, United Kingdom
  • 6:30 p.m. | Goliath clades and in vivo tracking of clonal dynamics show three phases of UV-induced skin carcinogenesis*
    Kenneth Y. Tsai, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 

Opening Reception and Poster Session A

6:45-8:15 p.m. | Whyte and Chapel

Friday, December 5

CONTINENTAL BREAKFAST

7-8 a.m. | Pavilion Ballroom 1-3

Plenary Session 2: TRACING AND MODELING TUMOR eVOLUTION

Organized by the Cancer Evolution Working Group (CEWG) 

8-9:30 a.m. | Pavilion Ballroom 1-3

Session Chair: Laura M. Heiser, Oregon Health and Science University, Portland, Oregon 

  • 8 a.m. | Reconstructing evolution with Stochastically Emergent Tumors (SETs) reveals in vivo vulnerabilities
    Rohit Bose, University of California, San Francisco, California
  • 8:30 a.m. | Evolutionary cancer epidemiology
    Carlo C. Maley, Arizona State University, Tempe, Arizona
  • 9 a.m. | Spatiotemporal lineage tracing reveals the dynamics and plasticity of cancer evolution
    Dian Yang, Columbia University Irving Medical Center, New York, New York

COFFEE BREAK

9:30-10 a.m. | Pavilion Foyer

Plenary Session 3: Evolution Under Therapy: Resistance Mechanisms

10-11:45 a.m. | Pavilion Ballroom 4-6

Session Chair: Andrew J. Aguirre, Dana-Farber Cancer Institute, Boston, Massachusetts

  • 10 a.m. | Mechanisms of therapy resistance in pancreatic cancer
    Andrew J. Aguirre, Dana-Farber Cancer Institute, Boston, Massachusetts
  • 10:30 a.m. | Divergent evolution imparts tissue-specific metastatic proclivities and immunotherapy resistance
    Nathan E. Reticker-Flynn, Stanford University, Stanford, California
  • 11 a.m. | Susan M. Rosenberg, Baylor College of Medicine, Houston, Texas
  • 11:30 a.m. | Tumoroid model of mesenchymal ovarian cancers reproduce chemoresistance and EMT
    Kathleen Burkhardt, University of Michigan, Ann Arbor, Michigan

LUNCH ON OWN

11:45 a.m.-1:15 p.m.

Plenary Session 4: Metastasis: The Evolutionary Bottleneck

1:15-2:45 p.m. | Pavilion Ballroom 4-6

Session Chair: Mariam Jamal-Hanjani, University College London Cancer Institute, London, United Kingdom

  • 1:15 p.m. | Tracing metastasis evolution with hypermutable DNA 
    Kamila Naxerova, Harvard Medical School, Boston, Massachusetts
  • 1:45 p.m. | Evolution of lung cancer metastasis revealed through research autopsies in PEACE
    Mariam Jamal-Hanjani, University College London Cancer Institute, London, United Kingdom 
  • 2:15 p.m. | Examining the influence of the tumour microenvironment on metastasis in PEACE
    Sonya Hessey, University College London, London, United Kingdom
  • 2:30 p.m. | Longitudinal study of bone marrow adipocytes throughout tungsten-enhanced breast cancer metastasis*
    Charlotte M. McVeigh, University of New Mexico, Albuquerque, New Mexico

Lightning Lectures from Highly Rated Abstracts

2:45-3:15 p.m. | Pavilion Ballroom 4-6

Session Chair: Nathan E. Reticker-Flynn, Stanford University, Stanford, California

  • 2:45 p.m. | Introduction
    Nathan E. Reticker-Flynn 
  • 2:48 p.m. | Chromosomal rearrangements at the YAP/TAZ pathway genes are associated with heterogeneity and stem cell-like castration-resistant prostate cancer*
    Alexander Martinez-Fundichely, Weill Cornell Medicine, New York, New York 
  • 2:51 p.m. | Decoding the evolutionary landscape of soft tissue sarcomas: from multiregion origins to therapy-driven adaptation*
    Shaghayegh Soudi, Stanford Medicine, Stanford, California
  • 2:54 p.m. | Genetic evolution of immune escape across cancers*
    Wenjie Chen, The University of Texas MD Anderson Cancer Center, Houston, Texas
  • 2:57 p.m. | Temporally resolved proteomics identifies nidogen-2 as a co-target in pancreatic cancer that modulates fibrosis and therapy response*
    Brooke Pereira, Garvan Institute of Medical Research, Sydney, Australia
  • 3 p.m. | Metabolic rewiring and cellular crosstalk may drive grade transformation in pancreatic neuroendocrine tumors*
    Himanshu N. Singh, Memorial Sloan Kettering Cancer Center, New York, New York
  • 3:03 p.m. | Modeling karyotype-driven adaptations to metabolic restrictions predicts therapeutic response and immunogenicity in cancer*
    Vural Tagal, Moffitt Cancer Center, Tampa, Florida
  • 3:06 p.m. | Integrated genomic analysis defines early and late drivers of glioma evolution and survival outcome in GBM*
    Harpreet Kaur, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
  • 3:09 p.m. | Mapping clonal architecture and evolution in pediatric brain cancers*
    Minh A. Nguyen, University of Pennsylvania, Philadelphia, Pennsylvania

