Program
Please note that this special conference will take place as an in-person event in Boston and will not live-stream content for virtual participation. The conference content will be recorded and made available as an on-demand program after the conference.
CME credit is available for in-person attendance for the designated sessions. On-demand presentations are not eligible for CME.
All presentations are scheduled to be live, in-person presentations at the date and time specified below unless noted otherwise. Program in progress.
Sunday, September 15
monday, September 16
- Plenary Session 1: Cachexia, Diet, and Metabolism
- Plenary Session 2: Immunology and Immunotherapy
- Plenary Session 3: Stromal Aspects of the Microenvironment and Tumor Microenvironment
tuesday, September 17
- Plenary Session 4: KRAS Resistance, Mechanisms, and Therapeutics
- Plenary Session 5: KRAS Cell Biology
- Plenary Session 6: Early Detection and Interception of Precursor Lesions
- Plenary Session 7: Tumor Cell Biology
wednesdayday, September 18
- Plenary Session 8: Plasticity
- Plenary Session 9: Metabolism
- Debate: Have We Learned Anything from the KRAS Inhibitors That We Didn’t Already Know from Mice?
REGISTRATION
3-8 p.m. | America Ballroom Foyer
WELCOME AND Keynote lectures
5:30-7:15 p.m. | American Ballroom Center & North | CME Eligible
- Welcome from Conference Cochairs
- Keynote Lecture
Pancreas Cancer 2024: Translating genomic findings into clinical actionability
Eileen M. O’Reilly, Memorial Sloan Kettering Cancer Center, New York, New York - Rising Star Keynote
Title to be announced
Joseph D. Mancias, Dana-Farber Cancer Institute, Boston, Massachusetts
Lightning Presentation Session A
7:20-7:40 p.m. | American Ballroom Center & North | CME Eligible
POSTER SESSION A AND OPENING RECEPTION
7:45-10 p.m. | American Ballroom South
CONTINENTAL BREAKFAST
7-8 a.m. | Essex Ballroom (3rd Floor)
Career Development Roundtable Session 1
7-8 a.m. | Essex Ballroom (3rd Floor)
Attendance to each of the Career Roundtables will be on a first-come, first-served basis and no pre-registration is required. Participants may rotate to as many tables as they like during the session, providing the opportunity to network and interact with a diverse cadre of experts. Topics and speakers to be announced.
Plenary Session 1: Cachexia, Diet, and Metabolism
8:15-9:55 a.m. | American Ballroom Center & North | CME Eligible
- Mechanisms of pancreatic cancer cachexia
Teresa A. Zimmers, Oregon Health & Science University Knight Cancer Institute, Portland, Oregon - Developing therapies for pancreatic cancer cachexia
Andrew E. Hendifar, Cedars Sinai Medical Center, Los Angeles, California - Neuroendocrine causes and effects of cachexia
Tobias Janowitz, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
Short talks selected from proffered abstracts
break
9:55-10:30 a.m. | American Ballroom Foyer
PLENARY SESSION 2: Immunology and Immunotherapy
10:30 a.m.-12:10 p.m. | American Ballroom Center & North | CME Eligible
- The tumor-reactive CD8+ T-cell repertoire in pancreatic cancer as revealed by single-cell sequencing
Rienk Offringa, German Cancer Research Center, Heidelberg, Germany - Investigating the role of CD4 T cells in the pancreatic tumor microenvironment
Katelyn T. Byrne, Oregon Health and Science University, Portland, Oregon - Exploiting functional specialization of myeloid-derived suppressor cells to overcome therapeutic resistance in pancreatic cancer
Jashodeep Datta, University of Miami Miller School of Medicine, Miami, Florida
Short talks selected from proffered abstracts
lunch on own
12:15-2:30 p.m.
Plenary Session 3: Stromal Aspects of the Microenvironment and Tumor Microenvironment
2:30-4:10 p.m. | American Ballroom Center & North | CME Eligible
- Functional heterogeneity of fibroblast populations in pancreatic cancer
Giulia Biffi, University of Cambridge, Cancer Research UK Cambridge Institute, Cambridge, United Kingdom - Mechanisms and consequences of pancreatic cancer stromal evolution
Mara Sherman, Memorial Sloan Kettering Cancer Center, New York, New York - Targeting the tumor microenvironment to improve responses to therapy
David G. DeNardo, Washington University School of Medicine in St. Louis, St. Louis, Missouri
Short talks selected from proffered abstracts
lightning presentation b
4:15-4:35 p.m. | American Ballroom Center & North | CME Eligible
Poster session b/reception
4:45-7 p.m. | American Ballroom South
CONTINENTAL BREAKFAST
7-8 a.m. | Essex Ballroom (3rd Floor)
Career Development Roundtable Session 1
7-8 a.m. | Essex Ballroom (3rd Floor)
Attendance to each of the Career Roundtables will be on a first-come, first-served basis and no pre-registration is required. Participants may rotate to as many tables as they like during the session, providing the opportunity to network and interact with a diverse cadre of experts. Topics and speakers to be announced.
