The AACR Annual Meeting is the focal point of the cancer research community, the place where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in research and medicine. A comprehensive summary of the cutting-edge cancer science presented at the meeting is available through the resources below.

Several high-impact studies presented at the Annual Meeting were simultaneously published in AACR journals:

Cancer Discovery

• Netrin G1 promotes pancreatic tumorigenesis through cancer-associated fibroblast–driven nutritional support and immunosuppression (Presenter: Edna Cukierman)
• Oncogenic KRAS recruits an expansive transcriptional network through mutant p53 to drive pancreatic cancer metastasis (Presenter: Michael P. Kim)
• Werner helicase is a synthetic-lethal vulnerability in mismatch repair-deficient colorectal cancer refractory to targeted therapies, chemotherapy, and immunotherapy (Presenter: Mathew J. Garnett)

Blood Cancer Discovery

• Lysine demethylase 5A is required for MYC-driven transcription in multiple myeloma (Presenter: Jun Qi)
• Dissecting clonal hematopoiesis in tissues of patients with classic hodgkin lymphoma (Presenter: Andrea Marra)
• ROBO1 promotes homing, dissemination, and survival of multiple myeloma within the bone marrow microenvironment (Presenter: Giada Bianchi)
• SIRT5 is a druggable metabolic vulnerability in acute myeloid leukemia (Presenter: Dongqing Yan)
  Non-oncogene addiction to SIRT5 in acute myeloid leukemia (Related perspective by Meng Li and Ari M. Melnick)
• Clinical significance of novel subtypes of acute lymphoblastic leukemia in the context of minimal residual disease-directed therapy (Presenter: Sima Jeha)

Cancer Immunology Research

• Chemotherapy induces tumor-associated macrophages that aid adaptive immune responses in ovarian cancer (Presenter: Chiara Berlato)
• Exercise training improves tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling and sensitizes breast cancer to immune checkpoint blockade
  (Presenter: Igor L. Gomes-Santos)

Cancer Today, the AACR’s award-winning magazine and website, showcased several Annual Meeting presentations of interest to cancer patients, survivors, and caregivers:

• Genetic Testing Gaps (May 21)
• Understanding How Radiation Causes Cancer (April 27)
• Making Connections at the AACR Annual Meeting 2021 (April 16)
• The Week in Cancer News (April 16)
• Building COVID-19 Vaccine Confidence (April 15)
• Chemobrain: It’s Not Your Imagination (April 14)