Program
- Plenary Sessions
- Major Symposia
- Advances in Diagnostics and Therapeutics
- Advances in Organ Site Research
- Advances in Population Sciences
- Advances in Prevention Research
- Advances in the Science of Cancer Health Disparities
- Awards and Lectures
- Forums
- Special Sessions
- Educational Sessions
- Methods Workshops
- Meet-The-Experts
Plenary Sessions
Saturday, April 9, 2022
Precancer Discovery Science
Chair: Catriona H.M. Jamieson, UCSD Moores Cancer Center, La Jolla, CA
- Avrum E. Spira, Johnson & Johnson and Boston University Medical Center, Boston, MA
- Rebecca Fitzgerald, Hutchison/MRC Research Center, Cambridge, United Kingdom
- Veronica Kinsler, The Francis Crick Institute, London, United Kingdom
- Susan M. Domchek, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
Sunday, April 10, 2022
Opening Plenary Session: Decoding Cancer Complexity, Integrating Science, Transforming
Patient Outcomes
Chair: Marcia R. Cruz-Correa, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR
- Michael R. Stratton, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
- Jason M. Crawford, Yale University, West Haven, CT
- Marcia C. Haigis, Harvard Medical School, Boston, MA
- Nickolas Papadopoulos, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
- Franziska Michor, Dana-Farber Cancer Institute, Boston, MA
- Charles L. Sawyers, Memorial Sloan Kettering Cancer Center, New York, NY
Monday, April 11, 2022
Decoding Cancer Health Disparities: Integration of Complex Data and Diversity to Achieve Equity
Chair: Mariana C. Stern, USC Norris Comprehensive Cancer Center, Los Angeles, CA
- Yu Shyr, Vanderbilt University Medical Center, Nashville, TN
- Matthew L. Meyerson, Dana-Farber Cancer Institute, Boston, MA
- Olusegun I. Alatise, Obafemi Awolowo University, Ile-Ife, Nigeria
- Andy Futreal, The University of Texas MD Anderson Cancer Center, Houston, TX
- Cheryl L. Willman, Mayo Clinic Comprehensive Cancer Center, Rochester, MN; and University of New Mexico Comprehensive Cancer Center, Albuquerque, NM
Tuesday, April 12, 2022
Precision Medicine for Immuno-Oncology and the Promise for the Future
Chair: Carl H. June, University of Pennsylvania, Philadelphia, PA
- Ton N. Schumacher, Netherlands Cancer Institute, Haarlem, The Netherlands
- Thomas F. Gajewski, University of Chicago, Chicago, IL
- Luis A. Diaz, Memorial Sloan Kettering Cancer Center, New York, NY
- Shannon J. Turley, Genentech, Inc., South San Francisco, CA
Wednesday, April 13, 2022
Tumor Evolution and Therapeutic Resistance
Chair: Anna D. Barker, Ellison Institute for Transformative Medicine, Los Angeles, CA
- Emmanuelle Passegué, Columbia University Irving Medical Center, New York, NY
- Peter J. Campbell, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
- Christine A. Iacobuzio-Donahue, Memorial Sloan Kettering Cancer Center, New York, NY
- Nicholas E. Navin, The University of Texas MD Anderson Cancer Center, Houston, TX
- Charles Swanton, The Francis Crick Institute, London, United Kingdom
AACR Annual Meeting 2022 Highlights: Vision for the Future
Chair: Marcia R. Cruz-Correa, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR
- Danny R. Welch, University of Kansas Cancer Center, Kansas City, KS
- Jennifer A. Doherty, University of Utah Huntsman Cancer Institute, Salt Lake City, UT
- Lillian L. Siu, UHN Princess Margaret Cancer Center, Toronto, ON, Canada
Major Symposia
- AACR-Bayard D. Clarkson Symposium on Cancer Stem Cell Metabolism, Proteostasis, and Metastasis
- Accelerated, Conditional, Provisional, or Temporary? A Comparison of International Expedited Approval Programs
- Adipose Tissue as a Driver of Carcinogenesis
- Aging and the Tumor Microenvironment’s Impact on Minimal Residual Disease and Cancer Recurrence
- Applications of Real-World Data: What Is the Role of Real-World data in Clinical Research and Practice?
- Artificial Intelligence in Cancer Research and Care
- Biomarkers of Cancer Evolution: From Bench to Clinical Application
- Bone Metastasis
- Cancer Drugs Repurposing for Rare Genetic Disorders: A Unique Opportunity for Patients
- Cancer Vaccines: New Developments and Clinical Response
- CAR T cells for Solid Tumors: Bullish or Bearish?
