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Program

Thursday, June 25, 2020

Friday, June 26, 2020

Saturday, June 27, 2020

Sunday, June 28, 2020

Thursday, June 25, 2020

Plenary Session 1: Teaching T-Cells New Tricks – Why Immunotherapy Fails in Lymphoma and How Do We Fix It?
Moderator: Helen E. Heslop, Baylor College of Medicine, Houston, Texas
1:30-3:30 p.m.

Title to be announced
Karin Tarte, Université de Rennes, Rennes, France

Immune exhaustion and immune suppression in lymphoma
Stephen M. Ansell, Mayo Clinic College of Medicine, Rochester, Minnesota

Optimizing immunostimulatory antibodies for cancer immunotherapy
Mark Cragg, University of Southampton, Southampton, United Kingdom

Title to be announced
Christian Steidl, BC Cancer, Vancouver, BC, Canada

1 short talk from proffered abstract

Panel Discussion

Break
3:30-4 p.m.
Plenary Session 2: WHO vs. How? Changing Paradigms in Lymphoma Classification
Moderator: Anas Younes, Memorial Sloan Kettering Cancer Center, New York, New York
4-6 p.m.

Microenvironmental signatures reveal biological subtypes of DLBCL
Leandro C. Cerchietti, Weill Cornell Medical College, New York, New York

Title to be announced
Bjoern Chapuy, University of Göttingen, Göttingen, Germany

Molecular classification of T-cell lymphomas
Keisuke Kataoka, National Cancer Center, Japan, Tokyo, Japan

The role of gene expression in the classification of aggressive B-cell lymphoma
David W. Scott, BC Cancer, Vancouver, BC, Canada

1 short talk from proffered abstract

Panel Discussion

Break
6-6:15 p.m.
Opening Keynote Session
6:15-8 p.m.

Regulation of inflammation
David Artis, Weill Cornell Medicine, New York, New York

Rogue clones of self-reactive B cells with lymphoma driver mutations: A view of lymphoma precursors
Christopher Goodnow, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

Welcome Reception
8-10 p.m.

Friday, June 26, 2020

Continental Breakfast with Mentoring Roundtables
7-8 a.m.
Concurrent Sessions 1 & 2
8-9:15 a.m.
Concurrent Session 1: Towards a Better Understanding of Adolescent Young Adult Lymphoma
Moderator: Sonali M. Smith, University of Chicago, Chicago, Illinois

Title to be announced
Lisa G. Giulino-Roth, Weill Cornell Medical College, New York, New York

AYA lymphomas: Bridging the divide
Kara Kelly, Roswell Park Comprehensive Cancer Center, Buffalo, New York

Unique features of pediatric-type follicular lymphoma
Abner Louissaint, Massachusetts General Hospital, Boston, Massachusetts

Panel Discussion

Concurrent Session 2: How Aberrant Metabolism Fuels Lymphoma
Moderator: Francesco Bertoni, Institute of Oncology Research, Bellinzona, Switzerland

Folate metabolism in CNS lymphoma
Naama Kanarek, Boston Children’s Hospital, Boston, Massachusetts

Oncogenic Rag GTPase signaling links cellular nutrients with FL microenvironment
Alejo Efeyan, Spanish National Cancer Research Center (CNIO), Madrid, Spain

Metabolic control of lymphomagenesis
Andrew Michael Intlekofer, Memorial Sloan Kettering Cancer Center, New York, New York

Panel Discussion

Plenary Session 3: New CARs and Fine-Tuning Patient Selection for Therapy
Moderator: Carl H. June, University of Pennsylvania, Philadelphia, Pennsylvania
9:45-11:45 a.m.

