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FINDING CURES TOGETHER<sup>SM</sup>

Cancer Dormancy and Residual Disease

​Program

Tuesday, June 19, 2018​

Welcome and Opening Keynotes
5-7 p.m.

Title to be announced
Julio A. Aguirre-Ghiso, Icahn School of Medicine at Mount Sinai, New York, New York

Microenvironmental cancer control
Mina Bissell, Lawrence Berkley National Laboratory, Berkley, California


Welcome Reception

7-9 p.m.​​


Wednesday, June 20, 2018

Plenary Session 1: Setting the Stage: Translating Dormancy to the Clinic
8-10:15 a.m.

Late relapse, the clinical face of tumour dormancy
Kathy D. Miller, Indiana University School of Medicine, Indianapolis, Indiana

Title to be announced
Ravi Bhatia, University of Alabama, Birmingham, Alabama

Additional speaker to be announced

Short talks from proffered abstracts​

Break

10:15-11:30 a.m.


Plenary Session 2: Pro-dormancy Niches

10:45 a.m.-1:30 p.m.

The perivascular niche protects disseminated tumor cells from therapy
Cyrus M. Ghajar, Fred Hutchinson Cancer Research Center, Seattle, Washington

Title to be announced
Dorothy A. Sipkins, Duke University, Durham, North Carolina

​Title to be announced
Filippo Giancotti, MD Anderson Cancer Center, Houston, Texas

Regulation of Tumor Dormancy by Hypoxia
Amato Giaccia, Stanford University, Stanford, California

Short talks from proffered abstracts​


Lunch on Own
1:30-3:30 p.m.​​​​​​​


Plenary Session 3:
Metastatic Niches
3:30-5:30 p.m.

The teamwork of neutrophils and cancer
Ilaria Malanchi, The Francis Crick Institute, London, United Kingdom

Microenvironmental control of bone metastasis in breast cancer
Alana Welm, Huntsman Cancer Institute, Salt Lake City, Utah

Title to be announced
​​Peter Siegel, McGill University, Montreal, QC, Canada

The role of stromal cell plasticity in the dormant to proliferative switch of disseminated cancer cells
Rosandra Kaplan, National Cancer Institute, Bethesda, Maryland 

Short talks from proffered abstracts

​​
Poster Session A/Reception

5:30-7:30​ p.m.


Thursday, June 21, 2018​

​Keynote Presentation
8-9 a.m.

Mechanisms of HIV reservoir maintenance
Daniel Douek, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

Plenary Session 4: Reservoirs of Disease: Parallels between Cancer, HIV and Tuberculosis
9-11 a.m.

Title to be announced​
Rafick-Pierre Sékaly, Case Western Reserve University, Cleveland, Ohio

HIV Cure: Going b​eyond N=1
Robert F. Siliciano, Johns Hopkins University School of Medicine, Baltimore, Maryland

Title to be announced
Keith Jerome, Fred Hutchinson Cancer Research Center, Seattle, Washington

Short talks from proffered abstracts
​​

Break
11-11:30 a.m.


Plenary Session 5:
Dormancy and Immune Evasion
11:30 a.m.-1:30 p.m.

Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells
Mikala Egeblad, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

The MYC Oncogene is a Global Regulator of the Immune Response
Dean W. Felsher, Stanford University, Stanford, Stanford, California

Microenvironmental regulation of tumor suppression and activation.
Daniela F. Quail, McGill University Goodman Cancer Center, Montreal, QC, Canada​

​Short talks from proffered abstracts


Poster Session B/Lunch
1:30-3:30 p.m.​


Plenary Session 6: Technologies to Image and Profile Disseminated Tumor Cells
3:30-5:30 p.m.         

Title to be announced
John Condeelis, Albert Einstein College of Medicine, Bronx, New York

Intravital microscopy revealed cancer cell plasticity to be important for metastasis
Jacco van Rheenen, Hubrecht Institute, Utrecht, The Netherlands

Title to be announced
​Jason Bielas, Fred Hutchinson Cancer Research Center, Seattle, WA

Short talks from proffered abstracts


Evening off
5:30 p.m.​​​

​​​​
Friday, June 22, 2018​

​Plenary Session 7Protective Niches for Stem Cells in Adult Tissues
8-10 a.m.

​Dormancy in Normal and Malignant Stem Cells
Andreas Trumpp, Heidelberg Institute for Stem Cell Technology and Regenerative Medicine, Heidelberg, Germany

Pathways regulating tumor dormancy by the hematopoietic stem cell niche
Russell Taichman, University of Michigan, Ann Arbor, Michigan

scRNAseq approaches to define gene signatures that may control dormancy in myeloma
Peter Croucher, Garvan Institute of Medical Research, Sydney, Australia

Short talks from proffered abstracts


Break
10-10:30 a.m.

Plenary Session 8: The Role of DTC Heterogeneity in Early Systemic Cancer, Distant Site Adaptation and Selection
10:30 a.m.-12:30 p.m.       

Title to be announced​
Christoph A. Klein, University of Regensburg, Regensburg, Germany​

Molecular Characterization of DCC
Nikolas Stoecklein, University of Düsseldorf, Düsseldorf, Germany

​Evolution of lethal metastatic cancer at primary and metastatic sites, and in body fluids: can we identify what is important?
​​G. Steven Bova, University of Tampere, Tampere, Finland

​Additional speaker to be announced​


Closing Remarks
12:30 p.m.