- Challenging Drug Targets
- Clinical Progress with CD3 Bispecifics
- Considerations and Concerns Among the Asian American and Pacific Islander (AAPI) Community
- Defining Clinical Benefit: Accelerated Approval in Precision Oncology
- Digital and Computational Histopathology: Taking Cancer Diagnostics to the Cutting Edge
- Dose Optimization for Antibody-Drug Conjugates
- Epigenetic Alterations as Cancer Therapeutic Targets
- Epigenome Biology and Cancer
- Extracellular Matrix Remodeling in Cancer
- Extrachromosomal DNA: Origins and Significance
- FDA OCE’s Educational Programs and Integration of Regulatory Science in Academia
- Genome Instability as a Driver of Cancer Evolution
- Germline Mutations as Drug Targets
- Highlighting the AACR/HBS/MMRF Summit: Reducing Disparities and Democratizing Cancer Care
- Identification of Pediatric Cancer Dependencies
- Immunoprevention and Clinical Trials
- KRAS Anniversary Session: Novel Mechanisms for Targeting KRAS
- Liquid Biopsy: From Discovery to Clinical Application
- Macroenvironmental and Microenvironmental Drivers of Cancer Stem Cell Generation
- Mechanisms of Cancer Stem Cell Immune Evasion
- Mechanisms of Structural Mutations in Cancer
- Metabolic and Nutritional Regulation of Cancer and Immunity
- Modern Synthetic Lethality Strategies in Targeting the DNA Damage Response and Beyond: Moving beyond PARP and BRCA
- Multiomics Approaches for Novel Oncopathogen Discovery and Related Mechanisms
- Myeloid Cell Control of Therapeutic Antitumor Immunity
- Nerves, Cancer, and Immunity
- Novel Genetic Screening Strategies to Identify Therapeutic Targets in Cancer
- Pediatric Oncology Drug Discovery and Development
- Physical Aspects of Cancer and Physical Sciences of Oncology
- Predictive Biomarkers for Precision Radiation Oncology
- Presidential Select Symposium: Aging, Stress, and Cancer
- Profiling Molecular Proximity in Cancer Research
- Radiation and Immunotherapy
- Role of the Metastatic Microenvironment
- Screening, Detecting, Intervening Earlier in Clinical Care of Underserved Populations
- Successful Development of Cancer Therapies for Ultra-Rare Indications
- Supporting Smoking Cessation Among Patients with Cancer Who Use Tobacco Products
- Targeted Protein Degradation: Exploring New Targets and E3 Ligases
- Tumor Dormancy
- Understanding Microbe-Tumor Interactions in Health and Disease: From Basic Mechanisms to Applied Microbial-Based Cancer Therapy
- Using Patient-Generated Data to Optimize the Dose for Oncology Drugs
Advances in Diagnostics and Therapeutics
- Adoptive Cellular Therapy: Treatment for the Masses
- Advances in Precision Diagnostics and Therapeutics
- Cancer Metabolic Phenotypes: A Precision Medicine Perspective for Radiation Oncology?
- Clinical to Genetic Monitoring for Hereditary Cancers
- Deep Learning for Cancer Imaging
- How Should Clonal Hematopoiesis Impact Cancer Treatment Decisions?
- Interpreting and Building Trust in Artificial Intelligence Models
- Machine Learning to Translate the Cancer Genome and Epigenome into Biological and Clinical Insights
- New Developments in Immunotherapy: Targeting and Localizing Cytokine Activity
- New Horizons in Neoadjuvant and Adjuvant Immunotherapy for Solid Tumors
- Next-Generation Costimulatory Receptor Agonists for Cancer Immunotherapy and Combination Therapy
- Peptide–Peptide Interaction Inhibitors in Cancer Therapeutics
- Targeting Transcription Factors
- Technologies to Understand Malignant Clonal Behavior at Single Cell Resolution
- Theranostics: The Interception of Detection and Treatment
Advances in Organ Site Research
- Advances in Bladder Cancer
- Advances in Glioblastoma Cancer Research and Cancer Care
- Advances in Neuroblastoma Research
- Advances in Ovarian Cancer Screening and Treatment
- Bone Marrow Immune Microenvironment
- Breast Cancer Genomics in Latin America
- Gastric Cancer: From Biology to Therapy
- Models for Rare Cancers
- Pediatric Tumors
- Progress in Understanding Nonalcoholic Fatty Liver Disease-Induced Liver Cancer and Associated Disparities
- The Next Generation of Targets for Prostate Cancer
- Triple Negative Breast Cancer: Molecular Insights and Treatment Advances
- Understanding Microbe-Tumor Relationships in Colorectal Cancer
Advances in Population Sciences
- Functional Role of Long Tail Coding and Non-coding Mutations in Cancer
- Impact of Off-Label Therapies in Cancer Care and Outcomes across Populations
- Where You Live Matters: From Biological to Social Determinants of Cancer Outcomes
Advances in Prevention Research
Advances in the Science of Cancer Health Disparities
- Applying an Equity Lens to Implementation Research: A Pathway to Reduce Cancer Health Disparities
- Molecular Epidemiology of Stress and Discrimination and Cancer Outcomes
- Obesity and Health Disparities in Cancer
Awards and Lectures
Forums
- Addressing Disparities in Cervical Cancer: A Tale of Two Strategies
- Advances in Lung Cancer
- Breaking Down Silos: If We Did It during the COVID Pandemic, Why Not for Cancer?