CARs and armored CARs: Improving CAR T cell therapy for cancer
Renier J. Brentjens, Memorial Sloan Kettering Cancer Center, New York, New York

Title to be announced
Carl H. June, University of Pennsylvania, Philadelphia, Pennsylvania

CAR T-cells for T-cell lymphoma
Maksim Mamonkin, Baylor College of Medicine, Houston, Texas

Determinants of CAR-T outcomes: Host, tumor, and product
Sattva S. Neelapu, The University of Texas MD Anderson Cancer Center, Houston, Texas

1 short talk from proffered abstract

Panel Discussion

Lightning Round Poster Teaser Presentations
11:45 a.m.-12:15 p.m.
Free Time / Lunch on Own
12:15-2 p.m.
Plenary Session 4: Biology-Based Clinical Trials: A Myth or Hope for Reality?
Moderator: John F. Seymour, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
2-4 p.m.

Can we hope for success in biologically stratified DLBCL studies?
Andrew John Davies, University of Southampton School of Medicine, Southampton, United Kingdom

Translational genetics in follicular lymphoma: Towards risk-adapted and biology-guided therapies
Oliver Weigert, University Hospital, LMU Munich, Munich, Germany

Title to be announced
Steven M. Horwitz, Memorial Sloan Kettering Cancer Center, New York, New York

Precision treatment of lymphoma using genomics
Louis M. Staudt, National Cancer Institute, Bethesda, Maryland

1 short talk from proffered abstract

Panel Discussion

Break
4-4:15 p.m.
Special Session 1: Hot Topics in Pharma
4:15-5:45 p.m.
Poster Session A / Reception
6-8 p.m.

Saturday, June 27, 2020

Continental Breakfast with Mentoring Roundtables
7-8 a.m.
Concurrent Sessions 3 & 4
8-9:15 a.m.
Concurrent Session 3: Cancer Health Disparities in Lymphoma: How Do We Improve Outcomes?
Session Moderator: Christopher R. Flowers, The University of Texas MD Anderson Cancer Center, Houston, Texas

Risk disparities in lymphoid cancers: What we know and what we don’t
Wendy Cozen, USC Norris Comprehensive Cancer Center, Los Angeles, California

Cancer health disparities in lymphoma
Theresa H. M. Keegan, University of California Davis, Sacramento, California

Title to be announced
Christopher R. Flowers

Panel Discussion

Concurrent Session 4: Hitting Back at MYC / BCL2 Lymphomas
Moderator: David M. Weinstock, Dana-Farber Cancer Institute, Boston, Massachusetts

Mouse model systems of double-hit lymphomas
Dinis Calado, London Research Institute, London, United Kingdom

Targeting BCL-2 with Venetoclax
Jennifer R. Brown, Dana-Farber Cancer Institute, Boston, Massachusetts

Additional speaker to be announced

Panel Discussion

Break
9:15-9:30 a.m.
Plenary Session 5: Hacking the Lymphoma Epigenome to Create Better Therapies
Moderator: Ari M. Melnick, Weill Cornell Medical College, New York, New York
9:30-11:30 a.m.

The role of EZH2 gain-of-function mutations in lymphoma
Wendy Béguelin, Weill Cornell Medical College, New York, New York

Cooperative epigenetic interactions in normal and transformed germinal center B cells
Laura Pasqualucci, New York Presbyterian Hospital Herbert Irving Comprehensive Cancer Center, New York, New York

The epigenetic architecture of follicular lymphoma
Michael R. Green, The University of Texas MD Anderson Cancer Center, Houston, Texas

Title to be announced
Peter W.M. Johnson, University of Southampton, Southampton, United Kingdom

1 short talk from proffered abstract

Panel Discussion

Special Session 2: Topic to be announced
11:35 a.m.-12:45 p.m.
Free Time / Lunch on Own
12:45-2 p.m.
Plenary Session 6: Dissecting Lymphoma Cell by Cell – A Dynamic Tale
Moderator: Kojo Elenitoba-Johnson, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
2-4 p.m.

