In This Section

Program

Please note that this meeting will take place as an in-person event in Portland and will not live-stream content for virtual participation. The meeting content will be recorded and made available as an on-demand program after the conference. Please see the Registration page for details.

CME credit is available for in-person attendance for the designated sessions. On-demand presentations are not eligible for CME.

All presentations are scheduled to be live, in-person presentations at the date and time specified below unless noted otherwise. Program is subject to change.
[R] – remote presentation

Monday, November 14, 2022 

Tuesday, November 15, 2022 

WednesDAY, November 16, 2022 

thursDAY, November 17, 2022 

Monday, November 14, 2022 

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Welcome and opening Keynote lecture 
Session Chair: Sean J. Morrison, UT Southwestern Medical School, Dallas, Texas
6-7 p.m.  

Welcome from Cochairs
Fabrice André, Institut Gustave Roussy, Villejuif, France
Sean J. Morrison, UT Southwestern Medical School, Dallas, Texas
Danny R. Welch, University of Kansas Cancer Center, Kansas City, Kansas

Metastasis initiating cells and ecosystems 
Joan Massagué, Memorial Sloan Kettering Cancer Center, New York, New York 

Opening Reception 
7-8:30 p.m.  

Tuesday, November 15, 2022 

Continental Breakfast 
7-8 a.m.  
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Plenary Session 1: Metabolic Adaptations during Metastasis
Session Chair: Sean J. Morrison, UT Southwestern Medical School, Dallas, Texas 
8-10 a.m.  

Melanoma cells have layered and redundant mechanisms to protect them from oxidative stress during metastasis
Sean J. Morrison, UT Southwestern Medical School, Dallas, Texas

Title to be announced
Devon A. Lawson, UCI Health Chao Family Comp Cancer Center, Orange, California

Redox and BACH1 control of lung cancer metastasis
Martin O. Bergö, Karolinska Institutet, Stockholm, Sweden

Short talks selected from proffered abstracts

Break  
10-10:30 a.m.  
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Plenary Session 2: Epigenetic Plasticity and Metastasis
Session Chair: Danny R. Welch, University of Kansas Cancer Center, Kansas City, Kansas 
10:30 a.m.-12:30 p.m.  

Regulation of metastasis efficiency via mitochondrial genetics 
Danny R. Welch, University of Kansas Cancer Center, Kansas City, Kansas

Title to be announced
Christina Curtis, Stanford University, Stanford, California

Additional speakers to be announced

Short talks selected from proffered abstracts

Lunch Break (lunch on your own)
12:30-2:30 p.m.             
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Plenary Session 3: Circulating Cancer Cells and spatial diversity
Session Chair: Devon A. Lawson, UCI Health Chao Family Comp Cancer Center, Orange, California
2:30-4:30 p.m. 

Title to be announced
Catherine Alix-Panabières, Université de Montpellier, Montpellier, France

Biology and vulnerabilities of circulating tumor cell clusters [R]
Nicola Aceto, ETH Zurich, Zurich, Switzerland

Title to be announced
Daniel A. Haber, Massachusetts General Hospital, Boston, Massachusetts

Additional speakers to be announced

Short talks selected from proffered abstracts

Poster Session A (with light refreshments) 
4:30-6:30 p.m.

wednesday, november 16, 2022 

Continental Breakfast 
7-8 a.m.  
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Plenary Session 4: Genomic Changes in Metastatic Tumors
Session Chair: Fabrice André, INSERM U848 (Institut Gustave Roussy), Villejuif, France 
8-10 a.m.  

Genomic and epigenetic landscape of metastatic breast cancer 
Fabrice Andre, INSERM U848 (Institut Gustave Roussy), Villejuif, France 

Title to be announced
Samra Turajlic, The Francis Crick Institute, London, England

APOBEC mutation signature in cancer explained by the combined enzymatic action of APOBEC3B and APOBEC3A
Reuben Harris, UT Health San Antonio, San Antonio, Texas

Short talks selected from proffered abstracts

Break 
10-10:30 a.m.  
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Plenary Session 5: Routes of Metastasis
Session Chair: Melody A. Swartz, University of Chicago, Chicago, Illinois
10:30 a.m.-12:30 p.m.  

Effects of fluid shear stress on circulating tumor cells
Michael D. Henry, University of Iowa, Iowa City, Iowa

Title to be announced
Melody A. Swartz, University of Chicago, Chicago, Illinois 

Extracellular vesicles and particles promote metastatic organotropism and systemic disease 
David C. Lyden, Weill Cornell Medical College, New York, New York 

Short talks selected from proffered abstracts

Lunch Break (lunch on your own) 
12:30-2:15 p.m.
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Plenary Session 6: Microenvironment and Metastasis 
Session Chair: To be announced
2:15-4:45 p.m.  

Title to be announced
Ben Z. Stanger, Penn Medicine Abramson Cancer Center, Philadelphia, Pennsylvania

Endothelial – Tumor cell interactions during metastasis
Luisa Iruela-Arispe, Northwestern University Feinberg School of Medicine, Chicago, Illinois

Unique features and dependencies of brain metastases 
Michael A. Davies, UT MD Anderson Cancer Center, Houston, Texas 

Title to be announced
Rakesh K. Jain, Massachusetts General Hospital, Boston, Massachusetts

Short talks selected from proffered abstracts

Break 
4:45-5:15 p.m. 
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Keynote Session (In honor of Dr. Zena Werb) 
Session Chair: Danny R. Welch, University of Kansas Cancer Center, Kansas City, Kansas 
5:15-6:30 p.m. 

The dark web of cancer: How neutrophil extracellular traps orchestrate metastasis
Mikala Egeblad, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

Cell archetypes in human brain metastases: Connecting programs in tumor cells with the microenvironment
Hugo Gonzalez Velozo, University of California, San Francisco, California


Poster Session B (with light refreshments) 
6:30–8:30 p.m. 

thursday, november 17, 2022 

Continental Breakfast 
7-8 a.m.  
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Plenary Session 7: Dormancy and Overcoming Dormancy
Session Chair: Melanie G. Hayden Gephart, Stanford Hospital, Stanford, California
8-9:30 a.m.

Title to be announced
Melanie G. Hayden Gephart, Stanford Hospital, Stanford, California

Genetic evolution and phenotypic plasticity of disseminated cancer cells
Melanie Werner-Klein, University of Regensburg, Regensburg, Germany

Short talks selected from proffered abstracts

Break 
9:30-10:00 a.m.      
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Plenary Session 8: Signaling and Genetic Instability
Session Chair: to be announced
10:00-11:30 A.m.  

Title to be announced
George A. Calin, UT MD Anderson Cancer Center, Houston, Texas

Chromosomal instability as a driver of cancer metastasis 
Samuel F. Bakhoum, Memorial Sloan Kettering Cancer Center, New York, New York 

Short talks selected from proffered abstracts

Closing Remarks 
11:30-11:45 a.m. 

Fabrice André, Institut Gustave Roussy, Villejuif, France
Sean J. Morrison, UT Southwestern Medical School, Dallas, Texas 

*Short talk from proffered abstract