- How Have Genome-Wide Association Studies Impacted Cancer Research?
- Impact of Telehealth on Cancer Care Delivery
- Insights Into Choosing the Right Immune Oncology Drug Combinations for Patients
- Oligometastatic Disease
- Pancreas Cancer: Why Are We Moving So Slowly?
- Precision Oncology for Pediatric Cancer
- Untangling Mechanisms of Sensitivity and Resistance to Immune Checkpoint Blockade
- Vaccine Effectiveness in Cancer Patients with Immunotherapy
- What Is the Causal Link between Race and Early Onset of Colon Cancer?
Special Sessions
- AACR-ASCO Joint Session: Pathophysiology and New Treatments for Cancer-Associated Thrombosis
- AACR-JCA Joint Session on Organoids: Tumor Cells, Microenvironments, and Beyond
- Decoding Cancer Complexity and Transforming Patient Outcomes Using AACR Project GENIE
Educational Sessions
- Addressing Cancer Care Quality and Cancer Outcomes in Medicaid Populations
- Advances in Ligand Discovery Against Poorly Tractable Targets
- Advances in SHP2 Biology and Therapeutics for Targeting RAS-Driven Cancers
- Big Data Resources in Pediatric Cancer
- Cancer Dormancy and Immune Regulation
- Cancer Survivorship
- Cancer Target Validation Using Chemical Probes
- Chemistry to the Clinic, Part 1 of 3: Targeting Ras Beyond G12C
- Chemistry to the Clinic, Part 2 of 3: Progress in Small Molecule Cancer Immunology Therapy
- Combination Therapeutic Strategies in the Treatment of Lung Cancer
- Considerations of Tissue-Specific Aging in Cancer Research
- Defining Cancer Evolution Types and Their Impact on Cancer
- Degrading Undruggable Targets in Pediatric Cancer
- Developing Replicable Genomic Classifiers of Cancer
- Diet and Lifestyle Risks for Cancer
- Diet, Microbiota, and Cancer Immunotherapies
- Drug Resistance: Challenges and Prospects
- Examining Tissue Specific Stroma to Increase Therapeutic Opportunities in Metastasis
- Immunocytokines: Strategies for Drug Delivery and Tissue Targeting
- Implementation Science: Efforts to Improve Cancer Health Equity
- Increasing Diverse Participation in Biomedical Cancer Research: Best Practices and Innovation
- Introduction to AI/ML in Cancer Genomics and Imaging
- Metabolism, Inflammation, and Immunotherapy
- Minimal Residual Disease in Solid Tumors: What Does It Mean and How Should It Guide Treatment Decision-Making?
