June 19 - 22, 2018
Hyatt Regency Montreal
Montreal, QC, Canada
Abstract submission deadline: Monday, March 12
Advance registration deadline: Thursday, May 3
Tuesday, June 19
Wednesday, June 20
Tuesday, June 19
Welcome and Opening Keynotes5-7 p.m.
The cancer dormancy paradigm and how it transformed metastasis researchJulio A. Aguirre-Ghiso, Icahn School of Medicine at Mount Sinai, New York, New York
The grand challenge: How to distinguish normal from dormant breast cancer cells?
Mina Bissell, Lawrence Berkley National Laboratory, Berkley, California
Welcome Reception7-9 p.m.
Wednesday, June 20
Plenary Session 1: The Role of DTC Heterogeneity in Early Systemic Cancer, Distant Site Adaptation and SelectionSession Chairs: Julio A. Aguirre-Ghiso, Icahn School of Medicine at Mount Sinai, New York, New York, and Rachelle Johnson, Vanderbilt University Medical Center, Nashville, Tennessee8-10:15 a.m.
Genomic profiling of minimal residual cancer cellsNikolas Stoecklein, University of Düsseldorf, Düsseldorf, Germany
Evolution of lethal metastatic cancer at primary and metastatic sites: Can we identify what is important? G. Steven Bova, University of Tampere, Tampere, Finland
Clonal dynamics during tumor regression, residual disease, and recurrence*James Alvarez, Duke University School of Medicine, Durham, North Carolina
The earliest precursor cell of melanoma metastasis: Identification and molecular characterization of candidate metastasis founders* Courtney König, University of Regensburg, Regensburg, Germany
NR2F1 limits dissemination and stem-like features of early cancer mammary epithelial cells*M. Soledad Sosa, Icahn School of Medicine at Mount Sinai, New York, New York
Plenary Session 2:
Pro-dormancy NichesSession Chairs: Cyrus M. Ghajar, Fred Hutchinson Cancer Research Center, Seattle, Washington, and M. Soledad Sosa, Icahn School of Medicine at Mount Sinai, New York, New York10:30 a.m.-1:00 p.m.
The perivascular niche protects disseminated tumor cells from therapyCyrus M. Ghajar
Elucidating the bone marrow niches of dormant, treatment-resistant leukemic cells and disseminated breast cancer cellsDorothy A. Sipkins, Duke University, Durham, North Carolina
Stem cell pathways in dormancy and reactivationFilippo Giancotti, MD Anderson Cancer Center, Houston, Texas
Melanoma dormancy and the aged tumor microenvironment: WNT5A drives disseminated melanoma cell dormancy*Mitchell E. Fane, Wistar Institute, Philadelphia, Pennsylvania
Inhibiting metastatic outgrowth of dormant tumor cells using soluble mediators of resolution-promoting macrophages*
Dalit Barkan, University of Haifa, Haifa, Israel
Lunch on Own1:00-3:00 p.m.
Plenary Session 3:
Metastatic NichesSession Chairs: Rosandra Kaplan, National Cancer Institute, Bethesda, Maryland, and Dalit Barkan, University of Haifa, Haifa, Israel3:00-5:30 p.m.
New protagonists of the tumor microenvironmentIlaria Malanchi, The Francis Crick Institute, London, United Kingdom
Microenvironmental control of bone metastasis in breast cancerAlana Welm, Huntsman Cancer Institute, Salt Lake City, Utah
Claudin-2 is a mediator of breast and colorectal cancer metastasisPeter Siegel, McGill University, Montreal, QC, Canada
The role of stromal cell plasticity in the dormant to proliferative switch of disseminated cancer cellsRosandra Kaplan
NRP2-SEMA3s-PLXNs axis regulates the dormancy state of disseminated tumor cells and metastasis progression in breast and head and neck cancer*Leire Recalde-Percaz, University of Barcelona, Barcelona, Catalonia, Spain
Glioma cells with downregulated IGF-IR expression can persist in the brain in a dormant state*
Pnina Brodt, Research Institute of the McGill University Health Center, Montreal, QC, Canada
Poster Session A/Reception5:30-7:30 p.m.
Thursday, June 21
Keynote Presentation8-9 a.m.