Resolving clonal variation and cellular tumor microenvironmental interactions in the B-cell lymphoma with single-cell genomics
Hanlee P. Ji, Stanford University, Stanford, California

Pathology from the atomic scale on up
Garry P. Nolan, Stanford Hospital, Stanford, California

Follicular lymphoma dynamics through single-cell analysis
Bertrand Nadel, Centre d’Immunologie de Marseille-Luminy, Marseille, France

Characterizing the tumor ecosystem in follicular lymphoma by CyTOF
Andrew P. Weng, BC Cancer, Vancouver, BC, Canada

1 short talk from proffered abstract

Panel Discussion

Break
4-4:30 p.m.
Plenary Session 7: Can We Find and Destroy Lymphoma Precursor Cells?
Moderator: Riccardo Dalla-Favera, Columbia University, New York, New York
4:30-6:00 p.m.

Tracking precursor stages of follicular lymphoma development
Sandrine Roulland, Centre d’Immunologie de Marseille-Luminy, Marseille, France

Defining lymphoma reservoirs: Clues from the genomics
Jessica Okosun, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom

Title to be announced
Zachary R. Hunter, Dana-Farber Cancer Institute, Boston, MA

Defining precursors in low-grade lymphomas that seed second lymphomas
David M. Weinstock, Dana-Farber Cancer Institute, Boston, Massachusetts

1 short talk from proffered abstract

Panel Discussion

Lightning Round Poster Teaser Presentations
6:05-6:35 p.m.
Poster Session B / Reception
6:45-8:45 p.m.

Sunday, June 28, 2020

Continental Breakfast
7-8 a.m.
Concurrent Sessions 5 & 6
8-9:15 a.m.
Concurrent Session 5: Preclinical Models – How to Best Predict Therapeutic Response
Moderator: Ricardo M. Attar, Janssen Research and Development, Wayne, Pennsylvania

Developing preclinical models for peripheral T-cell lymphomas
Teresa Palomero, Columbia University, New York, New York

Use of genetic and molecular profiling to predict therapeutic response in dogs with B-cell lymphoma
Luca Aresu, University of Turin, Turin, Italy

Title to be announced
Giorgio Inghirami, Weill Cornell Medicine, New York, New York

Title to be announced
Ankur Singh, Georgia Institute of Technology, Atlanta, Georgia

Panel Discussion

Concurrent Session 6: Understanding and Targeting Aberrant Receptor Signaling in Lymphoma
Moderator: Louis M. Staudt, National Cancer Institute, Bethesda, Maryland

MALT1 targeting in BCR-addicted lymphomas
Lorena Fontan, Weill Cornell Medical College, New York, New York

New insights into the mechanisms of lymphoma evasion from BCR dependence
Stefano Casola, The FIRC Institute of Molecular Oncology (IFOM), Milan, Italy

B-cell receptor–driven metabolism reprogramming
Benjamin Gewurz, Brigham & Women’s Hospital, Boston, Massachusetts

Panel Discussion

Break
9:15-9:30 a.m.
Plenary Session 8: Using Liquid Biopsies for Real-Time Monitoring of Lymphoma Biology and Clinical Decision-Making
Moderator: David W. Scott, BC Cancer, Vancouver, BC, Canada
9:30-11:30 a.m.

Approaches for personalized medicine in lymphoma through liquid biopsies
David M. Kurtz, Stanford University, Stanford, California

Detecting and quantifying mutations associated with treatment resistance in aggressive lymphomas using ctDNA
Ryan D. Morin, Simon Fraser University, Burnaby, BC, Canada

Qualification and quantification of lymphoma under therapy by ctDNA analysis
Davide Rossi, Institute of Oncology Research, Bellinzona, Switzerland

ctDNA in indolent lymphoid cancers treated with targeted therapies
Constantine S. Tam, St. Vincent’s Hospital Sydney, East Melbourne, Australia

1 short talk from proffered abstract

Panel Discussion

Closing Keynote Lecture / Closing Remarks
11:30 a.m.-12:30 p.m.

Cellular and molecular control of germinal center B cell selection
Gabriel Victora, The Rockefeller University, New York, New York