In This Section

Program

Please Note: All session times for the AACR Virtual Meeting: Colorectal Cancer are U.S. Eastern Daylight Time (EDT).

THURSDAY, OCTOBER 21, 2021

Friday, October 22, 2021

THURSDAY, OCTOBER 21, 2021

Welcome and Opening Keynote Address
11-11:45 a.m.

Welcome and Introduction of Keynote Speaker
Scott Kopetz, The University of Texas MD Anderson Cancer Center, Houston, Texas

Keynote Address
Colorectal cancer genetics – new opportunities for cancer prevention
Ulrike Peters, Fred Hutchinson Cancer Research Center, Seattle, Washington

Break
11:45 a.m.-12 p.m.
Session 1: Early Onset/Epidemiology
12-1:40 P.m.

Early-onset colorectal cancer: What have we learned and where do we go from here?
Caitlin C. Murphy, UT Health Science Center, Houston, Texas

Society meets biology: Racial/ethnic disparities in early-onset colorectal cancer
Andreana N. Holowatyj, Vanderbilt University Medical Center, Nashville, Tennessee

Colorectal cancer screening in adults 45 to 49 years old: Different side of the same coin?
Rachel Issaka, Fred Hutchinson Cancer Research Center, Seattle, Washington

Q&A / Panel Discussion

Break
1:40-1:55 p.m.
Session 2: Microbiome
Session Chair: Jiyoung Ahn, New York University Perlmutter Cancer Center, New York, New york
1:55-3:35 p.m.

Integrated epidemiologic research on diet and gutmicrobiome for improved colorectal cancer prevention
Mingyang Song, Harvard University, Boston, Massachusetts

Beans to enrich the gut microbiome vs. obesity’s negative effects: First results from the BE GONE Trial in high-risk colorectal patients
Carrie R. Daniel-MacDougal, The University of Texas MD Anderson Cancer Center, Houston, Texas

Mining the gut microbiota for novel procarcinogenic microbes reveals clostridioides difficileas a driver of colonic tumorigenesis
Julia L. Drewes, Johns Hopkins Medicine, Baltimore, Maryland

Q&A / Panel Discussion

Closing Remarks
3:35-3:45 p.m.

Jiyoung Ahn, New York University Perlmutter Cancer Center, New York, New York

FRIDAY, OCTOBER 22, 2021

Keynote Address
11-11:45 a.m.

Introduction of Keynote Speaker
Robert J. Coffey, Vanderbilt University Medical Center, Nashville, Tennessee

Keynote Address
High dose vitamin C and inactivation of DNA repair boost colorectal cancer Immunotherapy
Alberto Bardelli, University of Turin School of Medicine, Candiolo, Italy

Break
11:45 a.m.-12 P.M.
Session 3: Clinical / Translational
Session Chair: Scott Kopetz, The University of Texas MD Anderson Cancer Center, Houston, Texas
12-2 p.m.

Colorectal Cancer: Strategies to make cold tumors hot
Aparna Parikh, Massachusetts General Hospital, Boston, Massachusetts

A rectal cancer organoid platform to study individual responses to chemoradiation
J. Joshua Smith, Memorial Sloan Kettering Cancer Center, New York, New York

Cells, gene programs, and spatially organized immune hubs in MMRd and MMRp colorectal cancer
Karin Pelka, Gladstone-UCSF Institute of Genomic Immunology, Gladstone Institutes, San Francisco, California

Translating research into practice–refining RAS and tumor mutation burden (TMB) as predictive biomarkers in metastatic colorectal cancer
Jonathan Loree, Vancouver Coastal Health Research Institute, Vancouver, BC,
Canada

Q&A / Panel Discussion

Break
2-2:15 p.m.
Session 4: Models
Session Chair: Robert J. Coffey, Vanderbilt University Medical Center, Nashville, Tennessee
2:15-4:15 p.m.

A pathomimetic colorectal cancer chip
Hyun Jung Kim, University of Texas, Austin, Texas

In vivo colorectal cancer modeling for research and personalized medicine
Jatin Roper, Duke University School of Medicine, Durham, North Carolina

Modeling human colon cancer-associated biofilms and microbial toxin-induced tumorigenesis
Nicholas O. Markham, Vanderbilt University Medical Center, Nashville, Tennessee

Models of colorectal cancer initiation demonstrate importance of differentiation blocks
Nilay S. Sethi, Dana-Farber Cancer Institute, Boston, Massachusetts

Q&A / Panel Discussion

Closing Remarks
4:15 p.m.

Robert J. Coffey, Vanderbilt University Medical Center, Nashville, Tennessee