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FINDING CURES TOGETHER<sup>SM</sup>

Obesity and Cancer: Mechanisms Underlying Etiology and Outcomes

​Program

Saturday, Jan. 27​

Welcome
5:30-5:45 p.m.

Welcome Remarks
Conference Cochairs


Plenary Session 1: Global Obesity Burden​
Session Chair: Elizabeth A. Platz, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
5:45-7 p.m.

Interpreting literature evidence on obesity and cancer
Konstantinos K. Tsilidis, University of Ioannina School of Medicine, Ioannina, Greece

Global burden of cancer attributable to excess body weight
Andrew Renehan, University of Manchester, Manchester, United Kingdom

Estimating the current and future cancer burden attributable to obesity in Canada*
Darren Brenner, University of Calgary, Calgary, AB, Canada


Opening Reception
7-9 p.m.


Sunday, Jan. 28

Continental Breakfast

7-8 a.m.


Plenary Session 2​:
Insulin and Glycemia: Roles in Obesity and Cancer
Session Chair: Michael N. Pollak, McGill University, Montreal, QC, Canada
8-9:45 a.m.

Mechanisms of lipid-induced insulin resistance: Implications for obesity and cancer
Gerald Shulman, Yale University, New Caven, Connecticut

Insulin responsivity of cancer subsets
Michael N. Pollak

Obesity, hyperglycemia, and cancer in black and white adults
Corinne E. Joshu, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland

Circumventing insulin feedback increases PI3K inhibitor efficacy*
Benjamin Hopkins, Weill Cornell Medicine, New York, New York  


Break
9:45-10:15 a.m.


Plenary Session 3: Inflammation as a Consequence of Obesity
Session Chair: Andrew J. Dannenberg, Weill Medical College of Cornell University, New York, New York
10:15-12:00 p.m.

Breast adipose inflammation: A silent killer
Andrew J. Dannenberg

Understanding the differential role of white and brown adipocytes in cancer: depicting the mechanisms linkingobesity and cancer
Kelly Grace Magalhaes, Univeristy of Brasília, Brasília, Brazil

Metformin decreases obesity-associated macrophage infiltration and lymphangiogenesis in the tumor microenvironment in a rodent model of breast cancer*
Erin Giles, Texas A&M University, College Station, Texas 

Reversing the procancer effects of obesity in a mouse model of colon cancer: Diet versus drug*
Laura Bowers, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Obesity and breast cancer metastasis: The role of inflammation*
Shannon McDonell, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina


Poster Session A/Lunch
12:00-2:15 p.m.


Plenary Session 4: Site-Specific Cancers part 1
Session Chair: Lorelei Mucci, Harvard T.H. Chan School of Public Health, Boston, Massachusetts
2:15-4:15 p.m.

Intersection of diet and whole body metabolism on tumor progression
Matthew G. Vander Heiden, David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts

Exploring mechanisms underlying the link between obesity and lethal prostate cancer
Lorelei Mucci

Body weight and weight change over the life course and subsequent risk of breast cancer
Susan E. Hankinson, University of Massachusetts Amherst, Amherst, Massachusetts

​​Body fat and risk of breast cancer in normal-size postmenopausal women*
Neil Iyengar, Memorial Sloan Kettering Cancer Center, New York, New York

Obesity and metabolic syndrome correlate with poor oncologic outcome in prostate cancer patients who underwent radical prostatectomy*
 Arash Samiei, Allegheny Health Network, Department of Urology, Pittsburgh, Pennsylvania


​Break
4:15-4:45 p.m.​


Plenary Session 5: Metabolomics and Cancer Risk
Session Chair: Ralph J. DeBerardinis, University of Texas Southwestern Medical Center, Dallas, Texas
4:45-6:00 p.m.

A metabolomics analysis of body mass index and postmenopausal breast cancer risk
Steven C. Moore, National Cancer Institute, Bethesda, Maryland

Subtype-selective metabolic phenotypes in cancer
Ralph J. Deberardinis​

​​Redox-active metabolites predict clinically relevant nonalcoholic fatty liver disease in the Multiethnic Cohort-Adiposity Phenotype Study (MEC-APS)*
Bruce Kristal, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts


Dinner on Own
6:00 p.m.  