Plenary Session 4: KRAS Resistance, Mechanisms, and Therapeutics
8:15-9:55 a.m. | American Ballroom Center & North | CME Eligible
- Mechanisms of resistance to oncogenic KRAS inhibition in pancreatic cancer
Andrew Aguirre, Dana-Farber Cancer Institute, Boston, Massachusetts - Adaptation and resistance to pan-RAS inhibition in pancreatic ductal adenocarcinoma
Kenneth P. Olive, Columbia University Irving Medical Center, New York, New York - Targeting the oncogenic state of RAS with tri-complex inhibitors
Mallika Singh, Revolution Medicines, Redwood City, California
Short talks selected from proffered abstracts
break
9:55-10:30 a.m. | American Ballroom Foyer
Plenary Session 5: KRAS Cell Biology
10:30 a.m.-12:15 p.m. | American Ballroom Center & North | CME Eligible
- Targeting KRAS for pancreatic cancer treatment
Channing Der, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina - Piro Lito, Memorial Sloan Kettering Cancer Center, New York, New York
- Elucidation of metabolic resistance mechanisms to RAS inhibition
Kirsten Bryant, University of North Carolina, Chapel Hill, North Carolina - RAS mutation tropism: Why distinct RAS mutations drive specific cancers
Christopher M. Counter, Duke University School of Medicine, Durham, North Carolina
Short talks selected from proffered abstracts
lunch on own
12:30-2:45 p.m.
Plenary Session 6: Early Detection and Interception of Precursor Lesions
2:30-4:15 p.m. | American Ballroom Center & North| CME Eligible
- Peter J. Allen, Duke University School of Medicine, Durham, North Carolina
- Multimodal tools for noninvasive cancer monitoring
Erica D. Pratt, Boston University, Boston, Massachusetts - Improving pancreatic cancer early detection using a tumor marker gene test
Michael G. Goggins, Johns Hopkins University, Baltimore, Maryland
Short talks selected from proffered abstracts
Break
4:15-4:45 p.m. | American Ballroom Foyer
Plenary Session 7: tumor cell biology
4:45-6:10 p.m. | American Ballroom Center & North | CME Eligible
- Targeting Syndecan1 in pancreatic cancer
Wantong Yao, The University of Texas MD Anderson Cancer Center, Houston, Texas - Stress-induced O-glycans drive immunosuppression in pancreatic cancer
Tobiloba Oni, Whitehead Institute, Cambridge, Massachusetts - Metabolic adaptations to autophagy inhibition
Christina Towers, The Salk Institute for Biological Studies, La Jolla, California
Short talks selected from proffered abstracts
lightning presentation session c
6:15-6:35 p.m. | American Ballroom Center & North | CME Eligible
poster session c/reception
6:45-9 p.m. | American Ballroom South
CONTINENTAL BREAKFAST
7-8 a.m. | Essex Ballroom (3rd Floor)
Plenary Session 8: plasticity
8-9:45 a.m. | American Ballroom Center & North | CME Eligible
- Stephanie K. Dougan, Dana-Farber Cancer Institute, Boston, Massachusetts
- Regulation of tumor and stromal cell plasticity by metabolic stress
Cosimo Commisso, Sanford Burnham Prebys, San Diego, California - The role of methionine oxidation in pancreatic tumorigenesis
Christine Chio, Columbia University, New York, New York - Nicholas T. Woods, University of Nebraska Medical Center, Omaha, Nebraska
break
9:45-10:15 a.m. | American Ballroom Foyer
Plenary Session 9: metabolism
10:15-11:55 a.m. | American Ballroom Center & North | CME Eligible
- Alec C. Kimmelman, NYU Langone Health, New York, New York
- Systemic metabolic networks in pancreatic cancer and associated cachexia
Nada Kaalany, Harvard Medical School / Boston Children’s Hospital, Boston, Massachusetts - Targeting lipid metabolism in pancreatic cancer
Costas A. Lyssiotis, University of Michigan Medical School, Ann Arbor, Michigan - Metabolic competition in pancreatic tumor microenvironment regulates innate immune responses
Kamiya Mehla, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
debate: Have We Learned Anything from the KRAS Inhibitors That We Didn’t Already Know from Mice?
12:00-12:45 p.m. | American Ballroom Center & North | CME Eligible
- Andrew Aguirre, Dana-Farber Cancer Institute, Boston, Massachusetts
- Marina Pasca Di Magliano, University of Michigan, Ann Arbor, Michigan
Departure
12:45 p.m.