Mechanisms of HIV reservoir maintenanceDaniel Douek, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland
Plenary Session 4: Reservoirs of Disease: Parallels between Cancer, HIV and Tuberculosis
Session Chairs: Daniel Douek, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, and Darren Carpizo, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Title to be announcedRafick-Pierre Sékaly, Case Western Reserve University, Cleveland, Ohio
Targeting the one in a million: detection and elimination of the HIV latent reservoir
Ya-Chi Ho, Yale School of Medicine, New Haven, Connecticut
In vivo gene editing of latent herpes simplex virus and HIV: Lessons from direct attacks on viral reservoirsKeith Jerome, Fred Hutchinson Cancer Research Center, Seattle, Washington
Plenary Session 5:
Protective Niches for Stem Cells in Adult TissuesSession Chairs: Dorothy A. Sipkins, Duke University, Durham, North Carolina, and Paloma Bragado, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain11:00 a.m.-12:45 p.m.
Dormancy in Normal and Malignant Stem CellsAndreas Trumpp, Heidelberg Institute for Stem Cell Technology and Regenerative Medicine, Heidelberg, Germany
Pathways regulating tumor dormancy by the hematopoietic stem cell nicheRussell Taichman, University of Michigan, Ann Arbor, Michigan
scRNAseq approaches to define gene signatures that may control dormancy in myelomaPeter Croucher, Garvan Institute of Medical Research, Sydney, Australia
Visualizing tumor dormancy in mouse models of cancer*
Joshua C. Snyder, Duke University School of Medicine, Durham, NC
Poster Session B/Lunch12:45-3:30 p.m.
Plenary Session 6:
Technologies to Image and Profile Disseminated Tumor CellsSession Chairs: Jason Bielas, Fred Hutchinson Cancer Research Center, Seattle, Washington, and Courtney König, University of Regensburg, Regensburg, Germany3:30-5:30 p.m.
High resolution multiphoton imaging of the mechanism of how breast and pancreatic adenocarcinoma initiate and sustain systemic disseminationJohn Condeelis, Albert Einstein College of Medicine, Bronx, New York
Evening off5:30 p.m.
Plenary Session 7: Dormancy and Immune EvasionSession Chairs: Daniela F. Quail, McGill University Goodman Cancer Center, Montreal, QC, Canada, and Frank Cackowski, University of Michigan, Ann Arbor, Michigan8-10:15 a.m.
Neutrophil extracellular traps produced during inflammation awaken dormant cancer cellsMikala Egeblad, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
The MYC oncogene regulates the immune response influencing tumor initiation, progression and dormancyDean W. Felsher, Stanford University, Stanford, Stanford, California
Targeting macrophages in the brain tumor microenvironmentDaniela F. Quail
NK cells govern breast cancer latency in the liver* Ana Luisa Correia, University of Basel/University Hospital Basel, Basel, Switzerland
Estrogen promotes immune evasion in the liver to enhance metastatic expansion* Simon Milette, McGill University, Montreal, QC, Canada
The role of the tumor microenvironment in breast cancer dormancy*
Andrea Walens, Duke University, Durham, North Carolina
Plenary Session 8:
Translating Dormancy to the ClinicSession Chairs: Christoph A. Klein, University of Regensburg, Regensburg, Germany, and Simon Milette, McGill University, Montreal, QC, Canada10:30 a.m.-12:30 p.m.
Tumor dormancy in the clinic: The curious case of late relapseKathy D. Miller, Indiana University School of Medicine, Indianapolis, Indiana
Clinical potential of targeting leukemic stem cells to reduce the burden of minimal residual diseaseRavi Bhatia, University of Alabama, Birmingham, Alabama
Development of a clinical trial to induce therapeutic dormancy in prostate cancer
William Oh, Icahn School of Medicine at Mount Sinai, New York, New York
Investigating Dec2 as a biomarker of human dormant metastatic tumor cells in colorectal cancer*
Darren Carpizo, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey
Selective inhibition of the stress kinase PERK blocks HER2-driven tumorigenesis and suppresses metastasis by targeting quiescent disseminated tumor cells*
Veronica Calvo, Icahn School of Medicine at Mount Sinai, New York, New York
Closing Remarks12:30 p.m.
*Short talks from proffered abstracts