Program
Please Note: All session times for the 12th AACR-JCA Joint Conference: Breakthroughs in Cancer Research – Translating Knowledge into Practice are U.S. Hawaii–Aleutian Daylight (HDT).
Saturday, December 10, 2022
Sunday, December 11, 2022
Plenary Session 1: Tumor Microenvironment
Plenary Session 2: Cancer Genomics and Cancer Evolution
Plenary Session 3: Cancer Immunology
Monday, december 12, 2022
Plenary Session 4: Cancer Immunotherapy
Plenary Session 5: Preclinical Models; Organoids; Genetic and Transplantation Models
Plenary Session 6: Epigenetics; Cancer Plasticity and Heterogeneity; RNA Networks
Tuesday, december 13, 2022
Plenary Session 7: Cancer Metabolomics
Plenary Session 8: Genome Instability
Plenary Session 9: Genetic and Environmental Factors in Carcinogenesis
Wednesday, december 14, 2022
Plenary Session 10: Early Detection of Cancer
Plenary Session 11: Drug Resistance
Plenary Session 12: New Technologies for Cancer Imaging and Other Emerging Technologies
Saturday, december 10, 2022
Opening Keynote session
6-7:30 p.m.
Reprogramming T Cells with CRISPR to enhance immunotherapy
Alexander Marson, University of California San Francisco, San Francisco, California
H. pylori infection, BRCAness, and gastric cancer
Masanori Hatakeyama, Institute of Microbial Chemistry, Tokyo, Japan
Opening Reception
7:30-9 p.m.
Sunday, december 11, 2022
Continental Breakfast and Networking Roundtables
7-8 a.m.
Plenary Session 1: Tumor Microenvironment
8-9:30 a.m.
The aging microenvironment and its impact on tumor progression
Ashani T. Weeraratna, Johns Hopkins University, Baltimore, Maryland
The role and mechanism of SASP in tumor microenvironment of obesity-associated liver cancer
Naoko Ohtani, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan
Mechanisms of neutrophil immune response in the bone metastatic prostate cancer
Leah M. Cook, University of Nebraska Medical Center, Omaha, Nebraska
Break
9:30-10 a.m.
Plenary Session 2: Cancer Genomics and Cancer Evolution
10 a.m.-12 p.m.
Extrachromosomal DNA (ecDNA): Cancer’s dynamic circular genome
Paul S. Mischel, Stanford University, Stanford, California
Genotype to phenotype mapping of tumorigenesis at single cell resolution
Christina Curtis, Stanford University, Stanford, California
Genetic basis of pediatric cancers
Junko Takita, Kyoto University, Graduate School of Medicine, Kyoto, Japan
Translating cancer evolutionary insights into clinical practice
Mariam Jamal Hanjani, University College London Cancer Institute, London, United Kingdom
Free Time
12-4:00 p.m.
Plenary Session 3: Cancer Immunology
4-5:30 p.m.
Regeneration of cytotoxic T lymphocytes from iPS cells: Development of “off-the-shelf T cells” for cell therapy targeting cancer and viral infection
Hiroshi Kawamoto, Kyoto University, Kyoto, Japan
Properties of tumor antigens determining induction of immunity
Nina Bhardwaj, The Tisch Cancer Institute, Icahn School of Medicine at Mt Sinai, New York, New York
Chimeric antigen receptors targeting of truncated O-glycopeptides
Avery D. Posey, Jr., University of Pennsylvania, Philadelphia, Pennsylvania
poster session A
5:30-7:30 p.m.
Monday, december 12, 2022
Continental Breakfast and Networking Roundtables
7-8 a.m.
Plenary Session 4: Cancer Immunotherapy
8-9:30 a.m.
When cancer cells enable an antitumor immune response
Antoni Ribas, UCLA Jonsson Comprehensive Cancer Center, Los Angeles, California
Immune suppression by regulatory T cells in the tumor microenvironment
Hiroyoshi Nishikawa, National Cancer Center, Tokyo, Japan
Clonal evolution in a tumor microenvironment
Yosuke Togashi, Chiba Cancer Center, Kashiwa, Japan
Break
9:30-10 a.m.
Plenary Session 5: Preclinical Models; Organoids; Genetic and Transplantation Models
10-11:30 a.m.
