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FINDING CURES TOGETHER<sup>SM</sup>

Pancreatic Cancer: Advances in Science and Clinical Care

Program 

Friday, Sept. 6, 2019

Saturday, Sept. 7, 2019

Sunday, Sept. 8, 2019

Monday, Sept. 9, 2019


Friday, Sept. 6

Welcome and Keynote Addresses
6-7:30 p.m.

Welcome

Rising Star Keynote
Mechanisms and consequences of pancreatic cancer stromal evolution
Mara H. Sherman, Oregon Health and Science University, Portland, Oregon

Opening Keynote
Title to be announced
George Miller, New York University Langone Health Perlmutter Cancer Center, New York, New York


Poster Session A / Opening Reception

7:45-10 p.m.


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Saturday, Sept. 7

Continental Breakfast with Networking Roundtables
7:30-8:30 a.m.

Plenary Session 1: Tumor Microenvironment
Session Chair: Ben Z. Stanger, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
8:30-10:30 a.m.

Immune contexture of human pancreatic cancer
Lisa M. Coussens, Oregon Health and Science University, Portland, Oregon

Regulatory T cell depletion causes compensatory immune suppression and accelerates pancreatic carcinogenesis
Marina Pasca Di Magliano, University of Michigan, Ann Arbor, Michigan

Heterocellular interactions in the tumor microenvironment
Claus Jorgensen, Cancer Research UK Manchester Centre, Manchester, United Kingdom

2 short talks from proffered abstracts


Break

10:30-10:45 a.m.

Plenary Session 2: Genomics
Session Chair: Andrew Aguirre, Dana-Farber Cancer Institute, Boston, Massachusetts
10:45 a.m.-12:30 p.m.

Clonal evolution and progression of pancreatic cancer precursor lesions
Laura DeLong Wood, Johns Hopkins University, Baltimore, Maryland

Multimodal evolutionary dynamics of pancreatic cancer
Christine A. Iacobuzio-Donahue, Memorial Sloan Kettering Cancer Center, New York, New York

Molecular subtypes: Bench to bedside
Jen Jen Yeh, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

2 short talks from proffered abstracts

Poster Session B / Lunch
12:45-3:30 p.m.

Plenary Session 3: Immunology
Session Chair: Elizabeth M. Jaffee, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland
3:30-5:30 p.m.

Link between adaptive and innate immunity in pancreatic cancer
Stephanie K. Dougan, Dana Farber Cancer Institute, Boston, Massachusetts

Immune cell signaling in human and mouse pancreas cancer
Aida Habtezion, Stanford University, Stanford, California

Targeting pancreatic cancer with TCR-engineered T cells
Phil D. Greenberg, Fred Hutchinson Cancer Research Center, Seattle, Washington

2 short talks from proffered abstracts

Evening Off / Dinner on Own
5:30 p.m.


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Sunday, Sept. 8

Continental Breakfast with Networking Roundtables
7:30-8:30 a.m. 


Plenary Session 4: Early-Stage Trials and Novel Treatment Combinations
Session Chair: Luis A. Diaz, Memorial Sloan Kettering Cancer Center, New York, New York
8:30-10:30 a.m.

CD40 immunotherapy for pancreatic cancer
Robert H. Vonderheide, University of Pennsylvania Abramson Cancer Center, Philadelphia, Pennsylvania

Modulating the immune response with epigenetic agents
Nilofer S. Azad, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland

Title to be announced
Diane M. Simeone, New York University, New York, New York

2 short talks from proffered abstracts


Break
10:30-10:45 a.m.


Plenary Session 5: Ras and Oncogene Signaling
Session Chair: Dafna Bar-Sagi, New York University Langone Medical Center, New York, New York
10:45 a.m.-12:30 p.m.

Deciphering the origins of PDAC development
Laura D. Attardi, Stanford University School of Medicine, Stanford, California

KRAS and environmental signals regulate MYC to drive lineage plasticity, pancreas cancer progression and therapeutic resistance
Rosalie C. Sears, Oregon Health and Science University, Portland, Oregon

Wild-type KRAS in pancreatic cancer tumorigenesis
Gloria H. Su, Columbia University, New York, New York

2 short talks from proffered abstracts


Lunch on Own

12:45-2 p.m.

Plenary Session 6: Prevention and Early Detection
Session Chair: Anirban Maitra, The University of Texas MD Anderson Cancer Center, Houston, Texas
2-4 p.m.

Retooling a blood-based biomarker into a theranostic agent
Jason S. Lewis, Memorial Sloan Kettering Cancer Center, New York, New York

Early detection of pancreatic cancer: Challenges and opportunities
Anirban Maitra

Circulating tumor DNA in cancer diagnosis: Challenges and potential
Anne Marie O'Broin-Lennon, Johns Hopkins Hospital, Baltimore, Maryland

2 short talks from proffered abstracts

Poster Session C / Reception
4-6:30 p.m.

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Monday, Sept. 9

Continental Breakfast
7-8 a.m.

Plenary Session 7: Metabolism
Session Chair: Alec Kimmelman, New York University Langone Medical Center, New York, New York
8-9:45 a.m.

Title to be announced
Matthew G. Vander Heiden, David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts

New players and unique features of cancer lysosomes
Rushika M. Perera, University of California San Francisco, San Francisco, California

Identifying metabolic dependencies in pancreatic cancer
Alec C. Kimmelman

1 short talks from proffered abstract

Break
9:45-10 a.m.

Plenary Session 8: New Models, Systems, Animals, and Beyond
Session Chair: Tyler Jacks, David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts
10-11:45 a.m.

Title to be announced
Tyler Jacks

Title to be announced
Scott W. Lowe, Memorial Sloan Kettering Cancer Center, New York, New York

Modeling subtypes of human pancreatic cancer in mice
Jen P. Morton, Cancer Research UK Beatson Institute, Glasgow, United Kingdom

1 short talk from proffered abstract

Closing Keynote
11:45-12:30 p.m.

Title to be announced
Dung Thi Le, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland

Closing Remarks
12:30 p.m.

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