In This Section

Program

Beginning at 3 p.m. on Friday, April 9, and continuing until 3:30 p.m. on Saturday, April 10, 2021, a program of Educational Sessions and Methods Workshops will be presented. An Educational Program Pass granting access to the complete educational program will be available for purchase when registration opens.

On Saturday at 3:45 p.m., an exciting new Discovery Science Featured Plenary Session will be open to all registrants. The Opening Ceremony and the Opening Plenary Session will take place on Sunday morning, April 11. The meeting will conclude at 1:30 p.m. on Wednesday, April 14.

Abstracts submitted for the regular (November 19, 2020) or late-breaking and clinical trials (January 11, 2021) submission deadlines will be considered for short talks or ePoster presentations. The 2021 Program in Progress follows; additional exciting and timely invited sessions are being developed and will be posted.

PLENARY SESSIONS

Saturday, April 10, 2021

Discovery Science Plenary Session: Mechanisms, Impact, and Exploitation of Cancer Chromosomal Instability

David Pellman, Dana-Farber Cancer Institute, Boston, Massachusetts

Angelika Amon, Massachusetts Institute of Technology, Cambridge, Massachusetts

Stephen P. Jackson, University of Cambridge, Cambridge, United Kingdom

Karlene A. Cimprich, Stanford University, Stanford, California

Sunday, April 11, 2021

Opening Plenary Session: Discovery Science Driving Clinical Breakthroughs
Chair: Charles Swanton, The Francis Crick Institute, London, United Kingdom

Jonathan S. Weissman, Whitehead Institute, Cambridge, Massachusetts

Karen H. Vousden, The Francis Crick Institute, London, United Kingdom

Matthew G. Vander Heiden, Massachusetts Institute of Technology, Cambridge, Massachusetts

Melissa B. Davis, Weill Cornell Medical College, New York, New York

Mark A. Dawson, Peter MacCallum Cancer Centre, Melbourne, Australia

Zhijan James Chen, UT Southwestern Medical School, Dallas, Texas

Monday, April 12, 2021

Understanding the Molecular and Microenvironmental Determinants of Cancer
Chair: Christina Curtis, Stanford University, Stanford, California

Garry P. Nolan, Stanford University School of Medicine, Stanford, California

Serena Nik-Zainal, University of Cambridge, Cambridge, United Kingdom

Ross L. Levine, Memorial Sloan Kettering Cancer Center, New York, New York

Jérôme Galon, INSERM, Paris, France

Tuesday, April 13, 2021

Cancer Biology and the Changing Therapeutic Landscape
Chair: Sheila A. Stewart, Washington University, St. Louis, Missouri 

Tony Hunter, Salk Institute, La Jolla, California

William G. Kaelin, Jr., Dana-Farber Cancer Institute, Boston, Massachusetts

Olufunmilayo I. Olopade, University of Chicago Medicine Comprehensive Cancer Center, Chicago, Illinois

Dennis J. Slamon, UCLA David Geffen School of Medicine, Los Angeles, California

Wednesday, April 14, 2021

Leveraging the Immune System in the War on Cancer
Chair: Nina Bhardwaj, Icahn School of Medicine at Mount Sinai, New York, New York

Anjana Rao, La Jolla Institute for Immunology, La Jolla, California

Sergio A. Quezada, University College London Cancer Institute, London, United Kingdom

