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FINDING CURES TOGETHER<sup>SM</sup>

Advancing Precision Medicine Drug Development: Incorporation of Real-World Data and Other Novel Strategies

Program 

Thursday, Jan. 9

Friday, Jan. 10


Saturday, Jan. 11


Thursday, Jan. 9

Welcome and Opening Keynote Lectures
6:30-8:15 p.m.

Welcome
Elaine R. Mardis, Nationwide Children's Hospital, Columbus, Ohio

Keynote address
Deborah Schrag, Dana-Farber Cancer Institute, Boston, Massachusetts

Panel Discussion
Amy P. Abernethy, U.S. Food and Drug Administration, Silver Spring, Maryland

David M. Hyman, Memorial Sloan Kettering Cancer Center, New York, New York

Elaine R. Mardis

Deborah Schrag

Lillian L. Siu, Princess Margaret Cancer Centre, Toronto, ON, Canada

Eliezer M. Van Allen, Dana-Farber Cancer Institute, Boston, Massachusetts

Opening Reception
8:15-10 p.m.


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Friday, Jan. 10

Continental Breakfast
7-8 a.m.


Plenary Session 1: Machine Learning in Precision Oncology
Session Chair: Lillian L. Siu, Princess Margaret Cancer Centre, Toronto, ON, Canada
8-9:45 a.m.

The Treehouse Childhood Cancer Initiative
David Haussler, University of California, Santa Cruz, California

Drug predictive computational evaluations
Benjamin Haibe-Kains, Princess Margaret Cancer Centre, Toronto, ON, Canada

AI in oncological imaging: From workflow to integrated diagnostics
Evis Sala, University of Cambridge, Cambridge, United Kingdom

Panel Discussion

Break
9:45-10 a.m.


Plenary Session 2: Databases and EHRs
Session Chair: Eliezer M. Van Allen, Dana-Farber Cancer Institute, Boston, Massachusetts
10-11:45 a.m.

EHR-derived data platforms to advance precision medicine
Neal J. Meropol, Flatiron Health, New York, New York

Count me in: Partnering with patients to accelerate the pace of discoveries
Corrie Painter, Broad Institute of Harvard and MIT / CountMeIn, Cambridge, Massachusetts

Making it easier to participate in research: A patient’s perspective
Liz Salmi, OpenNotes / Beth Israel Deaconess Medical Center, Boston, Massachusetts

Panel Discussion


Poster Session / Lunch (provided)
12-2:45 p.m.


Plenary Session 3: Panel Discussion on Real-World Evidence Generation, Payment Models, and Endpoints
Session Moderator: Elaine R. Mardis, Nationwide Children's Hospital, Columbus, Ohio
3-4:45 p.m.

Finding the right patient, finding the right trial
Lee Newcomer, Lee N. Newcomer Consulting, Wayzata, Minnesota

Title to be announced
Monica M. Bertagnolli, Brigham and Women's Hospital, Boston, Massachusetts

Title to be announced
Levi A. Garraway, Genentech, South San Francisco, California

A platform approach to regulatory-grade RWE and outcomes validation
Jonathan Hirsch, Syapse, San Francisco, California

Panel Discussion


Dinner on Own / Free Time
4:45 p.m.

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Saturday, Jan. 11

Continental Breakfast
7-8 a.m.


Plenary Session 4: Novel Drug Development Approaches / Drugging Difficult Targets
Session Chair: David M. Hyman, Memorial Sloan Kettering Cancer Center, New York, New York
8-9:45 a.m.

Title to be announced
José Baselga, AstraZeneca, Gaithersburg, Maryland

Title to be announced
Jeffrey A. Engelman, Novartis, Cambridge, Massachusetts

Title to be announced
Levi A. Garraway, Genentech, South San Francisco, California

Panel Discussion


Break
9:45-10 a.m.


Plenary Session 5: What Constitutes Adequate Screening?
Session Chair: Elaine R. Mardis, Nationwide Children's Hospital, Columbus, Ohio
10-11:45 a.m.

Title to be announced
Barry S. Taylor, Memorial Sloan Kettering Cancer Center, New York, New York

Longitudinal single cell DNA sequencing to reveal rare cancer cell populations and genome-phenome states in tumors
Sohrab Shah, Memorial Sloan Kettering Cancer Center, New York, New York

Title to be announced
Alexandra Snyder, Merck & Co., Rahway, New Jersey

Panel Discussion


Lunch (provided) / Free Time
12-2 p.m.


Plenary Session 6: Unique Clinical Trial Designs
Session Chair: Lillian L. Siu, Princess Margaret Cancer Centre, Toronto, ON, Canada
2:15-4 p.m.

Title to be announced
J. Carl Barrett, AstraZeneca, Waltham, Massachusetts

The Drug Rediscovery protocol: Getting the most out of approved drugs
Emile E. Voest, Netherlands Cancer Institute, Amsterdam, Netherlands

Title to be announced
David M. Hyman, Memorial Sloan Kettering Cancer Center, New York, New York

Panel Discussion


Dinner on Own / Free Time
4 p.m.


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Sunday, Jan. 12

Continental Breakfast
7-8 a.m.


Keynote Lecture
Session Chair: Eliezer M. Van Allen, Dana-Farber Cancer Institute, Boston, Massachusetts
8-9:10 a.m.

Large scale science in the private sector: The Story of Grail and the early detection of cancer
Richard D. Klausner, Lyell Immunopharma, South San Francisco, California


Plenary Session 7: Panel Discussion on Perspectives from Biotech and the Finance Sector
Moderators: J. Carl Barrett, AstraZeneca, Waltham, Massachusetts, and and David M. Hyman, Memorial Sloan Kettering Cancer Center, New York, New York
9:15-10:30 a.m.

Philip Dreyfuss, Farallon Capital, San Francisco, California

Thomas G. Roberts, Farallon Capital, San Francisco, California

James Tanenbaum, Foresite Capital, San Francisco, California

Caroline Savello, Color Genomics, Burlingame, California


Break
10:30-10:45 a.m.


Plenary Session 8: MRD / Advanced Diagnostics
Session Chair: Eliezer M. Van Allen, Dana-Farber Cancer Institute, Boston, Massachusetts
10:45 a.m.-12:30 p.m.

Title to be announced
Eliezer M. Van Allen, Dana-Farber Cancer Institute, Boston, Massachusetts

ctDNA as predictive biomarkers for response and toxicity with immunotherapy
Lillian L. Siu, Princess Margaret Cancer Centre, Toronto, ON, Canada

Title to be announced
Maximilian Diehn, Stanford University, Stanford, California

Panel Discussion


Closing Remarks and Departure
12:30 p.m.


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