- Natural Killer (NK) Cells: From Cancer Orchestrators to Car-NK Therapy
- Neoadjuvant Immunotherapy: The Next Steps Towards Perfectionism and Personalization
- Novel Antibody Drug Conjugates
- Novel Strategies to Target the Cyclin-Dependent Kinases
- Organoids in Cancer Research
- Outreach and Education in COVID-19 Times: Opportunities and Lessons Learned
- Pathology for Cancer Researchers
- Polygenic Risk Scores: Considerations for Development and Evaluation
- Precision Cancer Prevention
- Predictive Biomarkers for Immunotherapy
- Radiotheranostics for Cancer
- Regenerative Response of Irradiated Tissues: Models and Signaling Pathways
- Roles of RNA in Cancer and Cancer Therapies
- Sex Matters: Understanding the Effect of Sex on Shaping the Tumor and Response to Cancer Therapy
- Single Cell Biology in Scale and Spatial Genomics
- Systems Biology Approaches to Cancer
- The Epigenetics of Cancer
- The Evolving Crosstalk in the Cancer Stem Cell Niche
- The Importance of Surgeon Engagement for Translational Cancer Research
- The Science Behind Cytokine Release Syndrome
- Tumor Immunology and Immunotherapy for Nonimmunologists: The Immunological Basis of Durable Responses to Cancer Immunotherapy
- Understanding Cell Death in Cancer Therapy
- Unfolding the Unfolded Protein Response (UPR) as a Diagnostic and Therapeutic Target in Cancer
Methods workshops
- Artificial Intelligence in Cancer Imaging
- Biobanks: Why You Need Them in Your Cancer Research Program
- Design and Analysis of Real-World Data for Cancer Research
- Engineering a new generation of nanomedicines
- From Molecular Glues to Interfacial Binders: Targeting Protein Complexes with Small Molecule Inhibitors
- Introduction to Network Biology and Knowledge Graphs in Cancer Research
- Liquid Biopsy: from biology to clinical use
- Methods and Implications for Using Race and Ancestry in Cancer Research
- Mitochondrial Dynamics
- New Concepts in Unraveling the 3D Genome
- Spatial Analysis on the Tumor Microenvironment
- Spatial Transcriptomics and Cellular Imaging analysis of the tumor microenvironment
- Using Real-world Clinico-genomic Data: AACR Project GENIE As A Use Case
Meet-the-expert
- #ResearchMatters: Tales from a Translational Physician Scientist Tackling Thoracic Tumors
- A Multilevel Outreach Framework to Increase Representation of African Americans and Latinx Populations in Genomic Research
- Advances in Science and Treatment of Myeloproliferative Neoplasms
- Base Excision Repair and Cancer
- Cancer Metabolism: Diet and Therapeutics
- Circulating Tumor DNA: Concepts, Challenges, and Future Opportunities
- Decoding Kidney Cancer
- Endometrial Cancer: Obesity and Disparities
- Epigenomics in Cancer Therapeutics
- Epithelial Stem Cells: How Memories of Stressful Experiences Fuel Cancer
- Evolutionary Therapy
- Exploring Latino Cancer Health Disparities with a Focus on Prevention and Community Intervention
- Glycans Tell Us About Function and Status: Applying this Information to the Detection and Treatment of Cancer
- History of Infections and Targets of Successful Immune Defense Inform Designs of Preventive Cancer Vaccines
- Human Natural Killer Cells: Basic Biology and Novel Clinical Applications for Cancer
- Immunogenomics of High-Grade CNS Malignancies
- Improving Treatment of Primary and Metastatic Brain Tumors: Emerging Strategies
- Integrating Evolutionary Dynamics into Treatment for Metastatic Cancer
- Lessons Learned Leading a Comprehensive Translational Program in Pancreatic Cancer: Precision Medicine One Patient at a Time
- Luminal B breast cancer genomics in Hispanic/Latinas: a window to tumor size and immune infiltration
- Mechanisms of Malignant Transformation of the Immune System and Precision Immunotherapy
- Next Generation Pathology: From Histopathology to Artificial Intelligence
- NGS Profiling
- Obesity, Diabetes, and Breast Cancer
- Patient-Derived Organoids: From Drug Development to Precision Oncology
- Predicting Outcomes in Neuroendocrine Tumors
- Proteogenomics as a driver for discovery of novel mechanisms and therapeutic targets in lymphoma
- Recent Developments in the Treatment of Soft Tissue Sarcomas and GIST: Biology Driven Drug Development
- Scalable Integrative Analysis of Large-Scale Biobanks, Whole Genome Sequencing Studies and Functional Multi-Omic Data
- Seeing Is Believing: Effective Data Visualization
- Targeting Clonal Heterogeneity in Treatment-refractory Brain Cancers with Rationally Designed Immunotherapies: Advances and Challenges
- The Current Status of Precision Medicine Trials in Cancer: Towards a Future Precision Medicine Strategy
- The Genomics of HPV Integration in Cancers
- The KEAP1-NRF2 System in Cancer Biology and Medicine
- The Melanoma Revolution and Lessons Learned From Basic Biology of Skin
- The Role of a Commonly Used Medication in the Prevention of Ovarian and Endometrial Cancers: A Spotlight on Statins
- Understanding and Targeting Aberrant RNA Splicing in Cancer
- Update on agonist CD40 antibodies for cancer immunotherapy