Denise Chan, PhD, principal investigator and assistant professor in the Department of Radiation Oncology at the University of California, San Francisco (UCSF), died October 24, 2014. Chan was a member of the AACR since 2010.
Born in Los Angeles, April 4, 1977, Chan received her doctorate from Stanford University in Stanford, California, after completing her bachelor’s degree from the University of California, Los Angeles,in 1999.
Chan’s doctoral research focused on the role of prolylhydroxylation in the coordinated regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor.
In 2004, she received the Malcolm A. Bagshaw Award by Stanford University School of Medicine in recognition of her novel approach to understanding the structural basis of oxygen sensing in mammalian cells.
She was also awarded an individual Ruth L. Kirschstein National Service Postdoctoral Fellowship from the National Cancer Institute for 2004 through 2009. During this time, she published 17 papers, including a seminal piece of work about the recruitment of tumor vasculature to solid tumors.
In 2009, Chan joined UCSF, and worked on several projects during her time there, including research into the effects of hypoxia on estrogen receptors in breast cancer and synthetic lethality screening for new therapeutics.