In This Section

Program

SUNDAY, JANUARY 9, 2022 

MONDAY, JANUARY 10, 2022 

TUESDAY, JANUARY 11, 2022 

WEDNESDAY, JANUARY 12, 2022 

SUNDAY, JANUARY 9, 2022 

Opening Plenary Session (Welcome, Keynote Talk) 
6-7 p.m.  

Metastasis initiating cells and ecosystems 
Joan Massagué, Memorial Sloan Kettering Cancer Center, New York, New York 

Opening Reception 
7-8:30 p.m.  

MONDAY, JANUARY 10, 2022 

Continental Breakfast 
7-8 a.m.  
Plenary Session 1: Metabolic Adaptations during Metastasis 
8-10 a.m.  

Title to be announced 
Sean J. Morrison, UT Southwestern Medical School, Dallas, Texas 

Metabolic rewiring potentiating metastasis formation 
Sarah-Maria Fendt, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium 

Redox and BACH1 control of lung cancer metastasis 
Martin O. Bergö, Karolinska Institutet, Stockholm, Sweden  

Two short-talks from highly-rated abstracts

Break  
10-10:30 a.m.  
Plenary Session 2: Epigenetic Plasticity and Metastasis 
10:30 a.m.-12:30 p.m.  

Regulation of metastasis efficiency via mitochondrial genetics 
Danny R. Welch, University of Kansas Cancer Center, Kansas City, Kansas 

Histone variants and chaperones in cancer 
Geneviève Almouzni, Institut Curie, Paris, France 

Squamous trans-differentiation in pancreatic cancer 
Christopher R. Vakoc, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 

Two short-talks from highly-rated abstracts

Lunch Break (lunch on your own)
12:30-2:30 p.m.             
Plenary Session 3: Circulating Cancer Cells
2:30-4:30 p.m. 

Title to be announced
Caroline Dive, CRUK Manchester Institute, Manchester, England

Biology and vulnerabilities of circulating tumor cell clusters
Nicola Aceto, University of Basel, Basel, Switzerland

CTCs as potentially vulnerable metastatic precursors
Daniel A. Haber, Massachusetts General Hospital, Charlestown, Massachusetts

Two short-talks from highly-rated abstracts

Poster Session A (with light refreshments) 
4:30-7 p.m.

TUESDAY, JANUARY 11, 2022 

Continental Breakfast 
7-8 a.m.  
Plenary Session 4: Genomic Changes in Metastatic Tumors 
8-10 a.m.  

Genomic and epigenetic landscape of metastatic breast cancer 
Fabrice Andre, INSERM U848 (Institut Gustave Roussy), Villejuif, France 

Clonal evolution of metastases 
Samra Turajlic, The Francis Crick Institute, London, England 

APOBEC mutagenesis in cancer metastasis 
Reuben Harris, University of Minnesota, Minneapolis, Minnesota 

Two short-talks from highly-rated abstracts

Break 
10-10:30 a.m.  
Plenary Session 5: Routes of Metastasis 
10:30 a.m.-12:30 p.m.  

Tumor metastasis to lymph nodes requires YAP-dependent metabolic reprogramming 
Goh Young Koh, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea 

Interplay between neutrophils and lymphangiogenesis in promoting metastasis 
Melody A. Swartz, University of Chicago, Chicago, Illinois 

Extracellular vesicles and particles promote organotropic metastasis and systemic disease 
David C. Lyden, Weill Cornell Medical College, New York, New York 

Two short-talks from highly-rated abstracts

Poster Session B (and lunch) 
12:30-3 p.m.  
Plenary Session 6: Microenvironment and Metastasis 
3-5 p.m.  

Title to be announced
Karin E. de Visser, Netherlands Cancer Institute, Amsterdam, Netherlands 

Heterogeneity and metastasis in breast cancer 
Kornelia Polyak, Dana-Farber Cancer Institute, Boston, Massachusetts 

Unique features and dependencies of brain metastases 
Michael A. Davies, UT MD Anderson Cancer Center, Houston, Texas 

Two short-talks from highly-rated abstracts

Keynote Session: 
*In honor of Dr. Zena Werb 
5:30 – 6:30 p.m. 

Title to be announced
Lisa M. Coussens, OHSU Knight Cancer Institute, Portland, Oregon

WEDNESDAY, JANUARY 12, 2022 

Continental Breakfast 
7-8 a.m.  
Plenary Session 7: Dormancy and Overcoming Dormancy 
8-10 a.m.  

Title to be announced
Mikala Egeblad, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 

The invisible phase of metastasis formation 
Christoph A. Klein, University of Regensburg, Regensburg, Germany 

Tracking cancer metastases using liquid biopsies 
Gerhardt Attard, UCL London Cancer Institute, London, England 

Two short-talks from highly-rated abstracts

Break 
10-10:30 a.m.      
Plenary Session 8: Signaling and Genetic Instability 
10:30 a.m.-12:30 p.m.  

The genomic evolution of melanoma from precursor lesions 
Boris C. Bastian, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California 

Chromosomal instability as a driver of cancer metastasis 
Samuel F. Bakhoum, Memorial Sloan Kettering Cancer Center, New York, New York 

Immune-mediated control of breast cancer metastatic outgrowth 
Alana L. Welm, University of Utah Huntsman Cancer Institute, Salt Lake City, Utah 

Two short-talks from highly-rated abstracts

Closing Remarks 
12:30-12:45 p.m.