Program
- Plenary Sessions
- Major Symposia
- Advances in Diagnostics and Therapeutics
- Advances in Organ Site Research
- Advances in Population Sciences
- Advances in Prevention Research
- Advances in the Science of Cancer Health Disparities
- Awards and Lectures
- Forums
- Special Sessions
- Educational Sessions
- Methods Workshops
- Meet-The-Experts
Live Streaming. All sessions held in the convention center (including the complete scientific program) were live-streamed to the virtual meeting platform. (Career development sessions, town meetings, and other events held in the meeting hotels were not streamed.) Session recordings are available to registered attendees through Wednesday, July 13.
Plenary Sessions
Saturday, April 9, 2022
Precancer Discovery Science
Chair: Catriona H.M. Jamieson, UCSD Moores Cancer Center, La Jolla, CA
- Avrum E. Spira, Johnson & Johnson and Boston University Medical Center, Boston, MA
- Rebecca Fitzgerald, Hutchison/MRC Research Center, Cambridge, United Kingdom
- Veronica Kinsler, The Francis Crick Institute, London, United Kingdom
- Susan M. Domchek, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
Sunday, April 10, 2022
Opening Plenary Session: Decoding Cancer Complexity, Integrating Science, Transforming
Patient Outcomes
Chair: Marcia R. Cruz-Correa, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR
- Michael R. Stratton, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
- Jason M. Crawford, Yale University, West Haven, CT
- Marcia C. Haigis, Harvard Medical School, Boston, MA
- Nickolas Papadopoulos, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
- Franziska Michor, Dana-Farber Cancer Institute, Boston, MA
- Charles L. Sawyers, Memorial Sloan Kettering Cancer Center, New York, NY
Monday, April 11, 2022
Decoding Cancer Health Disparities: Integration of Complex Data and Diversity to Achieve Equity
Chair: Mariana C. Stern, USC Norris Comprehensive Cancer Center, Los Angeles, CA
- Yu Shyr, Vanderbilt University Medical Center, Nashville, TN
- Matthew L. Meyerson, Dana-Farber Cancer Institute, Boston, MA
- Olusegun I. Alatise, Obafemi Awolowo University, Ile-Ife, Nigeria
- Andy Futreal, The University of Texas MD Anderson Cancer Center, Houston, TX
- Cheryl L. Willman, Mayo Clinic Comprehensive Cancer Center, Rochester, MN; and University of New Mexico Comprehensive Cancer Center, Albuquerque, NM
Tuesday, April 12, 2022
Precision Medicine for Immuno-Oncology and the Promise for the Future
Chair: Carl H. June, University of Pennsylvania, Philadelphia, PA
- Ton N. Schumacher, Netherlands Cancer Institute, Haarlem, The Netherlands
- Thomas F. Gajewski, University of Chicago, Chicago, IL
- Luis A. Diaz, Memorial Sloan Kettering Cancer Center, New York, NY
- Shannon J. Turley, Genentech, Inc., South San Francisco, CA
Wednesday, April 13, 2022
Tumor Evolution and Therapeutic Resistance
Chair: Anna D. Barker, Ellison Institute for Transformative Medicine, Los Angeles, CA
- Emmanuelle Passegué, Columbia University Irving Medical Center, New York, NY
- Peter J. Campbell, Wellcome Trust Sanger Institute, Cambridge, United Kingdom
- Christine A. Iacobuzio-Donahue, Memorial Sloan Kettering Cancer Center, New York, NY
- Nicholas E. Navin, The University of Texas MD Anderson Cancer Center, Houston, TX
- Charles Swanton, The Francis Crick Institute, London, United Kingdom
AACR Annual Meeting 2022 Highlights: Vision for the Future
Chair: Marcia R. Cruz-Correa, University of Puerto Rico Comprehensive Cancer Center, San Juan, PR
- Danny R. Welch, University of Kansas Cancer Center, Kansas City, KS
- Jennifer A. Doherty, University of Utah Huntsman Cancer Institute, Salt Lake City, UT
- Lillian L. Siu, UHN Princess Margaret Cancer Center, Toronto, ON, Canada
Major Symposia
- AACR-Bayard D. Clarkson Symposium on Cancer Stem Cell Metabolism, Proteostasis, and Metastasis
- Accelerated, Conditional, Provisional, or Temporary? A Comparison of International Expedited Approval Programs
- Adipose Tissue as a Driver of Carcinogenesis
- Aging and the Tumor Microenvironment’s Impact on Minimal Residual Disease and Cancer Recurrence
- Applications of Real-World Data: What Is the Role of Real-World data in Clinical Research and Practice?
