In This Section

Program

Please Note: All session times for the AACR Virtual Meeting: Clonal Hematopoiesis are U.S. Eastern Standard Time (EST).

Wednesday, August 18, 2021

Thursday, August 19, 2021

WEDNESDAY, AUGUST 18, 2021

Sessions 1 and 2: DTA and non-dta Mutations
Moderator: Ross L. Levine, Memorial Sloan Kettering Cancer Center, New York, New York
10 a.m.-1 p.m.

Session 1 and 2 Introduction
Ross L. Levine

SESSION 1: DTA MUTATIONS
10:10-11:10 a.m.

Dnmt3A mutations in clonal hematopoiesis
Jennifer Trowbridge, The Jackson Laboratory, Bar Harbor, Maine

TET2 mutations and clonal hematopoiesis
Iannis Aifantis, New York University Langone Medical Center, New York, New York

Title to be announced
Ravi Majeti, Stanford University, Stanford, California

Break
11:10-11:25 a.m.
Session 2: Non-DTA Mutations
11:25 a.m.-12:05 p.m.

Mechanisms of clonal competition in the context of PPM1D mutations
Margaret A. Goodell, Baylor College of Medicine, Houston, Texas

Spliceosome mutations in clonal hematopoiesis
Esther Obeng, St. Jude Children’s Research Hospital, Memphis, Tennessee

DTA vs. Non-DTA Panel Discussion
Moderator: Ross L. Levine, MEMORIAL SLOAN KETTERING CANCER CENTER, NEW YORK, NEW YORK

Panelists
Jennifer Trowbridge
Iannis Aifantis
Ravi Majeti
Margaret A. Goodell
Esther Obeng

THURSDAY, AUGUST 19, 2021

Session 3: Clonal Hematopoiesis and Non-Blood Cancer Consequences
Moderator: Benjamin L. Ebert, Dana-Farber Cancer Institute, Boston, Massachusetts
10-11:25 a.m.

Session Introduction
Benjamin L. Ebert

Clonal hematopoiesis and risk of cardiovascular diseases
Siddhartha Jaiswal, Stanford University, Stanford, California

Title to be announced
Kelly L. Bolton, Washington University of St. Louis, St. Louis, Missouri

Title to be announced
Ross L. Levine, Memorial Sloan Kettering Cancer Center, New York, New York

Panel Discussion
Siddhartha Jaiswal
Kelly Bolton
Ross L. Levine

Break
11:25-11:40 a.m.
Session 4: Population-Level Studies of Clonal Hematopoiesis
Moderator: Maria E. (Ken) Figueroa, University of Miami, Miami, Florida
11:40 a.m.-1:20 p.m.

Session Introduction
Maria E. (Ken) Figueroa

Title to be announced
Kirsten Grønbæk, Rigshospitalet, Copenhagen, Denmark

Population-level studies of clonal hematopoiesis
Pinkal Desai, Weill Cornell Medical College, New York, New York

Clonal hematopoiesis and risk for cardiovascular disease: Insights from population-based studies
Pradeep Natarajan, Massachusetts General Hospital, Boston, MA

Title to be announced
Jyoti Nangalia, Wellcome Sanger Institute and University of Cambridge, Cambridge, United Kingdom

Panel Discussion
Pinkal Desai
Jyoti Nangalia
Pradeep Natarajan

Break
1:15-1:30 p.m.
Panel Discussion
Clonal Hematopoiesis: How Do We Design Clinical Trials and Approve Drugs?
Moderators: Ravi Majeti, Stanford University, Stanford, California, and Maria E. (Ken) Figueroa, University of Miami, Miami, Florida

Panelists
Kelly L. Bolton, Washington University of St. Louis, St. Louis, Missouri
Benjamin L. Ebert, Dana-Farber Cancer Institute, Boston, Massachusetts
David Steensma, Novartis, Cambridge, Massachusetts