​​Monday, Jan. 29

Continental Breakfast 
7-8 a.m.


Plenary Sesion 6: Site-Specific Cancers part 2
Session Chair: Anna Mae Diehl, Duke University, Durham, North Carolina
8-10 a.m. 

Obesity and liver cancer: From metabolic alterations to adaptive immunity
Michael Karin, University of California San Diego, San Diego, California

Primary liver cancer and NAFLD
Anna Mae Diehl

​Abdominal versus gluteofemoral obesity and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project*
Jessica Petrick, National Cancer Institute, Bethesda, Maryland

Adipokines, visfatin and resistin, promote an invasive liver cancer phenotype* 
Candance Miethe, Texas State University, San Marcos, Texas 

Exploring mechanisms of obesity-driven pancreatic cancer progression in mice*
Mandar Muzumdar, Yale University School of Medicine, New Haven, Connecticut​


Break
10-10:45 a.m.


Plenary Session 7: Spotlight on Circadian Rhythms in the Development of Obesity
10:45-11:30 a.m.

Circadian disruption, insulin resistance, and c​ancer
Neil E. Caporaso, National Cancer Institute, Bethesda, Maryland

Sleep duration and circadian components of the sleep/wake cycle and their association with body mass index and eating behaviors in children*
Bernard Fuemmeler, Virginia Commonwealth University, Richmond, Virginia


Lunch on Own​
11:30 a.m.-2 p.m. 


Plenary Session 8: Spotlight on the Microbiome in Obesity and Cancer
Rachel Jamison Perry, Yale Medical School, New Haven, Connecticut
2-3:30 p.m.

Uncoupling hepatic oxidative phosphorylation reduces tumor growth in a murine colon cancer model
Rachel Jamison Perry

The microbiome and obesity control the tumor microenvironment in the liver and control anti-tumor immunity
Tim F. Greten, National Cancer Institute, Bethesda, Maryland

Nonalcoholic fatty liver disease (NAFLD), an important risk factor for liver cancer, and links to the microbiome in the Multiethnic Cohort-Adiposity Phenotype Study (MEC-APS)* Meredith Hullar, Fred Hutchinson Cancer Research Center, Seattle, Washington 

Shifts in gut microbiome populations induced by diet modulate obesity-mediated breast cancer risk*
Katherine Cook, Wake Forest University Health Science, Winston Salem, North Carolina


Break
3:30-4 p.m.


Keynote Speaker
4-5 p.m.

Leptin and the Pathogenesis of Obesity : Studies of the Neural Circuit Controlling Food Intake and Body Weight
Jeffrey M. Friedman, The Rockefeller University, New York, New York


Poster Session B
5-7:30 p.m.

Tuesday, January 30

Continental Breakfast

7-8 a.m.


Plenary Session 9: Interventions for Patients Under Study
Lewis C. Cantley, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York
8-9:45 a.m.

PI 3-Kinase links obesity, insulin resistance, and cancer
Lewis C. Cantley

Title to be announced
Kathryn H. Schmitz, Penn State Cancer Institute, Hershey, Pennsylvania

Promoting weight loss in the presurgical setting: What happens to the tumor and the host?
Wendy Demark-Wahnefried, University of Alabama Comprehensive Cancer Center, Birmingham, Alabama

Effects of aerobic and resistance exercise on sarcopenic obesity in overweight or obese breast cancer survivors: A randomized controlled trial*
Christina Dieli-Conwright, University of Southern California, Los Angeles, California


Break
9:45-10:15 a.m.​


Panel Discussion: Prevention of Obesity-Related Cancer at Population Level
Facilitator: Elizabeth A. Platz, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
10:15 a.m.-12 p.m.

Graham A. Colditz, Washington University in St. Louis, St. Louis, Missouri

Gary Taubes, Nutrition Science Initiative, Oakland, California​

Stephen D. Hursting, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

Bruce Y. Lee, Johns Hopkins School of Public Health, Baltimore, Maryland 

​Elizabeth A. Platz​

Closing Remarks
12 p.m.

​​*Short talk from proffered abstract