BREAK

3:15-3:30 p.m.

Plenary Session 5: Co-evolution of Tumor and Host Metabolism

3:30-5:15 p.m. | Pavilion Ballroom 4-6

Session Chair: Kenneth J. Pienta, Johns Hopkins University School of Medicine, Baltimore, Maryland

  • 3:30 p.m. | Massimo Loda, Weill Cornell Medicine, New York, New York
  • 4 p.m. | Can we find a clinically meaningful way to measure tumor metabolism? 
    Kenneth J. Pienta
  • 4:30 p.m. | Biomarker trajectories with tumor development and progression
    Samir M. Hanash, MD Anderson Cancer Center, Houston, Texas
  • 5 p.m. | NADPH-producing enzymes restrict precancer progression in the pancreas*
    Megan Radyk, University of Michigan, Ann Arbor, Michigan

BREAK

5:15-5:30p.m.

Plenary Session 6: The Tumor Microenvironment: A Driver of Evolution

5:30-7:15 p.m. | Pavilion Ballroom 4-6 

Session Chair: Mara H. Sherman, Memorial Sloan Kettering Cancer Center, New York, New York

  • 5:30 p.m. | Elana J. Fertig, University of Maryland School of Medicine, Baltimore, Maryland
  • 6 p.m. | Valerie M. Weaver, University of California San Francisco Medical Center, San Francisco, California
  • 6:30 p.m. | Deciphering cellular hierarchies in the pancreatic tumor microenvironment
    Mara H. Sherman
  • 7 p.m. | Multi-omic spatial analysis reveals reshaping of tumour-immune dynamics at the transition to invasive colorectal cancer*
    Ann-Marie Baker, Institute of Cancer Research, London, United Kingdom

Reception and Poster Session B

7:15-8:45 p.m. | Whyte and Chapel 

Saturday, December 6

CONTINENTAL BREAKFAST

7-8 a.m. | Pavilion Ballroom 1-3 

Plenary Session 7: Computational Approaches to Cancer Evolution

8-9:45 a.m. | Pavilion Ballroom 4-6 

Session Chair: Ben J. Raphael, Princeton University, Princeton, New Jersey

  • 8 a.m. | Reconstructing tumor evolution across space and time
    Ben Raphael
  • 8:30 a.m. | Niko Beerenwinkel, ETH Zurich, Basel, Switzerland
  • 9 a.m. | The evolutionary dynamics of cancer across species
    Chris Venditti, University of Reading, Reading, United Kingdom
  • 9:30 a.m. | Macroevolutionary genomics of cancer risk in birds and mammals
    George Butler, University College London (UCL) Cancer Institute, London, United Kingdom

coffee BREAK

9:45-10 a.m.

Plenary Session 8: Clinical Translation and Early Detection

10-11:45 p.m. | Pavilion Ballroom 4-6 

Session Chair: Marina Pasca di Magliano, University of Michigan Medical School, Ann Arbor, Michigan

  • 10 a.m. | Strategies to harness the immune effects of ionizing radiation
    Silvia C. Formenti, Weill Cornell Medicine, New York, New York
  • 10:30 a.m. | 3D genomic analysis of human pancreatic precancer 
    Laura D. Wood, Johns Hopkins University School of Medicine, Baltimore, Maryland 
  • 11 a.m. | Evolution of the pancreatic cancer microenvironment
    Marina Pasca di Magliano
  • 11:30 a.m. | Mathematical biomarkers enable personalized adaptive therapy based on outcome prediction in prostate cancer*
    Kit Gallagher, University of Oxford, Oxford, United Kingdom

Closing Remarks

11:45 a.m. | Pavilion Ballroom 4-6 

Mariam Jamal-Hanjani, University College London Cancer Institute, London, United Kingdom
Kenneth J. Pienta, Johns Hopkins University School of Medicine, Baltimore, Maryland
Mara H. Sherman, Memorial Sloan Kettering Cancer Center, New York, New York