Modeling pancreatic cancer
David A. Tuveson, Cold Spring Harbor Laboratory Cancer Center; Lustgarten Foundation, Cold Spring Harbor, New York
Malignant subclone drives polyclonal metastasis of intestinal tumor-derived organoids
Masanobu Oshima, Kanazawa University, Kanazawa, Japan
Humanized mouse models for immuno-oncology studies
Anthony Rongvaux, Fred Hutchinson Cancer Center, Seattle, Washington
free time
11:30 a.m.-4 p.m.
Plenary Session 6: Epigenetics; Cancer Plasticity and Heterogeneity; RNA Networks
4-5:30 p.m.
Essential role of histone acetyltransferase TIP60 in acute myeloid leukemia
Issay Kitabayashi, National Cancer Center Research Institute, Tokyo, Japan
Chromatin structure dysregulated by aberrant splicing of BRD9 in cancer
Daichi Inoue, Institute of Biomedical Research and Innovation, Kobe, Japan
poster session b
5:30-7:30 p.m.
Tuesday, december 13, 2022
Continental Breakfast and Networking Roundtables
7-8 a.m.
PLENARY SESSION 7: CANCER METABOLOMICS
8-9:30 a.m.
Targeting cancer NAD dependence
Nobuhiro Tanuma, Miyagi Cancer Center, Miyagi, Japan
Cancer metabolism within the tumor microenvironments
Tsuyoshi Osawa, The University of Tokyo, Tokyo, Japan
Co-opting immune cells to support cancer progression through metabolic reprogramming
Susan M. Kaech, Salk Institute, La Jolla, California
break
9:30-10 a.m.
PLENARY SESSION 8: GENOMIC INSTABILITY
10-11 a.m.
The labile control of mitotic chromosome segregation underlies chromosomal instability in cancer cells
Toru Hirota, The Cancer Institute Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan
Maintenance of genome integrity by BRCA1 tumor suppressor
Natsuko Chiba, Tohoku University, Miyagi, Japan
free time
11 a.m.-4 p.m.
Plenary Session 9: Genetic and Environmental Factors in Carcinogenesis
4-5:30 p.m.
How ancestry leads to the DARC side of breast cancer disparities
Melissa B. Davis, Weill Cornell Medicine, New York, New York
Molecular assessment of pre-malignant lesions in gastric cancer
Patrick Tan, Duke-NUS Medical School, Singapore, Singapore
Comprehensive analyses of genome and DNA adducts elucidate association between environmental factors and human cancer development
Yukari Totsuka, National Cancer Center, Tokyo, Japan
Poster session c
5:30-7:30 p.m.
Wednesday, december 14, 2022
Continental Breakfast and Networking Roundtables
7-8 a.m.
Plenary Session 10: Early Detection of Cancer
8-9:30 a.m.
Fecal and tissue DNA for diagnosis and prognosis of colorectal cancer
John M. Carethers, University of Michigan, Ann Arbor, Michigan
Allele – environment interplay in Asian gastric cancer
Shumpei Ishikawa, The University of Tokyo, Tokyo, Japan
Exosomal proteins in cancer: Roles in cancer metastasis and biomarker potential
Ayuko Hoshino, Tokyo Institute of Technology, Tokyo, Japan
break
9:30-10 a.m.
Plenary Session 11: Drug Resistance and Preclinical Models in Cancer Research
10-11:30 a.m.
Mechanisms of resistance to systemic therapies in lung cancer
Katerina Politi, Yale Cancer Center, New Haven, Connecticut
Whole-animal approaches using Drosophila to develop novel therapeutic candidates for cancer treatment
Masahiro Sonoshita, Hokkaido University, Hokkaido, Japan
Models and strategies to study acral melanoma from Latin American patients
Patricia A. Possik, Brazilian National Cancer Institute, Rio de Janerio, Brazil
Free time
11:30 a.m.-4 p.m.
Plenary Session 12: New Technologies for Cancer Imaging and Other Emerging Technologies
4-5:30 p.m.
Visualizing immune responses using immunoPET
Anna M. Wu, City of Hope, Duarte, California
Title to be announced
Kenjiro Kimura, Osaka Metropolitan University, Osaka, Japan
Molecular imaging of receptor membrane dynamics to reverse drug resistance in cancer
Patricia Ribeiro Pereira, Washington University School of Medicine, St. Louis, Missouri