- Artificial Intelligence in Cancer Research and Care
- Biomarkers of Cancer Evolution: From Bench to Clinical Application
- Bone Metastasis
- Cancer Drugs Repurposing for Rare Genetic Disorders: A Unique Opportunity for Patients
- Cancer Vaccines: New Developments and Clinical Response
- CAR T cells for Solid Tumors: Bullish or Bearish?
- Challenging Drug Targets
- Clinical Progress with CD3 Bispecifics
- Considerations and Concerns Among the Asian American and Pacific Islander (AAPI) Community
- Defining Clinical Benefit: Accelerated Approval in Precision Oncology
- Digital and Computational Histopathology: Taking Cancer Diagnostics to the Cutting Edge
- Dose Optimization for Antibody-Drug Conjugates
- Epigenetic Alterations as Cancer Therapeutic Targets
- Epigenome Biology and Cancer
- Extracellular Matrix Remodeling in Cancer
- Extrachromosomal DNA: Origins and Significance
- FDA OCE’s Educational Programs and Integration of Regulatory Science in Academia
- Genome Instability as a Driver of Cancer Evolution
- Germline Mutations as Drug Targets
- Highlighting the AACR/HBS/MMRF Summit: Reducing Disparities and Democratizing Cancer Care
- Identification of Pediatric Cancer Dependencies
- Immunoprevention and Clinical Trials
- KRAS Anniversary Session: Novel Mechanisms for Targeting KRAS
- Liquid Biopsy: From Discovery to Clinical Application
- Macroenvironmental and Microenvironmental Drivers of Cancer Stem Cell Generation
- Mechanisms of Cancer Stem Cell Immune Evasion
- Mechanisms of Structural Mutations in Cancer
- Metabolic and Nutritional Regulation of Cancer and Immunity
- Modern Synthetic Lethality Strategies in Targeting the DNA Damage Response and Beyond: Moving beyond PARP and BRCA
- Multiomics Approaches for Novel Oncopathogen Discovery and Related Mechanisms
- Myeloid Cell Control of Therapeutic Antitumor Immunity
- Nerves, Cancer, and Immunity
- Novel Genetic Screening Strategies to Identify Therapeutic Targets in Cancer
- Pediatric Oncology Drug Discovery and Development
- Physical Aspects of Cancer and Physical Sciences of Oncology
- Predictive Biomarkers for Precision Radiation Oncology
- Presidential Select Symposium: Aging, Stress, and Cancer
- Profiling Molecular Proximity in Cancer Research
- Radiation and Immunotherapy
- Role of the Metastatic Microenvironment
- Screening, Detecting, Intervening Earlier in Clinical Care of Underserved Populations
- Successful Development of Cancer Therapies for Ultra-Rare Indications
- Supporting Smoking Cessation Among Patients with Cancer Who Use Tobacco Products
- Targeted Protein Degradation: Exploring New Targets and E3 Ligases
- Tumor Dormancy
- Understanding Microbe-Tumor Interactions in Health and Disease: From Basic Mechanisms to Applied Microbial-Based Cancer Therapy
- Using Patient-Generated Data to Optimize the Dose for Oncology Drugs
Advances in Diagnostics and Therapeutics
- Adoptive Cellular Therapy: Treatment for the Masses
- Advances in Precision Diagnostics and Therapeutics
- Cancer Metabolic Phenotypes: A Precision Medicine Perspective for Radiation Oncology?
- Clinical to Genetic Monitoring for Hereditary Cancers
- Deep Learning for Cancer Imaging
- How Should Clonal Hematopoiesis Impact Cancer Treatment Decisions?