Michel Sadelain, Memorial Sloan Kettering Cancer Center, New York, New York

Ignacio Melero, University of Navarra, Pamplona, Spain

MAJOR SYMPOSIA

  • AACR-Bayard D. Clarkson Symposium on Stem Cells, Leukemia, and the Niche
  • Advances in Cancer Nanotechnology
  • Alternative DNA Repair Pathways and Their Drug Targets
  • Artificial Intelligence in Cancer Imaging
  • Artificial Intelligence/Machine Learning in Cancer Research and Care: Progress and Opportunities
  • Cancer Immunometabolism
  • Colorectal Cancer Interception: Immunologic and Pharmacologic Advances
  • COVID-19 and Cancer Research
  • Cytokine Receptors in Immuno-oncology: Discovery, Analysis, and Modulation
  • Deubiquitylating Enzymes as Targets for Cancer Therapy
  • Developing Rational Combinations of Targeted Drugs
  • Diet, Clock, and Cancer
  • Drugging KRAS
  • Engineering and Modulating Natural Killer Cells for Cancer Immunotherapy
  • Familial Predisposition: Precision Medicine and Targeted Therapy
  • From ‘Omics Data to Prognostic and Predictive Biomarkers
  • Functional Precision Medicine in Cancer
  • Germline Influence on Immunotherapy Outcomes
  • Implications of Clonal Hematopoiesis in Human Health
  • Improving Therapy through Normalization of the Tumor Microenvironment
  • Matrix, Exosomes, and TME Cells in the Metastatic Niche
  • Mechanisms and Biomarkers of Response and Resistance to Immunotherapy
  • Metabolism and Chromatin Deregulation in Cancer and Cancer Heterogeneity
  • Modeling Metastatic Progression in the Mouse
  • Molecular Imaging
  • Neoadjuvant Immunotherapy for Melanoma and Other Cancers
  • New Approaches to Chimeric Antigen Receptor Engineering
  • New Combinations of Targeted Therapies and Immunotherapies
  • Next Frontiers in Adjuvant Therapy
  • Next-Generation Epigenetic Drugs
  • Options and Opportunities for Treating Metastasis
  • Paracrine Signaling in Cancer
  • Phase Separation, Transcription, and Cancer
  • Progress from Personalized Cancer Vaccine Trials
  • T Cells in Cancer
  • The Cancer Dependency Map
  • The Clinical Proteomic Tumor Analysis Consortium: Building a Proteogenomic Atlas of Cancer
  • The Microbiome in Cancer Therapy: Hype or Hope?
  • The Tumor Microbiome and Its Role in Oncogenesis and Modulating Therapy Response
  • Toward Engineering of Neoantigen-Specific T-Cell Therapies
  • Tumor Cell Plasticity and Resistance to Cancer Therapies
  • Tumor Hypoxia and Genetic Instability: New Mechanisms and New Targets
  • When Is Transforming Growth Factor Beta Targetable?
  • AACR-ASCO Joint Session: Targets in the Treatment of Renal Cell Cancer
  • AACR-CSCO Joint Symposium: Single-Cell Analysis— Changing the Landscape of Cancer Research
  • AACR-JCA Joint Session: Tracking Tumor Evolutionary Dynamics: From Initiation through Metastasis
  • AACR-ONS Special Session: Symptom Science

ADVANCES IN DIAGNOSTICS AND THERAPEUTICS

  • Advances in Drug Delivery
  • Computational Methods for Immunogenomics and Precision Oncology
  • Diagnostic Tests for Immunotherapy: Current CLIA Lab Testing and Future Directions
  • DNA Damage Response (DDR) Treatment: Evolving Diagnostic Approaches, Understanding of Replication Stress, and Resistance Mechanisms to DDR Targeting Therapies
  • Hybrid Technologies for Cancer Imaging, Theranostics, and Image-Guided Interventions
  • Management of Toxicity of Immune Cell Therapy
  • Noninvasive Monitoring of Minimal Residual Disease with Liquid Biopsies: Toward Real-Time Treatment Decision-Making
  • Proton Therapy and FLASH Irradiation
  • Targeting Transcriptional Cyclin-Dependent Kinases in Cancer
  • Translational Canine Models Advancing Immunotherapy and Immunogenomics
  • Understanding and Overcoming Resistance to Third Generation EGFR and ALK Inhibitors

ADVANCES IN ORGAN SITE RESEARCH

  • Advances in Endometrial Cancer
  • Advances in Sarcoma Therapy
  • Developing More Effective Treatments for Triple-Negative Breast Cancer
  • Diffuse Large B-Cell Lymphoma
  • Emerging Concepts in Liver Cancer Research
  • Next-Generation Treatments for Melanoma: Building on Success
  • Pathways to Early Detection of Pancreatic Cancer
  • Solid Tumor Brain Metastasis
  • Targeting Signaling Pathways in Colorectal Cancer
  • Therapeutic Advances in Biliary Tract Cancers
  • Therapeutic Vulnerabilities and Resistance Mechanisms in Estrogen Receptor-Positive Breast Cancer

ADVANCES IN PREVENTION, EARLY DETECTION, AND INTERCEPTION

  • Connecting the Tumor Microenvironment with the Macroenvironment in Cancer Cachexia
  • Interception of Preneoplasia
  • Molecular Targets of Precision Prevention and Interception
  • Panel on Rural Cancer Control
  • Radiation-Induced Cancers and Cancer Survivorship

