September 27 - 30, 2018
Washington, DC, USA
Abstract submission deadline: Tuesday, July 10
Advance registration deadline: Monday, August 13
Conference CochairsAnil K. Rustgi, University of Pennsylvania, Philadelphia, PennsylvaniaJohanna Bendell, Sarah Cannon Research Institute, Nashville, TennesseeHans Clevers, Hubrecht Institute, Utrecht, NetherlandsChristina Curtis, Stanford University, Stanford, CaliforniaOwen Sansom, Beatson Institute for Cancer Research, Glasgow, United Kingdom
Non-hematopoietic tissue stem cells have garnered much attention in recent years, especially in the intestine/colon. Wnt and Notch signaling are critical in the regulation of cell lineages (absorptive vs. secretory) that emerge from these stem cells, whereas Hedgehog and other pathways are crucial for signals from the mesenchyme. These pathways influence the constitution of the stem cell niche. Stem cells can now be modeled in 3D organoid cultures, permitting the investigation of morphogenesis, elucidating the impact of developmental pathways and live cell imaging, and testing of therapeutics individually and in combination. It has been demonstrated that intestinal stem cells have the capacity to undergo malignant transformation, resulting in colon cancer. Genetic and epigenetic alterations in a variety of signaling pathways are responsible for the initiation and progression of colon cancer. In addition to these noted alterations, four consensus molecular classifications (CMS) subtypes summarize distinguishing features of colorectal cancer lesions. As a result, opportunities abound for translation into new avenues for early detection, risk stratification, and innovative therapies (targeted therapeutics and immunotherapy). This exciting AACR conference will appeal to students, fellows, scientists, physicians, industry representatives, and government officials.
Continuing Medical Education Activity AMA PRA Category 1 CreditsTM available