- Interpreting and Building Trust in Artificial Intelligence Models
- Machine Learning to Translate the Cancer Genome and Epigenome into Biological and Clinical Insights
- New Developments in Immunotherapy: Targeting and Localizing Cytokine Activity
- New Horizons in Neoadjuvant and Adjuvant Immunotherapy for Solid Tumors
- Next-Generation Costimulatory Receptor Agonists for Cancer Immunotherapy and Combination Therapy
- Peptide–Peptide Interaction Inhibitors in Cancer Therapeutics
- Targeting Transcription Factors
- Technologies to Understand Malignant Clonal Behavior at Single Cell Resolution
- Theranostics: The Interception of Detection and Treatment
Advances in Organ Site Research
- Advances in Bladder Cancer
- Advances in Glioblastoma Cancer Research and Cancer Care
- Advances in Neuroblastoma Research
- Advances in Ovarian Cancer Screening and Treatment
- Bone Marrow Immune Microenvironment
- Breast Cancer Genomics in Latin America
- Gastric Cancer: From Biology to Therapy
- Models for Rare Cancers
- Pediatric Tumors
- Progress in Understanding Nonalcoholic Fatty Liver Disease-Induced Liver Cancer and Associated Disparities
- The Next Generation of Targets for Prostate Cancer
- Triple Negative Breast Cancer: Molecular Insights and Treatment Advances
- Understanding Microbe-Tumor Relationships in Colorectal Cancer
Advances in Population Sciences
- Functional Role of Long Tail Coding and Non-coding Mutations in Cancer
- Impact of Off-Label Therapies in Cancer Care and Outcomes across Populations
- Where You Live Matters: From Biological to Social Determinants of Cancer Outcomes
Advances in Prevention Research
Advances in the Science of Cancer Health Disparities
- Applying an Equity Lens to Implementation Research: A Pathway to Reduce Cancer Health Disparities
- Molecular Epidemiology of Stress and Discrimination and Cancer Outcomes
- Obesity and Health Disparities in Cancer
Awards and Lectures
Forums
- Addressing Disparities in Cervical Cancer: A Tale of Two Strategies
- Advances in Lung Cancer
- Breaking Down Silos: If We Did It during the COVID Pandemic, Why Not for Cancer?
- How Have Genome-Wide Association Studies Impacted Cancer Research?
- Impact of Telehealth on Cancer Care Delivery
- Insights Into Choosing the Right Immune Oncology Drug Combinations for Patients
- Oligometastatic Disease
- Pancreas Cancer: Why Are We Moving So Slowly?
- Precision Oncology for Pediatric Cancer
- Untangling Mechanisms of Sensitivity and Resistance to Immune Checkpoint Blockade
- Vaccine Effectiveness in Cancer Patients with Immunotherapy
- What Is the Causal Link between Race and Early Onset of Colon Cancer?
Special Sessions
- AACR-ASCO Joint Session: Pathophysiology and New Treatments for Cancer-Associated Thrombosis
- AACR-JCA Joint Session on Organoids: Tumor Cells, Microenvironments, and Beyond
- Decoding Cancer Complexity and Transforming Patient Outcomes Using AACR Project GENIE
Educational Sessions
- Addressing Cancer Care Quality and Cancer Outcomes in Medicaid Populations
- Advances in Ligand Discovery Against Poorly Tractable Targets
- Advances in SHP2 Biology and Therapeutics for Targeting RAS-Driven Cancers
- Big Data Resources in Pediatric Cancer
- Cancer Dormancy and Immune Regulation
- Cancer Survivorship
- Cancer Target Validation Using Chemical Probes
- Chemistry to the Clinic, Part 1 of 3: Targeting Ras Beyond G12C
- Chemistry to the Clinic, Part 2 of 3: Progress in Small Molecule Cancer Immunology Therapy
- Combination Therapeutic Strategies in the Treatment of Lung Cancer
- Considerations of Tissue-Specific Aging in Cancer Research
- Defining Cancer Evolution Types and Their Impact on Cancer
- Degrading Undruggable Targets in Pediatric Cancer
- Developing Replicable Genomic Classifiers of Cancer
- Diet and Lifestyle Risks for Cancer
- Diet, Microbiota, and Cancer Immunotherapies
- Drug Resistance: Challenges and Prospects
- Examining Tissue Specific Stroma to Increase Therapeutic Opportunities in Metastasis
- Immunocytokines: Strategies for Drug Delivery and Tissue Targeting
- Implementation Science: Efforts to Improve Cancer Health Equity
- Increasing Diverse Participation in Biomedical Cancer Research: Best Practices and Innovation
- Introduction to AI/ML in Cancer Genomics and Imaging
- Metabolism, Inflammation, and Immunotherapy
- Minimal Residual Disease in Solid Tumors: What Does It Mean and How Should It Guide Treatment Decision-Making?