ADVANCES IN THE SCIENCE OF CANCER HEALTH DISPARITIES

  • Carcinogenic Exposures and Global Cancer Prevention
  • Pan-Cancer Distinctions in Tumor Biology across Ethnicity and Genetic Ancestry
  • Precision Medicine in Underserved Populations

FORUMS

  • Are Antitumor T Cells Exhausted or Dysfunctional? Does It Matter?
  • Are There Cancer Stem Cells?
  • Biostatistics Debate: Should Science Be Guided by P-Values?
  • Cancer Cell Dormancy: The Current Paradigm and the Challenges Ahead to Develop New Therapies
  • CAR T-Cell Therapy or T-Cell Engager?
  • Data Science and Machine Learning: Will They Revolutionize Cancer Cure and Research?
  • Embracing Entrepreneurship in Cancer Research
  • Microbiome Pandemonium: Checkpoints and the Microbiome
  • Patient-Derived Models for Cancer
  • The Myths and Realities of the Abscopal Effects
  • What Is the Role for Oncolytic Viruses in Cancer Treatment?

EDUCATIONAL PROGRAM: EDUCATIONAL SESSIONS AND METHODS WORKSHOPS

Educational programming will begin on Friday,  April 9, at 3:00 p.m. and continue through 3:30 p.m. on Saturday, April 10. The Educational Program is an integral part of the meeting and provides attendees with an opportunity to expand their knowledge base. Meeting registrants will be able to purchase an Educational Program Pass granting access to the complete educational program of more than 65 unique sessions covering all areas of cancer research, including the popular multi-session programs noted below. 

  • Tumor Immunology and Immunotherapy for Nonimmunologists. Annually, this two-part series combines a comprehensive review of a hot topic in the field with a roundtable session that enables attendees to participate in group discussions with leading experts in the field.
  • Chemistry to the Clinic. This three-part series provides attendees with foundational knowledge of critical elements of the drug development process, such as lead optimization, identification of targets, and drug modalities.
  • Clinical Trial Design. Over the course of three consecutive sessions, this Methods Workshop will provide attendees with a historical and methodologic understanding of clinical trials and demonstrate how to design an appropriate trial to answer the scientific questions presented by emerging treatments.

Policy Sessions

Decisions made by policymakers in Washington, DC, have a direct impact on cancer research and the progress being made against cancer in the United States and throughout the world. The AACR sponsors sessions with policymakers, academic researchers, patient advocates, cancer survivors, and industry representatives to foster dialogue about emerging topics in science and health policy, and regulatory science and policy.

  • The Science and Health Policy Track includes sessions that will provide attendees with an opportunity to learn about how policy impacts science and vice versa. Science policy sessions will examine the current political environment affecting federal funding for the NIH and NCI, including highlighting ways for scientists to get involved in advocating for robust, sustained, and predictable budget increases. Health policy sessions will explore how scientific evidence can inform policy on cancer prevention and control and what impact policies are having on patients and communities. Past health policy sessions have covered topics such as e-cigarettes and tobacco control measures, the Affordable Care Act, and ways to prevent and control pathogen-related cancers, such as increasing the use of the human papillomavirus (HPV) vaccine.
  • The Regulatory Science and Policy Track includes informative sessions designed to highlight recent regulatory developments and provide an open forum for the consideration of issues that the FDA faces as the agency seeks to accelerate the pace of approval of safe and effective treatments for patients with cancer. These sessions offer an opportunity for attendees to discuss cutting-edge issues in cancer drug, biologic, and diagnostic regulation with stakeholders from academia, industry, advocacy, and government. Past regulatory science and policy topics have included strategies for increasing participation of underrepresented populations in clinical trials, guidance for using real-world evidence to support clinical trials during the COVID-19 pandemic, regulatory considerations for developing liquid biopsy tests, implications of site-agnostic therapy approval for drug development, and applications for artificial intelligence/machine learning in regulatory decision-making.
  • The Science of Survivorship Track includes sessions highlighting new and high-value areas of research to address the array of challenges facing longterm cancer survivors. Sessions invite trans-sector discussion among the survivor and advocacy communities, basic and clinical researchers, industry representatives, health care providers, and government officials. Past science of survivorship topics have included aging and cancer, long-term survivorship and vulnerable populations, development of new survivorship models, patient-reported outcomes, data sharing, and patient engagement.