- Natural Killer (NK) Cells: From Cancer Orchestrators to Car-NK Therapy
- Neoadjuvant Immunotherapy: The Next Steps Towards Perfectionism and Personalization
- Novel Antibody Drug Conjugates
- Novel Strategies to Target the Cyclin-Dependent Kinases
- Organoids in Cancer Research
- Outreach and Education in COVID-19 Times: Opportunities and Lessons Learned
- Pathology for Cancer Researchers
- Polygenic Risk Scores: Considerations for Development and Evaluation
- Precision Cancer Prevention
- Predictive Biomarkers for Immunotherapy
- Radiotheranostics for Cancer
- Regenerative Response of Irradiated Tissues: Models and Signaling Pathways
- Roles of RNA in Cancer and Cancer Therapies
- Sex Matters: Understanding the Effect of Sex on Shaping the Tumor and Response to Cancer Therapy
- Single Cell Biology in Scale and Spatial Genomics
- Systems Biology Approaches to Cancer
- The Epigenetics of Cancer
- The Evolving Crosstalk in the Cancer Stem Cell Niche
- The Importance of Surgeon Engagement for Translational Cancer Research
- The Science Behind Cytokine Release Syndrome
- Tumor Immunology and Immunotherapy for Nonimmunologists: The Immunological Basis of Durable Responses to Cancer Immunotherapy
- Understanding Cell Death in Cancer Therapy
- Unfolding the Unfolded Protein Response (UPR) as a Diagnostic and Therapeutic Target in Cancer
Methods workshops
- Artificial Intelligence in Cancer Imaging
- Biobanks: Why You Need Them in Your Cancer Research Program
- Design and Analysis of Real-World Data for Cancer Research
- Engineering a new generation of nanomedicines
- From Molecular Glues to Interfacial Binders: Targeting Protein Complexes with Small Molecule Inhibitors
- Introduction to Network Biology and Knowledge Graphs in Cancer Research
- Liquid Biopsy: from biology to clinical use
- Methods and Implications for Using Race and Ancestry in Cancer Research
- Mitochondrial Dynamics
- New Concepts in Unraveling the 3D Genome
- Spatial Analysis on the Tumor Microenvironment
- Spatial Transcriptomics and Cellular Imaging analysis of the tumor microenvironment
- Using Real-world Clinico-genomic Data: AACR Project GENIE As A Use Case
Meet-the-expert
- #ResearchMatters: Tales from a Translational Physician Scientist Tackling Thoracic Tumors
- A Multilevel Outreach Framework to Increase Representation of African Americans and Latinx Populations in Genomic Research
- Advances in Science and Treatment of Myeloproliferative Neoplasms
- Base Excision Repair and Cancer
- Cancer Metabolism: Diet and Therapeutics
- Circulating Tumor DNA: Concepts, Challenges, and Future Opportunities
- Decoding Kidney Cancer
- Endometrial Cancer: Obesity and Disparities
- Epigenomics in Cancer Therapeutics
- Epithelial Stem Cells: How Memories of Stressful Experiences Fuel Cancer
- Evolutionary Therapy
- Exploring Latino Cancer Health Disparities with a Focus on Prevention and Community Intervention
- Glycans Tell Us About Function and Status: Applying this Information to the Detection and Treatment of Cancer
- History of Infections and Targets of Successful Immune Defense Inform Designs of Preventive Cancer Vaccines
- Human Natural Killer Cells: Basic Biology and Novel Clinical Applications for Cancer
- Immunogenomics of High-Grade CNS Malignancies
- Improving Treatment of Primary and Metastatic Brain Tumors: Emerging Strategies
- Integrating Evolutionary Dynamics into Treatment for Metastatic Cancer
- Lessons Learned Leading a Comprehensive Translational Program in Pancreatic Cancer: Precision Medicine One Patient at a Time
- Luminal B breast cancer genomics in Hispanic/Latinas: a window to tumor size and immune infiltration
- Mechanisms of Malignant Transformation of the Immune System and Precision Immunotherapy
- Next Generation Pathology: From Histopathology to Artificial Intelligence
- NGS Profiling
- Obesity, Diabetes, and Breast Cancer
- Patient-Derived Organoids: From Drug Development to Precision Oncology
- Predicting Outcomes in Neuroendocrine Tumors
- Proteogenomics as a driver for discovery of novel mechanisms and therapeutic targets in lymphoma
- Recent Developments in the Treatment of Soft Tissue Sarcomas and GIST: Biology Driven Drug Development
- Scalable Integrative Analysis of Large-Scale Biobanks, Whole Genome Sequencing Studies and Functional Multi-Omic Data
- Seeing Is Believing: Effective Data Visualization
- Targeting Clonal Heterogeneity in Treatment-refractory Brain Cancers with Rationally Designed Immunotherapies: Advances and Challenges
- The Current Status of Precision Medicine Trials in Cancer: Towards a Future Precision Medicine Strategy
- The Genomics of HPV Integration in Cancers
- The KEAP1-NRF2 System in Cancer Biology and Medicine
- The Melanoma Revolution and Lessons Learned From Basic Biology of Skin
- The Role of a Commonly Used Medication in the Prevention of Ovarian and Endometrial Cancers: A Spotlight on Statins
- Understanding and Targeting Aberrant RNA Splicing in Cancer
- Update on agonist CD40 antibodies for cancer immunotherapy